A5018077462- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- Acute Ischemic Stroke Management
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- ECG Monitoring and Analysis
- Wireless Body Area Networks
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Aortic Disease and Treatment Approaches
- Radiomics and Machine Learning in Medical Imaging
- Heart Failure Treatment and Management
- Neuroscience and Neural Engineering
- Hepatitis C virus research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Viral Infections and Immunology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Systems and Public Health
University of Liverpool
2024-2025
Azienda Ospedaliero-Universitaria di Modena
2022-2025
University of Modena and Reggio Emilia
2022-2025
Liverpool Heart and Chest Hospital
2024-2025
Liverpool John Moores University
2024-2025
Atrial fibrillation (AF) may be asymptomatic and the extensive monitoring capabilities of cardiac implantable electronic devices (CIEDs) revealed atrial tachi-arrhythmias short duration (minutes-hours) occurring in patients with no prior history AF without detection at a conventional surface ECG. Both terms "AHRE" (Atrial High-Rate Episodes) subclinical were used series studies, that evidenced association an increased risk stroke. Two randomized controlled studies planned order to assess...
Background. Atrial high rate episodes (AHRE) detected by cardiac implantable electronic devices (CIEDs) may be associated with a risk of progression towards long-lasting (≥24 h) and clinical atrial fibrillation (AF). Methods. Consecutive CIED patients presenting AHRE (with confirmation an arrhythmia lasting 5 min–23 h 59 min, ≥175/min, no AF at 12-lead ECG prior AF) were retrospectively enrolled. The aims this study to describe patients’ characteristics the incidence adverse events, second,...
The incidence of infections and death in patients implanted with cardiac implantable electronic devices (CIEDs) is not fully known yet.To describe the CIED-related infection death, their potential predictors a contemporary cohort CIED patients.All consecutive at our institution were prospectively enrolled. Follow-up visits performed 2 weeks after implantation for all patients, then every 6 months cardioverter defibrillator (ICD)/cardiac resynchronization therapy (CRT) 12 pacemaker (PM)...
Data on the impact of amyloidosis outcomes after transcatheter aortic valve implantation (TAVI) are limited. The objective this study was to evaluate 1-year risk adverse events post-TAVI in patients with amyloidosis. Patients undergoing TAVI (between 2005 and 2023) were categorized into 2 groups based presence primary outcome a composite endpoint: heart failure (HF), ischemic stroke, pacemaker implantation, acute kidney injury, all-cause death. Secondary assessed individual components...
Subclinical atrial fibrillation (AF) and high-rate episodes (AHREs) are often detected incidentally through cardiac implantable electronic devices or wearables, especially in asymptomatic patients. These pose a clinical challenge as they associated with an increased risk of stroke, albeit at lower rate compared AF. This review discusses the evolving understanding AHRE, highlighting uncertainties regarding optimal management, particularly use oral anticoagulants. Two key trials, ARTESiA...
Aims: The differentiation of left ventricular (LV) hypertrophic phenotypes is challenging in patients with normal ejection fraction (EF). myocardial contraction (MCF) a simple dimensionless index useful for specifically identifying cardiac amyloidosis (CA) and cardiomyopathy (HCM) when calculated by magnetic resonance. purpose this study was to evaluate the value MCF measured three-dimensional automated, machine-learning-based LV chamber metrics (dynamic heart model [DHM]) discrimination...
Abstract Background Atrial high rate episodes (AHRE) detected by cardiac implantable electronic devices (CIEDs) are associated with a higher risk of thromboembolic events, but whether oral anticoagulants (OACs) improve patient outcomes is still debated. On the other hand, OACs benefits in patients clinical atrial fibrillation (AF) well established. Therefore, potential progression AHRE towards AF should be promptly recognized. Purpose To evaluate incidence de-novo and its predictors. Methods...
Abstract Background Alarms generated by remote monitoring (RM) of cardiac implantable electronic devices (CIEDs) have been associated with worse clinical outcomes in patients heart failure (HF). However, whether the timing RM alerts impact on trajectories HF is still debated. Purpose To examine occurring first 180 days after CIED implant outcomes, as well potential predictors. Methods we retrospectively enrolled all a history implanted CRT-D or an ICD at our tertiary. We collected data...
<h3>Background</h3> Current evidence suggests that atrial high rate episodes (AHRE)/subclinical fibrillation are associated with increasing risk of clinical AF, and subsequently, ischaemic stroke other adverse cardiovascular events. <h3>Purpose</h3> To construct a high-performance model by machine learning (ML) for the prediction AHRE detected cardiac implantable electronic devices (CIEDs) capable sensing in European cohort. <h3>Methods</h3> We utilized data from prospective cohort patients...
Abstract Background Patients with heart failure undergoing CRT are an heterogenous and complex population. Selecting patients before implantation is essential to obtain a favorable response CRT-D. Data-driven cluster analysis may be approach identify different patients’ phenotypic categories. Purpose To clusters of CRT-D who share similar clinical phenotypes, evaluate the associations between outcomes, using analysis. Methods Three agglomerative hierarchical were performed in seen 2010 2019...
Abstract Background Patients with Atrial Fibrillation (AF) often exhibit Clinical Complexity (CC), defined as ≥2 features, i.e. patients aged ≥75 years plus a body mass index (BMI) &lt; 23/kg/m2 and/or bleeding history chronic kidney disease. No data are available about the clinical course of and CC who not taking oral anticoagulation (OAC). Purpose To assess risk thrombotic hemorrhagic events in OAC. Methods Retrospective study health care research network (TriNetX). Based on ICD-10-CM...
Abstract Background Atrial fibrillation (AF) is associated with cognitive impairment even in the absence of previous stroke. However, data on specific patterns and their association outcomes are limited. Purpose We aimed to identify different phenotypic groups AF patients stratified according domains using cluster analysis evaluate between identified clusters adverse outcomes. Methods used from a prospective observational study excluding those clinically overt performed hierarchical based...
Abstract Background In randomized clinical trials of Direct Oral Anticoagulants (DOACs), the assessment renal function impairment glomerular filtration rate (eGFR) in patients with Atrial Fibrillation (AF) has predominantly utilized Cockroft-Gault (CG) formula for estimating Creatinine clearance (CrCl). However, practice, several other formulas are employed. Limited data exist regarding evaluation and comparison eGFR/CrCl AF patients. Objectives This study aimed to assess concordance...
Abstract Background In patients with atrial fibrillation (AF), the prevalence, predictors and clinical implications of a potential discordance in estimating presence/absence chronic kidney disease (CKD) according to Cockroft-Gault (CG) CKD-EPI formulas remain unclear. Objective To examine characterized by evaluation renal function, specifically regard threshold for defining presence CKD an estimated glomerular filtration rate (eGFR) &lt; 60 ml/min, large cohort European AF patients,...