A5068220718- Evolution and Genetic Dynamics
- Evolutionary Game Theory and Cooperation
- Bacterial biofilms and quorum sensing
- Bacterial Genetics and Biotechnology
- Insect symbiosis and bacterial influences
- Vibrio bacteria research studies
- Microbial Community Ecology and Physiology
- Mathematical and Theoretical Epidemiology and Ecology Models
- Biochemical and Molecular Research
- Gene Regulatory Network Analysis
- Adenosine and Purinergic Signaling
- Biochemical Acid Research Studies
- Antimicrobial Peptides and Activities
- Pharmacological Effects of Natural Compounds
- Enzyme function and inhibition
- Metabolism and Genetic Disorders
- Ecosystem dynamics and resilience
- Virus-based gene therapy research
- RNA modifications and cancer
- demographic modeling and climate adaptation
University of Zurich
2014-2019
Ludwig-Maximilians-Universität München
2016-2017
Georgia Institute of Technology
2016
University of Edinburgh
2014
Swiss Federal Institute of Aquatic Science and Technology
2014
Centre for Immunity, Infection and Evolution
2014
National Heart Lung and Blood Institute
1963
Background and objectives: Conventional antibiotics select strongly for resistance are consequently losing efficacy worldwide. Extracellular quenching of shared virulence factors could represent a more promising strategy because (i) it reduces the available routes to (as extracellular action precludes any mutations blocking drug's entry into cells or hastening its exit) (ii) weakens selection resistance, as fitness benefits emergent mutants diluted across all in cooperative collective. Here,...
Bacteria secrete a variety of compounds important for nutrient scavenging, competition mediation and infection establishment. While there is general consensus that secreted can be shared therefore have social consequences the bacterial collective, we know little about physical limits such interactions. Here, address this issue by studying sharing iron-scavenging siderophores between surface-attached microcolonies bacterium Pseudomonas aeruginosa Using single-cell fluorescence microscopy,...
Phenotypic plasticity in response to competition is a well‐described phenomenon higher organisms. Here, we show that also bacteria have the ability sense presence of competitors and mount fine‐tuned responses match prevailing levels competition. In our experiments, studied interspecific for iron between bacterium Pseudomonas aeruginosa (PA) its competitor Burkholderia cenocepacia (BC). We focused on PA phenotypically adjust production pyoverdine, an iron‐scavenging siderophore. found...
We probed the evolutionary robustness of two antivirulence drugs, gallium and flucytosine, targeting iron-scavenging pyoverdine in opportunistic pathogen Pseudomonas aeruginosa. Using an experimental evolution approach human serum, we showed that treatments are not evolutionarily robust per se, but vary their propensity to select for resistance.Treatments inhibit expression or functioning bacterial virulence factors hold great promise be both effective exert weaker selection resistance than...
How unicellular organisms optimize the production of compounds is a fundamental biological question. While it typically thought that optimized at individual‐cell level, secreted could also allow for optimization group leading to division labor where subset cells produces and shares compound with everyone. Using mathematical modeling, we show evolution such depends on cost function production. Specifically, any trait saturating benefits, linear costs promote uniform levels across cells....
Given the rise of bacterial resistance against antibiotics, we urgently need alternative strategies to fight infections. Some propose should disarm rather than kill bacteria, through targeted disruption their virulence factors. It is assumed that this approach (i) induces weak selection for because it only minimally impact fitness, and (ii) specific, interfering with factor in question. pathogenicity emerges from complex interactions between pathogens, hosts environment, such assumptions may...
Abstract Bacteria secrete a variety of compounds important for nutrient scavenging, competition mediation and infection establishment. While there is general consensus that secreted can be shared therefore have social consequences the bacterial collective, we know little about physical limits such interactions. Here, address this issue by studying sharing iron-scavenging siderophores between surface-attached microcolonies bacterium Pseudomonas aeruginosa . Using single-cell fluorescent...
Abstract How unicellular organisms optimize the production of compounds is a fundamental biological question. While it typically thought that optimized at individual-cell level, secreted could also allow for optimization group leading to division labor where subset cells produces and shares compound with everyone. Using mathematical modelling, we show evolution such depends on cost function production. Specifically, any trait saturating benefits, linear costs promote uniform levels across...
Abstract Given the rise of bacterial resistance against antibiotics, we urgently need alternative strategies to fight infections. Some propose should disarm rather than kill bacteria, through targeted disruption their virulence factors. It is assumed that this approach (i) induces weak selection for because it only minimally impact fitness, and (ii) specific, interfering with factor in question. pathogenicity emerges from complex interactions between pathogens, hosts, environment, such...
Abstract Background and objectives Treatments that inhibit the expression or functioning of bacterial virulence factors hold great promise to be both effective exert weaker selection for resistance than conventional antibiotics. However, evolutionary robustness argument, based on idea anti-virulence treatments disarm rather kill pathogens, is controversial. Here we probe two repurposed drugs, gallium flucytosine, targeting iron-scavenging pyoverdine opportunistic human pathogen Pseudomonas...