A5117304297- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
Center for Discovery
2025
Hackensack Meridian Health
2025
Robust mouse models of chronic infection with Mycobacterium abscessus, an environmental pathogen that preferably infects the lungs, are badly needed. Year-long multidrug therapies deliver unacceptably poor cure rates in patients, around 50%, hence need for predictive preclinical tools to develop better antibiotics. However, immunocompetent mice generally resistant pulmonary by M. abscessus. Numerous attempts establish a sustained abscessus have been reported literature. Among these, methods...
Mycobacterium abscessus is a rapidly growing nontuberculous causing severe pulmonary infections, especially in immunocompromised individuals and patients with underlying lung conditions like cystic fibrosis (CF). While rifamycins are the pillar of tuberculosis treatment, their efficacy against M. disease severely compromised by intrabacterial ADP-ribosylation. Additionally, induce cytochrome P450 3A4 (CYP3A4), major human drug-metabolizing enzyme, further limiting use comorbidities that...