A5100414094- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Chronic Myeloid Leukemia Treatments
- Sports Performance and Training
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Galectins and Cancer Biology
- Lung Cancer Research Studies
- Immune cells in cancer
- Cancer Diagnosis and Treatment
- Winter Sports Injuries and Performance
- Genomics, phytochemicals, and oxidative stress
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Bioinformatics and Genomic Networks
Heilongjiang Provincial Hospital
2023
Hebei Medical University
2023
Xingtai People's Hospital
2023
Shandong First Medical University
2023
Academy of Medical Sciences
2023
Shandong Tumor Hospital
2023
First Affiliated Hospital of GuangXi Medical University
2023
Guangxi Medical University
2023
Central South University
2023
Qinghai University
2023
Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression profiling and mining potential correlation between genes overall survival a variety malignancies including GBM. Previous reports have shown that tumor microenvironment cells extent infiltrating immune stromal in tumors contribute significantly prognosis. Immune scores calculated based on ESTIMATE algorithm could facilitate...
Abstract Objective: We aimed to investigate the relationship between titin (TTN) gene mutations and thyroid cancer (THCA) explore feasibility of TTN as a potential prognostic indicator THCA. Methods: From TCGA-THCA cohort, we performed series analyses evaluate value mechanism in These patients were divided into mutant-type (MUT) group wild-type (WT) group. Differentially expressed genes (DEGs) two groups screened using ‘DESeq2’ R package. Functional enrichment analysis was performed,...
This study focused on identifying bladder cancer (BC)-associated genes, transcription factors (TFs), and microRNAs (miRNAs). Two microarray data sets GSE37815 GSE40355 were utilized to screen common differentially expressed genes (DEGs) associated with BC. Then, functional enrichment analysis was performed for elucidating the involved functions of DEGs. Subsequently, protein–protein interaction (PPI) network submodule PPI analyzed. Finally, regulation relationships TF–DEGs miRNA–DEGs...
Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children adolescents. The pathognomonic oncofusion EWSR1::FLI1 transcription factor drives EwS by orchestrating an oncogenic program through de novo enhancers. By integrative analysis thousands transcriptomes representing pan-cancer cell lines, primary cancers, metastasis, normal tissues, we identify 32-gene signature (ESS32 [Ewing Sarcoma Specific 32]) stratifies from pan-cancer. Among the ESS32,...
The primary or acquired resistance to anti-VEGF inhibitors remains a common problem in cancer treatment. Therefore, identifying potential biomarkers enables better understanding of the precise mechanism. Through GEO database, three profiles associated with bevacizumab (BV) ovarian cancer, glioma, and non-small-cell lung carcinoma, respectively, were collected for screening process, two genes found. A-kinase anchor protein 12 (AKAP12), one these genes, correlates tumorigenesis some cancers....
Pyrocytosis is involved in the development of abdominal aortic aneurysm (AAA), we explored pyrocytosis-related hub genes AAA and conducted a diagnostic model based on score (PRGs). A total 2 bulk RNA-seq (GSE57691 GSE47472) datasets were integrated to obtain 24 different expression (DEGs). The LASSO Cox regression analysis was filter out 7 further establish nomogram signature PRGs that exhibited good diagnosis value. Weighted gene co-expression network (WGCNA) established 14 modules...
Procollagen-lysine, 2-oxoglutarate 5-dioxygenases (PLODs) are a family of enzymes. However, the clinical and functional roles PLOD3 in colon adenocarcinoma (COAD) have not been investigated. The present study found that was highly upregulated COAD, which may be resulted from its aberrant DNA methylation. upregulation both mRNA protein confirmed our tissue samples. Moreover, high identified to associated with unfavorable prognosis COAD. As genome instability is hallmark cancer, expressed...
Previous documents have reported that the deoxythymidylate kinase (DTYMK) genes were involved in progression of cancers. However, its significance analysis pan-cancer and specific molecular mechanism still poorly understood. In present study, we conducted a comprehensive study DTYMK gene associated with clinical relevance across broad-spectrum human tumors. addition, association among tumor immunogenic features was also explored. Considering results analysis, lung adenocarcinoma (LUAD)...
