A5103138177- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Neutropenia and Cancer Infections
- DNA Repair Mechanisms
- Heart Failure Treatment and Management
- Phosphodiesterase function and regulation
- Genetic Syndromes and Imprinting
- PI3K/AKT/mTOR signaling in cancer
- Genetics and Neurodevelopmental Disorders
- Blood disorders and treatments
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Renin-Angiotensin System Studies
- Pain Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- Kruppel-like factors research
- Bacterial Identification and Susceptibility Testing
- Lung Cancer Treatments and Mutations
- Endometriosis Research and Treatment
Huaian First People’s Hospital
2014-2025
Nanjing Medical University
2011-2025
First Hospital of Jiaxing
2021-2022
Jiaxing University
2021-2022
The PI3K/PTEN/AKT/mTOR signaling pathway has been implicated in resistance to cisplatin. In the current study, we determined whether common genetic variations this are associated with platinum-based chemotherapy response and clinical outcome advanced non-small cell lung cancer (NSCLC) patients.Seven single nucleotide polymorphisms (SNPs) core genes of were genotyped 199 patients analyzed for associations response, progression-free survival (PFS) overall (OS).Logistic regression analysis...
Kruppel-like factor 2 (KLF2) expression is diminished in many malignancies. However, its and role nonsmall-cell lung cancer (NSCLC) remain unknown. In this study, we found that KLF2 levels were decreased NSCLC tissues compared with adjacent normal tissues. Its level was significantly correlated TNM stages, tumor size, lymph node metastasis. Moreover, patients low of had a relatively poor prognosis. Furthermore, knockdown by siRNA could promote cell proliferation, while ectopic inhibited...
NBS1 plays important roles in maintaining genomic stability as a key DNA repair protein the homologous recombination pathway and signal modifier intra-S phase checkpoint. We hypothesized that polymorphisms of are associated with hepatic cancer (HCC) risk. The rs1805794 C/G polymorphism has been frequently studied some cancers discordant results, but its association HCC not investigated. Moreover, studies 3'UTR variant rs2735383 have touched upon HCC. This study examined contribution these...
Esophageal cancer (ESCC) is one of the most common causes cancer-associated mortality in China. The present investigation reveals that non-coding RNAs (ncRNAs), including long ncRNAs (lncRNAs), exert a significant effect on initiation, development and metastasis malignant tumors, ESCC. However, to best our knowledge, function non-protein-coding genes host small nucleolar has not been investigated cancer, particularly expression gene 6 (SNHG6) 70 ESCC tissues paired adjacent was measured by...
Objective . To investigate the protective effect of miR‐542‐3p on cardiomyocyte injury and related mechanisms. Methods A hypoxia/reoxygenation model was established. The expression levels PDE4D were detected using qRT‐PCR; luciferase reporter assay system used to detect targeting relationship between PDE4D; overexpressing transfected into cardiomyocytes, ROS release by immunofluorescence while cellular apoptosis TUNEL; western blot applied PDE4D, phosphorylated protein kinase (p‐PKA), cyclic...