A5034832195- Blood disorders and treatments
- Acute Myeloid Leukemia Research
- Erythrocyte Function and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunodeficiency and Autoimmune Disorders
- interferon and immune responses
- Acute Lymphoblastic Leukemia research
- HIV/AIDS Research and Interventions
- RNA modifications and cancer
- Hemoglobinopathies and Related Disorders
- Virus-based gene therapy research
- HIV-related health complications and treatments
- Diabetes Management and Education
- Neuroblastoma Research and Treatments
- Cancer-related Molecular Pathways
Columbia University
2017
Montreal Clinical Research Institute
2011-2014
McGill University
2013-2014
Growth factor independence 1b (GFI1B) is a DNA binding repressor of transcription with vital functions in hematopoiesis. Gfi1b-null embryos die at midgestation very likely due to defects erythro- and megakaryopoiesis. To analyze the full functionality Gfi1b, we used conditionally deficient mice that harbor floxed Gfi1b alleles inducible (Mx-Cre, Cre-ERT) or erythroid specific (EpoR-Cre) Cre expressing transgenes. In contrast germline knockout, EpoR-Cre mediated ablation allows gestation, but...