A5081045733- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Genomics and Chromatin Dynamics
- Cell Image Analysis Techniques
- Bioinformatics and Genomic Networks
- Tryptophan and brain disorders
- Cancer-related gene regulation
- Redox biology and oxidative stress
- Single-cell and spatial transcriptomics
Columbia University Irving Medical Center
2022-2023
Columbia University
2023
Rutgers, The State University of New Jersey
2021
The interplay between metabolism and chromatin signaling is implicated in cancer progression. However, whether how metabolic reprogramming tumors generates vulnerabilities remain unclear. Lung adenocarcinoma (LUAD) frequently harbor aberrant activation of the NRF2 antioxidant pathway, which drives aggressive chemo-resistant disease. Using a chromatin-focused CRISPR screen, we report that sensitizes LUAD cells to genetic chemical inhibition class I histone deacetylases (HDACs). This...
Abstract Interplay between metabolism and chromatin signaling have been implicated in cancer initiation progression. However, whether how metabolic reprogramming tumors generates specific epigenetic vulnerabilities remain unclear. Lung adenocarcinoma (LUAD) frequently harbor mutations that cause aberrant activation of the NRF2 antioxidant pathway drive aggressive chemo-resistant disease. We performed a chromatin-focused CRISPR screen report sensitized LUAD cells to genetic chemical...