A5025867232- Vitamin D Research Studies
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Calcium signaling and nucleotide metabolism
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Asthma and respiratory diseases
- Lipid Membrane Structure and Behavior
- Multiple Myeloma Research and Treatments
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
Asthma UK
2012-2018
King's College London
2012-2018
Guy's Hospital
2013-2018
Medical Research Council
2013
ENT and Allergy
2001
Background Particulate matter (PM) pollutant exposure, which induces oxidative stress and inflammation, vitamin D insufficiency, compromises immune regulation, are detrimental in asthma. Objectives Mechanistic cell culture experiments were undertaken to ascertain whether abrogates PM-induced inflammatory responses of human bronchial epithelial cells (HBECs) through enhancement antioxidant pathways. Methods Transcriptome analysis, PCR ELISA delineate markers inflammation stress; with...
Urban particulate matter (UPM) exacerbates asthmatic lung inflammation and depresses immunity. Lung dendritic cells (DCs) react to airway particulates, have a critical role in linking innate adaptive immunity, but the direct effects of UPM on DCs, that been activated by granulocyte/macrophage colony-stimulating factor (GM-CSF), product stimulated normal human bronchial epithelial cells, has not investigated. Human blood CD1c(+) DCs were purified with presence or absence GM-CSF without LPS,...
Abstract Background Murine models suggest a critical functional role for the anti‐inflammatory cytokine IL ‐10 in local regulation of allergic airways inflammation. There is little corresponding information on human airway cells. This study aimed to investigate whether production regulates responses by respiratory mucosal leucocytes isolated from nasal polyps. Materials and Methods Nasal polyp tissue was harvested 24 patients sensitised aeroallergens with chronic rhinitis polyposis...
Abstract Background Particulate matter (PM) pollutant exposure, which induces oxidative stress and inflammation, vitamin D insufficiency, compromises immune regulation, are detrimental in asthma. Objectives Mechanistic cell culture experiments were undertaken to ascertain whether abrogates PM-induced inflammatory responses of human bronchial epithelial cells (HBECs) through enhancement antioxidant pathways. Methods Transcriptome analysis, PCR ELISA delineate markers inflammation stress; with...
Abstract Targeting CD38 in multiple myeloma has resulted outstanding responses. is widely expressed on cells and other hematological malignancies. Not much known about its expression solid tumors role the immune system. We have analysed a range of for distribution. To optimally target CD38, we generated novel antibody that depleting CD38-high expressing cells, but also modulatory properties. dissect exploited mRNA libraries, performed histochemistry (IHC) tumor sections, flow cytometry...