A5049292478- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Curcumin's Biomedical Applications
- Heavy Metals in Plants
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Drug-Induced Hepatotoxicity and Protection
- Heavy Metal Exposure and Toxicity
- Phytochemicals and Medicinal Plants
- Essential Oils and Antimicrobial Activity
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
- Advanced Glycation End Products research
- Insect Pest Control Strategies
- Protein Structure and Dynamics
- Piperaceae Chemical and Biological Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Alkaloids: synthesis and pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Neonatal Respiratory Health Research
- Cannabis and Cannabinoid Research
- Phytochemistry and Bioactive Compounds
- BRCA gene mutations in cancer
Princess Nourah bint Abdulrahman University
2020-2025
Imam Mohammad ibn Saud Islamic University
2024-2025
King Saud University
2020
Chatham University
2017
Alpha-amylase is widely exploited as a drug target for preventing postprandial hyperglycemia in diabetes and other metabolic diseases. Inhibition of this enzyme by plant-derived pregnanes not fully understood. Herein, we used vitro, silico, vivo studies to provide further insights into the alpha-amylase inhibitory potential selected pregnane-rich chromatographic fractions four steroidal pregnane phytochemicals (SPPs), viz: marsectohexol (P1),...
This study employs a comprehensive approach combining protein retrieval, sequence alignment, and molecular dynamics simulations to investigate the structural stability of wild-type KRas its mutated variants (G12C, G12D, G12V, G13D). The selected structures were retrieved from Protein Data Bank (PDB) prepared by using visual (VMD) software. Sequence alignment Clustal Omega provided detailed comparison amino acid sequences, focusing on key mutation sites. Molecular simulations, performed with...
The management of diabetes over the years has involved use herbal plants, which are now attracting interest. We assessed antidiabetic properties aqueous extract
The major yield governing factors especially under rainfed ecosystem are the agro-meteorological indices. Hence, an experiment was conducted in 2021 kharif season to examine impact of nutrient omission on phenology, and indices Quality Protein Maize (QPM) North Western Himalayas India at Agronomy farm FoA (Faculty Agriculture), Wadoora, Sopore, SKUAST-Kashmir. Eight treatments were used viz. (T1-Absolute control, T2-N120P75K40, T3-N120P75K40Zn5S10, T4-P75K40Zn5S10 (-N), T5-N120K40Zn5S10...
Heat shock protein 27 (HSP27) is a that works as chaperone and an antioxidant activated by heat shock, environmental stress, pathophysiological stress. However, HSP27 dysregulation characteristic of many human cancers. suppresses apoptosis cytoskeletal reorganization. As result, it recognized critical therapeutic target for effective cancer therapy. Despite the effectiveness multiple inhibitors in pre-clinical investigations clinical trials, no inhibitor has progressed to anticancer phase...
A major paradigm shift in the field of nanobiotechnology is invention an eco-friendly, economical, and green approach for synthesis metal nanoparticles. In present study, we have synthesized gold nanoparticles (AuNPs) using aqueous extracts marine brown seaweed Sargassum longifolium. The nanoparticle was subjected to characterization different techniques such as UV-Vis spectroscopy, Fourier transform infrared atomic force microscope, scanning electron transmission elemental dispersive X-ray...
Moringa oleifera is a nutrient-rich plant, also referred to as miracle tree, and commonly used in the preparation of functional foods including herbal biscuits. Despite having wide range biomolecules, M. has not been studied for its nutritional benefits Nepal. To fill this gap, five different formulations flower leaf powder ratios 11:4, 11.75:3.25, 12.5:2.5, 13.25:1.75, 14:1 named A, B, C, D, E, control were tested their sensory chemical characteristics. The results showed that calcium...
In the present study, in vitro, vivo, and silico models were used to evaluate therapeutic potential of Pulmeria alba methanolic (PAm) extract, we identified major phytocompound, apigetrin. Our vitro studies revealed dose-dependent increased glucose uptake inhibition α-amylase (50% inhibitory concentration (IC50)= 217.19 µg/mL), antioxidant (DPPH, ferric-reducing activity plasma (FRAP), lipid peroxidation (LPO) [IC50 = 103.23, 58.72, 114.16 µg/mL respectively]), anti-inflammatory (stabilizes...
Background: The present study was carried out to test the antioxidant activity of lactoferrin as a dietary supplement alleviate effects oxidative stress induced by mercury toxicity. Hematological and biochemical assays were employed evaluate ameliorating lactoferrin. Methods: Sixty male Wistar rats allotted randomly equally into three groups; animals in Group 1 served untreated control, 2 administered orally with mercuric chloride (HgCl ) at dose 6 mg/kg bw/day, 3 HgCl same dosed (400...
Cyclophosphamide (CP) alkylates DNA and RNA produce crosslinks that cause gene expression protein synthesis inhibition to exert its anticancer effect. However, adverse effects of CP have restricted the application in cancer treatment. We investigate coenzyme-Q10 (Q10) piperine (P) protective role on oxidant inflammatory HuH-7 cells were exposed varying concentrations combinations Q10, P, evaluated intracellular ROS generation as well responses upon exposure. Our results showed Q10 and/or P...
Chemotherapy resistance remains a significant challenge in treating ovarian cancer effectively. This study addresses this issue by utilizing dual drug-loaded nanomicelle system comprising albendazole (ABZ) and paclitaxel (PTX), encapsulated novel carrier matrix of D-tocopheryl polyethylene glycol 1000 succinate vitamin E (TPGS), soluplus folic acid. Our objective was to develop optimize nanoparticulate delivery using solvent evaporation techniques enhance the therapeutic efficacy against...
Tetracarpidium conophorum nuts are nutrient-dense Nigerian snacks associated with weight regulation. This study explores the nuts' impact on adipose tissue gene expression low-grade inflammation. Ethanol whole extract (EWE), ethyl-acetate fraction (EAF) and resulting residue (RES) were orally administered once daily to MSG-induced obese rats for 6 weeks (n = 6). Afterward, RNA synthesis of inflammation-associated genes was measured, GC-MS ligands in fractions docked against their protein...
The Oleaceae family, encompassing key genera such as Fraxinus (ash trees), Olea (olives), Jasminum (jasmine), Syringa (lilac), and Forsythia, plays a crucial ecological economic role. Despite their importance, the evolutionary dynamics immune system adaptations of NLR (Nucleotide binding leucine-rich repeats) gene family remain largely unexplored. This study employs high-throughput comparative genomics to investigate evolution across family. genus is widely distributed both New Old Worlds,...
Background: Lycopene is a phytochemical exhibiting wide range of health benefits and bioactivities. The present study focuses on lycopene’s in vivo antioxidant properties evaluates the efficiency dietary lycopene supplements alleviating cadmium-induced oxidative stress. Methods: experimental rats were divided randomly into four groups (n=20): untreated control, lycopene-treated, cadmium-exposed cadmium-lycopene groups. Result: Lycopene-accessed revealed improvements both haematological...
Introduction: Synergy is defined as an interaction of some substances that cooperate to give rise the combined effect greater than sum their individual effects. It a natural strategy has evolved by nature more efficacy with low cost. Methods: This study designed evaluate chemopreventive drug sample which prepared mixing equal portion stigmasterol and palmatine isolated from Azadirachta indica Tinospora cordifolia respectively at concentration 100 mg/kg 200 body weight during whole...