A5103116568- Ion channel regulation and function
- Electrochemical Analysis and Applications
- Cardiac electrophysiology and arrhythmias
- Mass Spectrometry Techniques and Applications
- Spectroscopy and Quantum Chemical Studies
- Neuroscience and Neuropharmacology Research
- Advancements in Photolithography Techniques
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Sensors
- Molecular Junctions and Nanostructures
- Photoreceptor and optogenetics research
- Beetle Biology and Toxicology Studies
- Integrated Circuits and Semiconductor Failure Analysis
- Chemical Synthesis and Analysis
- Advanced Synthetic Organic Chemistry
- Electron and X-Ray Spectroscopy Techniques
- Fuel Cells and Related Materials
- Rocket and propulsion systems research
- Industrial Vision Systems and Defect Detection
- Phytochemical compounds biological activities
- Advanced Chemical Physics Studies
- Neuroscience and Neural Engineering
- Nanopore and Nanochannel Transport Studies
- Advanced Chemical Sensor Technologies
- Protein Structure and Dynamics
City College of New York
2015-2024
Photronics (United States)
2016-2024
City University of New York
1978-2024
Irvine University
2021
University of California, Irvine
2021
University of Toledo
2017-2018
Palo Alto Institute
2018
Michael & Associates
2017
Pfizer (United States)
2010-2012
University of Pittsburgh
2005-2011
Replacement of the central, para-substituted fluorophenyl ring in γ-secretase inhibitor 1 (BMS-708,163) withthe bicyclo[1.1.1]pentane motif led to discovery compound 3, an equipotent enzyme with significant improvements passive permeability and aqueous solubility. The modified biopharmaceutical properties 3 translated into excellent oral absorption characteristics (∼4-fold ↑ Cmax AUC values relative 1) a mouse model inhibition. In addition, SAR studies other replacements indicate intrinsic...
The potent cytotoxins pederin and psymberin have been prepared through concise synthetic routes (10 14 steps in the longest linear sequences, respectively) that proceed via a late-stage multicomponent approach to construct N-acyl aminal linkages. This route allowed for facile preparation of number analogs were designed explore importance alkoxy group functional groups two major subunits on biological activity. These analogs, including pederin/psymberin chimera, analyzed their growth...
"Oxidized" amides, as represented by acyl aminals and hemiaminals, are integral subunits of several natural products that exhibit useful biological activity. In this paper a multicomponent approach to these groups from acylimine intermediates is demonstrated. The acylimines accessed through sequence nitrile hydrozirconation acylation, making highly versatile amide synthesis for range applications in target- diversity-oriented synthesis.
The transformation is complete! total synthesis of theopederin D (see structure), a potent cytotoxin, has been achieved through oxidative cleavage carbon–carbon bond. Other key transformations include an acid-mediated functionalization tetrahydrofuranol, syn-selective glycal epoxide ring-opening, and asymmetric aldehyde/acid chloride condensation. Supporting information for this article available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z802548_s.pdf or from author....
Water molecules in clefts and small clusters are a significantly different environment than those bulk water. We have carried out ab initio calculations that demonstrate this series of clusters, showing cooperative effects must be taken into account the treatment hydrogen bonds water such bounded systems. Hydrogen between simulations treated most frequently by using point-charge potentials, as TIP3P or SPC, sometimes with polarizable extension. These produce excellent results water, for...
α-Branched amides are prepared by multicomponent reactions in which nitriles undergo hydrozirconation to form metalloimines that react with acyl chlorides. The resulting acylimines a variety of π-nucleophiles the presence Lewis acids desired amides.
A ten-step program: The potent cytotoxin pederin and several analogues have been prepared through an efficient route that proceeds in ten steps (longest linear sequence) from isobutyraldehyde. key transformation is a multicomponent N-acylaminal construction (see scheme) allows for late-stage fragment coupling diversification.
Psymberin is a sponge-derived natural product that shows striking selectivity as cytotoxic agent. Conformational mobility has precluded stereochemical assignment for the acyl fragment of this molecule (psymberic acid) by NMR. Herein we report stereoselective syntheses all four stereoisomers psymberic acid. A comparison acid-mediated cyclization products these compounds to psymberin's acidic methanolysis showed configuration be 4S,5S.
