A5078515712- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Protist diversity and phylogeny
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Photosynthetic Processes and Mechanisms
- Mesenchymal stem cell research
National Heart Lung and Blood Institute
2018-2023
National Institutes of Health
2018-2023
Article26 July 2021Open Access Source DataTransparent process Host autophagy mediates organ wasting and nutrient mobilization for tumor growth Rojyar Khezri Centre Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty University Oslo, Norway Department Molecular Biology, Research, Oslo Hospital, Search more papers by this author Petter Holland Todd Andrew Schoborg Biology Physiology Center, National Heart, Lung Blood Institute, Institutes Health, Bethesda, MD, USA Ifat...
Cell division is critical for development, organ growth, and tissue repair. The later stages of cell include the formation microtubule (MT)-rich central spindle in anaphase, which required to properly define equator, guide assembly acto-myosin contractile ring ultimately ensure complete separation isolation two daughter cells via abscission. Much known about molecular machinery that forms spindle, including proteins needed generate antiparallel overlapping interzonal MTs. One protein has...
Abstract Cell division is critical for development, organ growth, and tissue repair. The later stages of cell include the formation microtubule (MT)-rich central spindle in anaphase, which required to properly define equator, guide assembly acto-myosin contractile ring, ultimately ensure complete separation isolation two daughter cells via abscission. Much known about molecular machinery that forms spindle, including proteins needed generate antiparallel overlapping interzonal MTs. One...
During tumor growth - when nutrient and anabolic demands are high – autophagy supports metabolism through lysosomal organelle turnover recycling 1 . Ras-driven tumors additionally invoke non-autonomous in the microenvironment to support growth, part transfer of amino acids 2–4 Here we uncover a third critical role mediating systemic organ wasting mobilization for using well-characterized malignant model Drosophila melanogaster Micro-computed X-ray tomography metabolic profiling reveal that...
Abstract During tumor growth-when nutrient and anabolic demands are high-autophagy supports metabolism growth through lysosomal organelle turnover recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support growth, part transfer of amino acids. Here we uncover a third critical role mediating systemic organ wasting mobilization for using well-characterized malignant model Drosophila melanogaster. Micro-computed X-ray tomography metabolic...