A5039999379- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Attention Deficit Hyperactivity Disorder
- Neural dynamics and brain function
- Substance Abuse Treatment and Outcomes
- Cognitive Abilities and Testing
- Genetic Associations and Epidemiology
- Mental Health Research Topics
- Neurotransmitter Receptor Influence on Behavior
- Epilepsy research and treatment
- Prenatal Substance Exposure Effects
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Infant Health and Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Infant Development and Preterm Care
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Genomics and Rare Diseases
- Pediatric Pain Management Techniques
- Autism Spectrum Disorder Research
- Blind Source Separation Techniques
- Advanced Neuroimaging Techniques and Applications
National University of Ireland, Maynooth
2025
Twin Cities Orthopedics
2002-2024
University of Minnesota
2014-2024
Earth and Space Research
2023
University of Washington
2023
University of Minnesota System
2004-2022
Queensland Children’s Hospital
2017-2022
The University of Queensland
2021-2022
Queensland Health
2021
Land Stewardship Project
2021
Abstract Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping abilities to specific structures (for example, lesion studies) and functions 1–3 task functional MRI (fMRI)). Mental health research care have yet realize similar advances from MRI. A primary challenge been replicating associations between inter-individual differences in structure or function complex cognitive mental phenotypes (brain-wide association studies...
<h3>Background</h3> The children of parents who abuse alcohol typically show reduced amplitude the P3 event-related potential wave. We determined if this effect was present in a population-based sample older adolescent boys, whether it associated with paternal antisocial personality and drug use, appeared youth childhood externalizing substance use disorders. <h3>Methods</h3> A statewide 502 male youth, identified from Minnesota birth records as members twin pairs, had their measured, using...
Abstract Reduced P300 amplitude is reliably found in individuals with a personal or family history of alcohol problems. However, alcoholism part broader externalizing spectrum that includes other substance use and antisocial disorders. We hypothesized reduced an indicator the common factor underlies disorders within this spectrum. Community males ( N =969) were assessed at age 17 visual oddball task. Externalizing was defined as underlying symptoms dependence, drug nicotine conduct disorder,...
The association between maternal depression and offspring dysfunction is well documented; however, little attention has been paid to psychopathology in the partners of these depressed mothers or how paternal might influence relationship dysfunction. purpose this study was explore whether major and/or antisocial behavior tended occur more frequently among (compared nondepressed mothers) examine disorders related psychopathology.Participants were drawn from Minnesota Twin Family Study, a...
Abstract The Enrichment Study (ES) was designed to extend the Minnesota Twin Family (MTFS) by oversampling 11-year-old twins at especially high risk for substance use disorders virtue of having a childhood disruptive disorder. sample ascertained from birth records. To identify high-risk twins, we conducted telephone screening interviews parent-reported symptoms attention-deficit/hyperactivity disorder (ADHD) and conduct (CD) as well indications academic disengagement. Twins who exceeded...
To examine the genetic and environmental influences of parental alcoholism on offspring disinhibited behavior.We compared effect history in adoptive non-adoptive families. In families with a alcohol dependence, we examined exposure to symptoms during life-time adolescent. Setting Assessments occurred at University Minnesota from 1998 2004.Adolescents adopted infancy were ascertained systematically records three private adoption agencies; non-adopted adolescents birth records. Adolescents...
Although substance use disorders are heritable, their complexity has made identifying genes underlying development challenging. Endophenotypes, biologically informed quantitative measures that index genetic risk for a disorder, being recognized potential to assist the search disorder relevant genes. After outlining criteria an endophenotype includes developmental considerations, we review how brain P300 response serves as of abuse and related externalizing disorders. The is highly heritable...
While the P3 component during target detection and novelty processing has been widely studied, less is known about its underlying network dynamics. A recent cognitive model suggests that frontal-parietal frontal-temporal interregional connectivity are related to attention/action selection target-related memory updating P3, respectively, but empirical work testing this lacking. Other importance of theta- delta-band between medial frontal cortex distributed cortical regions attention, stimulus...
Abstract Oscillatory activity is crucial for information processing in the brain, and has a long history as biomarker psychopathology. Variation oscillatory highly heritable, but current understanding of specific genetic influences remains limited. We performed largest genome‐wide association study to date power during eyes‐closed resting electroencephalogram (EEG) across range frequencies (delta 1–3.75 Hz, theta 4–7.75 alpha 8–12.75 beta 13–30 Hz) 8,425 subjects. Additionally, we KGG...
Observational studies have linked cannabis use to an array of negative outcomes, including psychiatric symptoms, cognitive impairment, and educational occupational underachievement. These associations are particularly strong when occurs in adolescence. Nevertheless, causality remains unclear. The purpose the present study was thus examine between prospectively assessed adolescent young-adult outcomes (psychiatric, cognitive, socioeconomic) three longitudinal twins (
Developmental changes in structure and functioning are thought to make the adolescent brain particularly sensitive negative effects of alcohol. Although alcohol use disorders relatively rare adolescence, initiation use, including problematic becomes increasingly prevalent during this period. The present study examined associations between normative drinking (alcohol initiation, binge drinking, intoxication) morphometry a sample 96 monozygotic twins. A priori regions interest included 11...
Abstract Several EEG parameters are potential endophenotypes for different psychiatric disorders. The present study consists of a comprehensive behavioral‐ and molecular‐genetic analysis such in large community sample ( N = 4,026) adolescent twins their parents, genotyped 527,829 single nucleotide polymorphisms SNPs ). Biometric heritability estimates ranged from .49 to .85, with median .78. additive effect all SNP heritability) varied across electrodes. Although individual were not...
P3 amplitude reduction (P3-AR) is associated with biological vulnerability to a spectrum of externalizing disorders, such as ADHD, conduct disorder, and substance use disorders. P3, however, generally characterized broad activation involving multiple neurophysiological processes. One approach separating P3-related processes time-frequency (TF) analysis. The current study used novel PCA-based TF analysis method investigate relationships between its components, in community-based sample...