Hybrid Aircraft Propulsion System Synthesis (HAPSS) is a computer program that designs, sizes, and analyzes generic hybrid electric propulsion systems for aircraft. The development of this began with the creation fan design tool during NASA SBIR contract titled “The Design Integration Distributed Fan within Split-Wing”. Since completion in July 2010, has expanded to combine many aspects system. This paper addresses sizing performance analysis turboelectric distributed system dual-use...
Ion channels are ubiquitous throughout all forms of life. Potassium even found in viruses. Every cell must communicate with its surroundings, so cells have them, and excitable cells, particular, especially nerve depend on the behavior these channels. channel be open at appropriate time, only then, that each opens response to stimulus tells open. One set channels, including those responds voltage. There is a standard model for gating has section protein moving However, there evidence protons...
A study has been made of the attack amines on platinum complexes containing ethene derivatives. When 2-ammonioethanide compounds (H3NCHRCHR′–Pt) are formed, direction is determined by electronic rather than steric effects unless latter very large. Reactions not complete, and equilibrium constants show that factors tend to prevent formation compounds. The production azaplatinacyclobutane ring enhanced factors. Five-co-ordinate species formed in some cases. Hydrogen-1 n.m.r. data reported.
Turboelectric Distributed Propulsion (TeDP) describes a power train consisting of turboshaft engine which is used solely to provide electrical through generator electric motors driving propulsive fans are distributed above, below, or inside wing. Recent advancements in electronics, computers, and distribution have made propulsion feasible the purpose studies described here has been integrate this new type with real airframes designed specific civilian military missions. Empirical Systems...
Ion channels in cell membranes control entry and exit of ions; their gating (opening closing) is key to functioning. It known that protons can pass through the voltage-sensing domain (VSD) such as Kv1.2. Quantum calculations for a section VSD show steps take responding voltage no major displacement protein backbone with change; 70 amino acids are included, 42 side chains (9 directly proton path), 28 only, 24 water molecules. Protons provide much current, capacitative current immediately...
There are reasons to consider quantum calculations be necessary for ion channels, two types of reasons. The must account charge transfer, and the possible switching hydrogen bonds, which very difficult with classical force fields. Without understanding transfer bonding in detail, channel cannot understood. Thus, although approximations correct fields possible, they unable reproduce at least some details behavior a system that has atomic scale. However, there is second class effects...
The behavior of water in a pore nanometer dimensions is studied by Monte Carlo simulation over series densities, and with five different electric charge configurations, providing external fields from zero to extremely high values, exceeding 3 × 109 V m-1. contained tapered section that had an opening radius 0.25 nm into secondary below. wall was medium dielectric constant 4 (comparable the value protein), charges were placed wall. A reservoir, which remainder volume could exchange molecules,...
Abstract— The photoreduction of methylene blue in acid solution has been studied electrochemically. It found that proceeds red light, with only water available as reducing agent. Reaction energy considerations require two photons to reduce each molecule. A two‐photon mechanism involving a long‐lived dimer intermediate is proposed, and shown lead the observed kinetics, including dependence rate on light intensity concentration.
Auftrag ausgeführt! Die Totalsynthese des potenten Cytotoxins Theopederin D (siehe Struktur) beruht auf der oxidativen Spaltung einer Kohlenstoff-Kohlenstoff-Bindung. Als weitere wichtige Schritte sind die säurevermittelte Funktionalisierung eines Tetrahydrofuranols, eine syn-selektive Glycalepoxid-Ringöffnung und asymmetrische Kondensation Aldehyds mit einem Säurechlorid zu nennen. Supporting information for this article is available on the WWW under...
The transfer of a proton between two potential wells, as in hydrogen bond, has been extensively studied. However, under the influence an electric field studied to only very limited extent. We have used system methylamine−proton−methylamine help understand this type transfer. It is fairly realistic model systems that are importance (e.g., amino acids) and small enough calculate. energy surface for determined by ab initio calculation, using Gaussian 94, wave function then found...