A5082651793- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
- Crustacean biology and ecology
- Cephalopods and Marine Biology
- Olfactory and Sensory Function Studies
- Neuroscience and Neural Engineering
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Electrochemical sensors and biosensors
- Biochemical Analysis and Sensing Techniques
- Zebrafish Biomedical Research Applications
- Regulation of Appetite and Obesity
University at Buffalo, State University of New York
2017-2024
Bowling Green State University
2014-2018
Central norepinephrine (NE) and dopamine (DA) are involved in a variety of physiological functions behaviors. Accumulating evidence suggests that NE neurons originating from the locus coeruleus (LC) innervate DA ventral tegmental area (VTA) influence VTA-DA neural activity. However, underlying mechanisms how LC-NE regulates transmission via remain largely unexplored. Herein, we investigated electrical stimulation LC modulates neurotransmission nucleus accumbens (NAc). For this study,...
Amylin, a pancreatic hormone that is cosecreted with insulin, has been highlighted as potential treatment target for obesity. Amylin receptors are distributed widely throughout the brain and coexpressed on mesolimbic dopamine neurons. Activation of amylin known to reduce food intake, but neurochemical mechanisms behind this remain be elucidated. receptor activation in ventral tegmental area (VTA), key dopaminergic nucleus reward system, potent ability suppress intake palatable fat sugar...
The olfactory tubercle (OT), an important component of the ventral striatum and limbic system, is involved in multi-sensory integration reward-related information brain. However, its functional roles are often overshadowed by neighboring nucleus accumbens. Increasing evidence has highlighted that dense dopamine (DA) innervation OT from tegmental area (VTA) implicated encoding reward, natural reinforcers, motivated behaviors. Recent studies have further suggested subregions may distinct these...
Abstract Methamphetamine (METH) is a potent psychostimulant that exerts many of its physiological and psychomotor effects by increasing extracellular dopamine (DA) concentrations in limbic brain regions. While several studies have focused on how potent, neurotoxic doses METH augment or attenuate DA transmission, the acute lower behaviorally activating modulating regulation (release clearance) through D2 autoreceptors transporters remain to be elucidated. In this study, we investigated...
Research in crustaceans offers a valuable perspective for studying the neural implementation of conserved behavioral phenomena, including motivation, escape, aggression, and drug-sensitive reward. The present work adds to this literature by demonstrating that crayfish successfully learn respond spatially contingent cues. An integrated video-tracking system automatically delivered mild electric shock when test animal entered or remained on substrate paired with punishment. Following few...
Methamphetamine (METH) is a psychostimulant that primarily exerts its effects on the catecholamine (dopamine (DA) and norepinephrine (NE)) systems, which are implicated in drug addiction. METH exists as two distinct enantiomers, dextrorotatory (d) levorotatory (l). In contrast to d-METH, major component of illicit used induce states euphoria alertness, l-METH available without prescription nasal decongestant has been highlighted potential agonist replacement therapy treat stimulant use...
Norepinephrine (NE), one of the major catecholamines in brain, is involved many physiological and behavioral processes such as stress reward. Despite its important roles, NE remains largely unexplored compared to other central catecholamine, dopamine (DA). This due part diffuse distribution projections throughout brain accessibility neurons, complicating detection relatively low concentrations. Recent studies have demonstrated that vivo fast-scan cyclic voltammetry coupled with carbon-fiber...
Recent studies show that dense dopamine (DA) innervation from the ventral tegmental area to olfactory tubercle (OT) may play an important role in processing multisensory information pertaining arousal and reward, yet little is known about DA regulation OT. This mainly due anatomical limitations of conventional methods determining dynamics small heterogeneous OT subregions located most part brain. Additionally, there increasing awareness anteromedial anterolateral have distinct functional...
Abstract Central dopamine (DA) innervation of the olfactory tubercle (OT) from ventral tegmental area (VTA) plays a critical role in encoding multisensory information and generating behavioral outputs necessary for survival. However, due to anatomical restrictions neurochemical heterogeneity VTA OT, very little is known about functional link between mesolimbic VTA-DA transmission OT its mediating reward drug seeking. In this study, we integrated vivo fast-scan cyclic voltammetry with...
Norepinephrine (NE), one of the major catecholamines in brain, is involved many physiological processes and behaviors ranging from fear anxiety to reward. Despite its important roles, NE has largely been unexplored compared other central catecholamine, dopamine (DA). This due part diffuse distribution projections throughout brain challenges low concentration anatomy, complicating detection. Specifically, ordinarily two orders magnitude lower than that DA rodent regions have appreciable...
Electroanalytical methods, especially, fast-scan cyclic voltammetry (FSCV) coupled with carbon-fiber microelectrodes, have been widely used to study rapid changes in neurochemical concentrations and provide a local view of neurotransmission real time. However, electroanalytical methods alone are limited understand the distinct roles neural circuits different brain areas or even subregions same area. In recent years, development novel genetic approaches such as optogenetics chemogenetics made...