A5019732083- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Zebrafish Biomedical Research Applications
- Hematopoietic Stem Cell Transplantation
- DNA Repair Mechanisms
- RNA modifications and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related Molecular Pathways
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Telomeres, Telomerase, and Senescence
- Signaling Pathways in Disease
- Sepsis Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Cancer-related gene regulation
- Nuclear Structure and Function
- Caveolin-1 and cellular processes
- Cancer Research and Treatments
Karolinska Institutet
2013-2019
Goethe University Frankfurt
2015
Georg Speyer Haus
2006-2014
We identified the far upstream element binding protein 1 (FBP1), an activator of transcription proto-oncogene c-myc, in a functional yeast survival screen for tumor-related antiapoptotic proteins and demonstrated strong overexpression FBP1 human hepatocellular carcinoma (HCC). Knockdown HCC cells resulted increased sensitivity to apoptotic stimuli, reduced cell proliferation, impaired tumor formation mouse xenograft transplantation model. Interestingly, analysis gene regulation these...
Abstract Overcoming cellular growth restriction, including the evasion of senescence, is a hallmark cancer. We report that PAK4 overexpressed in all human breast cancer subtypes and associated with poor patient outcome. In mice, MMTV-PAK4 overexpression promotes spontaneous mammary cancer, while gene depletion delays MMTV-PyMT driven tumors. Importantly, prevents senescence-like arrest cells vitro, vivo ex vivo, but not needed non-immortalized cells, untransformed epithelial abrogates...
The Far Upstream Element [FUSE] Binding Protein 1 (FUBP1) regulates target genes, such as the cell cycle regulators MYC and p21. FUBP1 is up-regulated in many tumours acts an oncoprotein by stimulating proliferation inhibiting apoptosis. Recently, mutations were identified approximately 15% of oligodendrogliomas. To date, all reported have been predicted to inactivate FUBP1, which suggests that contrast most other may act a tumour suppressor oligodendrogliomas.As no data are currently...
The far upstream element binding protein (FBP) and the FBP-interacting repressor (FIR) represent molecular tools for transcriptional fine tuning of target genes. Strong overexpression FBP in human hepatocellular carcinoma (HCC) supports tumor growth correlates with poor patient prognosis. However, role FIR hepatocarcinogenesis remains poorly delineated. We show that dedifferentiation cell proliferation about 60% primary HCCs. Elevated levels are associated genomic gains gene locus at...
Survivin appears to function as a regulator of cell division and an apoptosis inhibitor in many species. Here, we characterized the nucleocytoplasmic transport mouse survivin 140 , its splice variants 121 40 . We show that dynamic intracellular localization is mediated by Crm1‐dependent nuclear export signal (NES) present also but absent In contrast, neither nor contain active import seem enter nucleus passive diffusion. The activity NES required for survivin‐mediated protection against...
Abstract The systemic inflammatory response syndrome and subsequent organ failure are mainly driven by activated neutrophils with prolonged life span, which is believed to be due apoptosis resistance. However, detailed underlying mechanisms leading neutrophil resistance largely unknown, possible therapeutic options overcome this do not exist. Here we report that from severely injured patients exhibit cell death impaired activation of the intrinsic pathway, as evidenced limited...