Accumulating evidence suggests that aging and senescence play crucial roles in tumorigenesis, cancer progression, treatment. However, the influence of senescence-related genes (ASRGs) on clinical outcomes treatment options lung adenocarcinoma (LUAD) patients remains unknown. Here, we developed an scoring system, ASRS, by integrating bulk transcriptome data from 22 LUAD datasets. In 3,243 samples, higher ASRS scores were associated with poor tumor stage pathological grade, as well shorter...
Abstract Cuproptosis is a newly reported type of programmed cell death that involved in the progression various diseases. Some studies have its potential significance multiple tumors. Colorectal cancer (CRC) one malignant tumors with high incidence and mortality. The purpose this study was to further explore importance cuproptosis CRC development treatment. We analyzed expression, alterations, promoter methylation cuproptosis‑related genes (CRGs) patients CRC. Three machine learning methods...
Tumor-associated macrophages are important components of the tumor microenvironment, and macrophage phenotypic switch has been shown to correlate with development. However, use a switch-related gene (MRG)-based prognosis signature for lung adenocarcinoma (LADC) not yet investigated. In total, 1,114 LADC cases from two different databases were collected. The samples TCGA used as training set (N = 490), whereas independent datasets (GSE31210 GSE72094) GEO database validation sets 624). A...
Abstract Hepatocellular carcinoma (HCC) is a common lethal gastrointestinal cancer worldwide. Despite the involvement of T-cell exhaustion and mitochondrial dysfunction in HCC progression, there are no reliable biomarkers for these processes. In this study, we aimed to develop gene signature that combines exhaustion- (TEMD)-related genes predict prognosis direct immunotherapy chemotherapy. Data 240 370 patients were obtained from International Cancer Genome Consortium database as well Atlas,...
Supplementary Figure 1 Legend from Imatinib Mesylate Induces Quiescence in Gastrointestinal Stromal Tumor Cells through the CDH1-SKP2-p27<sup>Kip1</sup> Signaling Axis
<title>Abstract</title> <bold>Background</bold> Multimerin 1 (MMRN1) is a factor V binding protein, which could support platelet adhesion and thrombus formation. In recent years, the role of MMRN1 in cancer has begun to attract attention. But systematic studies this area are lacking. Therefore, we used bioinformatics methods analyze tumors reveal possible MMRN1.<bold>Methods</bold> Using Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) database, obtained relevant data for...
<div>Abstract<p>Gastrointestinal stromal tumors (GIST) are caused by activating mutations in the KIT or platelet-derived growth factor receptor α tyrosine kinase genes. Approximately 85% of GIST patients treated with imatinib mesylate achieve disease stabilization, however, often presence residual tumor masses. Complete remissions rare and a substantial proportion develop resistance to imatinib. Our study was designed determine whether imatinib-associated responses may account...
PURPOSE: The purpose of this study was to generate a zone normality (ZON) based upon ratings perceived exertion (RPE) estimated during each stage progressively incremented treadmill test. RPE responses graded tests administered patients with coronary artery disease (CAD) were then compared the ZON. METHODS: Forty five healthy adult (34.8 ± 9.1 yr) women completed Bruce Treadmill RPE's (Borg 15 category scale) last min and at test termination. Regression analysis used establish relation...
Abstract Background A novel type of cell death induced by intracellular copper accumulation, principally different from other known ones such as autophagy, ferroptosis, and pyroptosis, was discovered referred to “Cuproptosis” recently. As the underlying mechanism newly identified, its potential connection pancreatic adenocarcinoma (PAAD) is still an open issue. However, interestingly, one 10 Cuproptosis-related genes, CDKN2A, previously reported a driver mutation gene in adenocarcinoma....
Abstract OBJECTIVE: To compare the safety and effectiveness of robot-assisted partial nephrectomy (RAPN) versus laparoscopic (LPN) in treatment central renal angiomyolipomas (AMLs). METHODS: We retrospectively analyzed clinical data 103 patients who were treated with either RAPN or LPN for between January 2017 June 2022. Propensity scores matched according to sex, age, laterality, body mass index (BMI), symptoms, diameter tumor, location tumor distribution, RENAL score, preoperative...