A5016107878- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Renal and Vascular Pathologies
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Organ and Tissue Transplantation Research
- Pediatric Hepatobiliary Diseases and Treatments
- Metabolism and Genetic Disorders
- Healthcare Policy and Management
- Hepatitis C virus research
- Palliative Care and End-of-Life Issues
- Dialysis and Renal Disease Management
- Pharmacological Effects and Toxicity Studies
- Blood donation and transfusion practices
- Gallbladder and Bile Duct Disorders
- Liver Diseases and Immunity
- Cytomegalovirus and herpesvirus research
- Grief, Bereavement, and Mental Health
- Statistical Methods and Inference
- Neurological Complications and Syndromes
University of Michigan
2012-2024
Arbor Research Collaborative for Health
2014-2024
E Ink (South Korea)
2022
Michigan United
1991-2022
University of Pittsburgh
2020
Ann Arbor Center for Independent Living
2002-2019
International Society for Heart and Lung Transplantation
2016
OWL (Spain)
2016
Medical Research Foundation
2016
Directorate-General for Interpretation
2016
Transplantation of nonrenal organs is often complicated by chronic renal disease with multifactorial causes. We conducted a population-based cohort analysis to evaluate the incidence failure, risk factors for it, and associated hazard death in recipients transplants.Pretransplantation post-transplantation clinical variables data from registry patients end-stage (ESRD) were linked order estimate cumulative failure (defined as glomerular filtration rate 29 ml per minute 1.73 m2 body-surface...
We propose a continuous kidney donor risk index (KDRI) for deceased kidneys, combining and transplant variables to quantify graft failure risk.By using national data from 1995 2005, we analyzed 69,440 first-time, kidney-only, adult transplants. Cox regression was used model the of death or loss, based on factors, adjusting recipient factors. The proposed KDRI includes 14 each found be independently associated with death: age, race, history hypertension, diabetes, serum creatinine,...
Demand for liver transplantation continues to exceed donor organ supply. Comparing recipient survival that of comparable candidates without a transplant can improve understanding benefit. Waiting list and post-transplant mortality was studied among cohort 12 996 adult patients placed on the waiting between 2001 2003. Time-dependent Cox regression models were fitted determine relative rates recipients. Overall, deceased recipients had 79% lower risk than (HR = 0.21; p < 0.001). At Model...
Background. Availability of cadaveric kidneys for transplantation is far below the growing need, leading to longer waiting time and more deaths while waiting. Methods. Using national data from 1995 2000, we evaluated graft survival by donor characteristics rate discard retrieved organs, with goal increasing use that are associated increased risk failure, is, expanded kidneys. Results. Cox models identified four factors independently predicted significantly higher relative loss compared a...
Context Transplantation using kidneys from deceased donors who meet the expanded criteria donor (ECD) definition (age Ն60 years or 50 to 59 with at least 2 of following: history hypertension, serum creatinine level Ͼ1.5 mg/dL [132.6 µmol/L], and cerebrovascular cause death) is associated 70% higher risk graft failure compared non-ECD transplants.However, if ECD transplants offer improved overall patient survival, inferior outcome may represent an acceptable trade-off.Objective To compare...
In 1999, the Institute of Medicine suggested that instituting a continuous disease severity score de-emphasizes waiting time could improve allocation cadaveric livers for transplantation. This report describes development and initial implementation this new plan. The goal was to develop scale uses objective, readily available variables predict mortality risk in patients with end-stage liver reduce emphasis on time. Mechanisms were also developed inclusion good transplant candidates who do...
Kidney transplantation is the most desired and cost-effective modality of renal replacement therapy for patients with irreversible chronic kidney failure (end-stage disease, stage 5 disease). Despite emerging evidence that best outcomes accrue to who receive a transplant early in course therapy, only 2.5% incident end-stage disease undergo as their initial treatment, figure largely unchanged at least decade.
Liver allocation policy in the U.S. was recently changed to a continuous disease severity scale with minimal weight given time waiting an effort better prioritize deceased donor liver transplant candidates. We compared rates of list registrations, removals, transplants, and deaths during year prior implementation new (2/27/01-2/26/02, Era 1) first year's experience (2/27/02-2/26/03, 2) under this policy. Rates were adjusted for 1,000 patient years on using z-tests. A 1-sided test used...
