A5064401604- Pain Management and Opioid Use
- Nutrition and Health in Aging
- Palliative Care and End-of-Life Issues
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Multiple and Secondary Primary Cancers
- Cancer-related cognitive impairment studies
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Erythropoietin and Anemia Treatment
- Cancer Treatment and Pharmacology
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Cancer survivorship and care
- Patient Dignity and Privacy
- Advances in Oncology and Radiotherapy
- Childhood Cancer Survivors' Quality of Life
- Cancer Research and Treatments
- Cancer Risks and Factors
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
University of Rijeka
2016-2025
Klinički Bolnički Centar Rijeka
2012-2023
University Hospital Centre Zagreb
2009-2023
Opća Bolnica Varaždin
2023
Weatherford College
2021
State Clinical Hospital "Clinical Oncology Center No. 1
2018
The aim of study was to investigate the expression proliferation factor Ki-67 and its relationship with histological grade, cancer stage, treatment outcome in squamous cell carcinoma larynx. Samples from 78 patients laryngeal were analysed retrospectively. Paraffin sections tumors immunohistochemically stained for expression. divided two groups according proliferative values (a low index group - Ki-67≤34 high group-Ki-67 >34). Statistical analysis data shows significant correlation among...
Athletes and bodybuilders often misuse androgenic/anabolic steroids. When used in therapeutic doses, these drugs produce clinical jaundice just a small number of recipients. We present 26-year-old male bodybuilder who self-administered high doses steroids that induced liver damage. One month before admission to the hospital, he testosterone enanthate (500 mg intramuscularly, twice weekly), stanozolol (40 mg/d), methylandrostenediol (30 mg/d by mouth, for 5 weeks). On admission, his bilirubin...
Early intervention with nutritional supplementation has been shown to halt malnutrition and may improve outcome in some patients colorectal cancer. The aim of this study was investigate whether dietary counseling, oral nutrition megestrol acetate during chemotherapy affected status survival advanced disease.Six hundred twenty-eight disease were included the from January 2000 through December 2009 divided into one two groups. Group I consisted 315 who monitored prospectively given support. II...
Multiple myeloma is a common haematological malignancy and immune dysfunction the hallmark of disease. It leads to an increased infection risk, which still major cause mortality. The spectrum characteristics have evolved with introduction novel agents. An understanding risk factors that increase susceptibility infections critical in fighting them. This retrospective investigation aimed establish incidence main non-transplanted hospitalised patients our department over 3-year period, as well...
ABSTRACT As immunotherapy is becoming more inevitable in everyday oncology, we are witnessing a higher number of patients who on immunosuppressive medication but also candidates for immune checkpoint inhibitors (ICIs) treatment. There have been few case reports and several small retrospective studies investigating the use ICIs liver transplant recipients mainly with hepatocellular carcinoma skin cancer, there no report regarding atezolizumab treatment metastatic breast cancer recipients. We...
Abstract Background Prognostic and predictive significance of epidermal growth factor receptor (EGFR) in colorectal carcinomas (CRCs) is still controversial. The aim the present study was to explore correlate membrane nuclear EGFR cyclin-D1 protein expression with gene status tumor cells. Methods Immunohistochemical FISH analysis performed on 135 archival formalin fixed paraffin embedded CRCs. Results Strong strong staining detected 16% 57% cases, respectively, samples. Gene amplification...
Immunotherapy has improved the prognosis of metastatic melanoma patients, although most patients do not achieve a complete response. While specific gut microbiome and dietary habits might influence treatment success, there is lack concordance between studies, potentially due to dichotomizing only into responders non-responders. The aim this study was elucidate whether with sustained response immunotherapy exhibit differences in composition among themselves, those were associated habits....
Background: There are limited real-world data (RWD) regarding the use of cyclin-dependent kinase (CDK) 4/6 inhibitors in western Balkan. The aim our study was thus to analyze factors influencing progression-free survival (PFS) and overall (OS), along with differences adverse effects CDK therapy a tertiary healthcare center Croatia. Methods: We evaluated medical demographic for 163 consecutive patients metastatic breast cancer treated CDK4/6 at least one month, from October 2018, after drug...
Gastric cancer (GC) is the eighth most common cause of deaths in Croatia and one causes worldwide. A reliable diagnostic tool for early detection GC essential.We previously suggested a pepsinogen test method to reduce mortality from by allowing detection. Here, we report an updated analysis prospective single-center clinical study evaluate sensitivity specificity determine whether this can be used as part routine laboratory assessment high-risk patients.We present mature data Croatian...
Quality of life is the cornerstone palliative care, and assessing it requires validated standardized questionnaires. However, majority questionnaires are not tested in a hospice setting. The purpose this study to evaluate quality using European Organization for Research Treatment Cancer Life Questionnaire Core 15 Palliative Care (PAL) (EORTC QLQ-C15-PAL) questionnaire validating Croatian language.The was conducted prospectively on 151 consecutive patients who were evaluated at admittance...
Objective. To examine differences in number and size of signal hyperintensities (SH) on magnetic resonance imaging (MRI) between patients with primary Sjögren syndrome (pSS) controls who all had frequent episodic tension-type headache (FETH), to investigate their relation platelet serotonin level (PSL), patient age, disease duration, activity. Methods. SH 22 pSS FETH were compared 20 aged-matched FETH, using the modified semiquantitative rating scale. Spectrofluorimetry was used for...
Background: The development of immunotherapy checkpoint inhibitors (ICIs) has revolutionized cancer care. However, old patients are underrepresented in most clinical trials, although they represent a significant proportion real-world patients. We aimed to evaluate the effectiveness and safety ICIs older than age 70. Methods: performed retrospective chart review 145 aged 70 or treated with for metastatic unresectable cancer. Results: Median progression-free survival (PFS) was 10.4 months (95%...
Gemcitabine in patients with nonresectable cancer of the biliary system or advanced gallbladder
Improvement in survival and clinical benefit response for patients with metastatic pancreatic cancer
Since smoking accounts for around 30% of all cancer deaths, public health campaigns often focus on cessation as a means primary prevention. However, after diagnosis is also associated with higher symptom burden and lower survival rate. As data regarding vary dramatically between different populations, we aimed to analyze prevalence in patients, diagnosis, the factors setting developing country. We performed cross-sectional survey 695 patients two clinical hospital centers. After 15.6%...