A5017283507- Cancer-related Molecular Pathways
- Cytokine Signaling Pathways and Interactions
- Thyroid Disorders and Treatments
- Telomeres, Telomerase, and Senescence
- Cancer Research and Treatments
- Menstrual Health and Disorders
- NF-κB Signaling Pathways
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Histone Deacetylase Inhibitors Research
- Advanced Breast Cancer Therapies
- Cancer, Hypoxia, and Metabolism
- Reproductive System and Pregnancy
- Acute Myeloid Leukemia Research
- Cancer therapeutics and mechanisms
- RNA Interference and Gene Delivery
- Protein Degradation and Inhibitors
- Cognitive Abilities and Testing
- Evolutionary Psychology and Human Behavior
- Breastfeeding Practices and Influences
- Glutathione Transferases and Polymorphisms
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
Karolinska Institutet
2013-2020
Center for Vascular Biology Research
2015
Leibniz Association
2010
Max Delbrück Center
2009-2010
Charité - Universitätsmedizin Berlin
2005
Tumor cells frequently disseminate through the lymphatic system during metastatic spread of breast cancer and many other types cancer. Yet it is not clear how tumor make their way into they choose between blood vessels for migration. Here we report that mammary undergoing epithelial–mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β1) become activated targeted migration system, similar dendritic (DCs) inflammation. EMT preferentially migrated toward compared with...
During breast cancer progression, transforming growth factor-beta (TGF-β) switches from acting as a inhibitor to become major promoter of epithelial-mesenchymal transition (EMT), invasion and metastasis. However, the mechanisms involved in this switch are not clear. We found that loss CCAAT-enhancer binding protein beta (C/EBPβ), differentiation factor for mammary epithelium, was associated with signs EMT triple-negative human cancer, invasive areas tumors MMTV-PyMT mice. Using an...
Arginine-vasopressin (AVP) modulates the water channel aquaporin-2 (AQP2) in renal collecting duct to maintain homeostasis of body water. AVP binds vasopressin V2 receptors (V2R), increasing cAMP, which promotes redistribution AQP2 from intracellular vesicles into plasma membrane. cAMP also increases transcription, but whether altered degradation protein levels is not well understood. Here, elevation increased within 30 minutes primary inner medullary (IMCD) cells, human embryonic kidney...
Hypoxia inducible factor-1 α (HIF-1α) has been identified as an important novel target in apoptosis resistance of pediatric tumors such Rhabdomyosarcoma (RMS) and Ewing's sarcoma (ES). Evidence suggests that PI3K/Akt signaling plays a role regulation HIF-1α activation well various adult tumors. However the relevance HIF-1bα childhood not addressed yet. Thus, this study was to investigate whether is involved hypoxia induced hypoxia-induced RMS ES.Constitutive analyzed by Western blotting....
Breast cancer progression toward metastatic disease is linked to re-activation of epithelial-mesenchymal transition (EMT), a latent developmental process. cells undergoing EMT lose epithelial characteristics and gain the capacity invade surrounding tissue migrate away from primary tumor. However, less known about possible role in providing with properties that allow them traffic distant sites. Given fact pro-metastatic share unique immune in-and-out blood lymphatic vessels we hypothesized...
Oncogene induced senescence (OIS) is a sustained anti-proliferative response acutely in primary cells via activation of mitogenic oncogenes such as Ras/BRAF. This mechanism acts an initial barrier preventing normal transformation into malignant cell. Besides oncogenic and DNA damage (DDR), modulated by plethora other factors, one the most important oxygen tension tissue. The aim this study was to determine impact hypoxia on RasV12-induced human diploid fibroblasts (HDFs). We showed here that...
The underlying reasons why some women experience debilitating premenstrual symptoms and others do not are largely unknown. Here, we test the evolutionary ecological hypothesis that negative may be exacerbated by presence of chronic sexually transmitted infections (STIs). 34 511 were recruited through a digital period-tracker app. Participants asked: (i) Have you ever been diagnosed with STI? (ii) If yes, when was it, given treatment? Those data combined longitudinal cycle on menstrual...
The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, major barrier imposed on tumor cells early tumorigenesis. MYC key factor suppression of RAS/BRAF(V600E)-induced senescence vitro. However, it still unclear whether has the same during development vivo. Using conditional, compound knock-in model Cre-activated BRAF(V600E) and tamoxifen-regulatable MycER, we show that tamoxifen-induced activation accelerated onset increased number...
The MYC and RAS oncogenes are sufficient for transformation of normal rodent cells. This cooperativity is at least in part based on suppression RAS-induced cellular senescence by block MYC-induced apoptosis – thereby canceling out two main barriers against tumor development. However, it remains unclear whether cooperate this way human cells, where not transformation. To address question, we established a combined Tet-inducible H-RASV12 hydroxytamoxifen-inducible MycER system BJ fibroblasts....
Deregulated expression of the MYC oncogene is a frequent event during tumorigenesis and generally correlates with aggressive disease poor prognosis. While potent inducer apoptosis, it often suppresses cellular senescence, which together apoptosis an important barrier against tumor development. For this latter function, dependent on cyclin-dependent kinase 2 (CDK2). Here, we utilized MYC/BCL-XL-driven mouse model acute myeloblastic leukemia (AML) to investigate whether pharmacological...
INTRODUCTION: So far, the published data on menstrual cycle was collected by participants, through period diaries. This approach creates massive bottlenecks, where individuals with insufficient computing power can't process enough for meaningful interpretation a global scale. In addition, studies so far are mostly geo specific. Today, mobility increase, standardized charts made each region proving to be less precise, and sample size used in is too small hold claims. Moreover, most of...
Background: Three hundred fifty million people worldwide suffer from underactive thyroid conditions, which can lead to infertility, obesity, heart disease, and impaired mental health when poorly managed. Although mobile (mHealth) applications be a useful solution for self-managing one's condition, the impact of digital solutions improving patients remains unknown. Methods: We used mixed methods analysis assess ways in approach might benefit patients. A cross-sectional study was conducted...
<p>PDF file - 152K, Analysis of senescence, apoptosis and p19Arf expression in lung tissues BRAF/MYC mice.</p>
<p>PDF file - 1861K, Lung weights of BRAF/MYC mice early in disease.</p>
<p>PDF file - 6250K, Activation of BRAFV600E and MYC by Ad-Cre TAM results in development SPC-expressing lung tumors. Genomic status after Cre-mediated recombination, MycER protein expression, mouse to body weight expression differentiation antigens.</p>
<p>PDF file - 6250K, Activation of BRAFV600E and MYC by Ad-Cre TAM results in development SPC-expressing lung tumors. Genomic status after Cre-mediated recombination, MycER protein expression, mouse to body weight expression differentiation antigens.</p>
<p>PDF file - 152K, Analysis of senescence, apoptosis and p19Arf expression in lung tissues BRAF/MYC mice.</p>
<div>Abstract<p>The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, major barrier imposed on tumor cells early tumorigenesis. MYC key factor suppression of RAS/BRAF<sup>V600E</sup>-induced senescence <i>in vitro</i>. However, it still unclear whether has the same during development vivo</i>. Using conditional, compound knock-in model Cre-activated...
<div>Abstract<p>The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, major barrier imposed on tumor cells early tumorigenesis. MYC key factor suppression of RAS/BRAF<sup>V600E</sup>-induced senescence <i>in vitro</i>. However, it still unclear whether has the same during development vivo</i>. Using conditional, compound knock-in model Cre-activated...