Elderly patients (ages 70 yr and older) are among the fastest-growing group starting renal-replacement therapy in United States. The outcomes of elderly who receive a kidney transplant have not been well studied compared with those their peers on waiting list.Using Scientific Registry Transplant Recipients, we analyzed data from 5667 renal candidates initially were wait-listed January 1, 1990 to December 31, 2004. Of these candidates, 2078 received deceased donor transplant, 360 living by 31...
CYP3A4, a major Phase I xenobiotic metabolizing enzyme present in liver, is also human small bowel epithelium where it appears to catalyse significant 'first pass' metabolism of some drugs. To determine whether CYP3A4 or the related enzymes CYP3A3, CYP3A5, and CYP3A7 are other regions digestive tract, we used CYP3A-specific antibodies examine histological sections epithelial microsomes obtained from organ donor. CYP3A-related proteins were detected epithelia throughout tract gastric parietal...
The objective of this study was to characterize the patient population with respect selection, assess surgical morbidity and graft failures, analyze contribution perioperative clinical factors recipient outcome in adult living donor liver transplantation (ALDLT).Previous reports have been center-specific or from large databases lacking detailed variables. Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) represents first North American multicenter report risk aiming...
A wider application of living donor liver transplantation is limited by morbidity concerns. An observational cohort 760 donors accepted for surgery and enrolled in the Adult-to-Adult Living Donor Liver Transplantation study provides a comprehensive assessment incidence, severity natural history donation (LLD) complications. (assessed 29 specific complications), predictors, time from to complications complication onset resolution were measured outcomes over 12-year period. Out procedures, 20...
The survival benefit of liver transplantation depends on candidate disease severity, as measured by MELD score. However, donor quality may also affect benefit. Using US data from the SRTR 28 165 adult transplant candidates wait-listed between 2001 and 2005, we estimated according to cross-classifications score deceased risk index (DRI) using sequential stratification. Covariate-adjusted hazard ratios (HR) were calculated for each recipient at a given with an organ DRI, comparing...
Using a retrospective analysis we compared 79 recipients of cadaveric renal allografts who were treated with cyclosporine as the sole initial immunosuppressant and 29 concurrent transplant conventional immunosuppressants. The cyclosporine-treated group had slightly higher actuarial patient survival at four years (86 per cent vs. 76 cent). Actuarial graft was 70 in group, 62 conventionally immunosuppressed group. incidence acute rejection episodes 62.1 former 65.5 latter. Nephrotoxicity...
Posttransplant patient and graft survival outcomes have improved over the past decade for almost every organ.
A consensus meeting to develop guidelines that would improve the recovery and transplantation of organs from cadaver donor was held on 28–29 March 2001, in Crystal City, Virginia, sponsored by American Society Transplant Surgeons Transplantation. The crisis organ supply persists continuing shortage presents a compelling responsibility for transplant community maximize use procured donors.
ABSTRACT The pharmacokinetics of an orally administered valine ester ganciclovir (GCV), valganciclovir (VGC), were studied. These compared to the oral and intravenous GCV. Twenty-eight liver transplant recipients received, in open-label random order with a 3- 7-day washout, each following: 1 g GCV three times day; 450 mg VGC per os (p.o.) once day (q.d.); 900 p.o. q.d.; 5 (i.v.) kg body weight q.d., given over h. concentrations measured blood 24 One-sided equivalence testing was performed...
Background. Laparoscopic live donor nephrectomy for renal transplantation is being performed in increasing numbers with the goals of broadening organ supply while minimizing pain and duration convalescence donors. Relative advantages terms recovery provided by laparoscopy over standard open surgery have not been rigorously assessed. We hypothesized that laparoscopic as compared surgical provides briefer, less intense, more complete convalescence. Methods. Of 105 volunteer, adult, potential...
The success of renal transplantation may be counterbalanced by serious adverse medical events. effect immunosuppression on the incidence de novo neoplasms among kidney recipients should monitored continuously. Using data from Scientific Registry Transplant Recipients, we studied association induction therapy with antilymphocyte antibodies, development neoplasms. study population included more than 41 000 who received a cadaveric first transplant after December 31, 1995, and were followed...