A5057467265- Aerogels and thermal insulation
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Surface Modification and Superhydrophobicity
- Microbial Natural Products and Biosynthesis
- Synthetic Organic Chemistry Methods
- Mesoporous Materials and Catalysis
- Click Chemistry and Applications
- Catalysis and Oxidation Reactions
- Synthesis and Catalytic Reactions
- Chemical Reactions and Isotopes
- Polymer composites and self-healing
- Marine Sponges and Natural Products
- Peptidase Inhibition and Analysis
- Sesquiterpenes and Asteraceae Studies
- Chemical synthesis and alkaloids
- Catalytic C–H Functionalization Methods
- Railway Systems and Energy Efficiency
- Advanced Sensor and Energy Harvesting Materials
- Biotin and Related Studies
- Advanced Cellulose Research Studies
- Supercapacitor Materials and Fabrication
- Ubiquitin and proteasome pathways
- Cyclopropane Reaction Mechanisms
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2015-2024
Linde (Germany)
2015
University of Basel
2012-2015
Institut Català d'Investigació Química
2013
TU Dortmund University
2007-2010
Max Planck Institute of Molecular Physiology
2007-2010
Max Planck Society
2007
Over the past decade, asymmetric aminocatalysis has become a reliable synthetic platform for generating stereogenic centres at α and β positions of unmodified carbonyl compounds with very high fidelity. More recently, chemists have interested in using targeting stereocentres even more remote from catalyst's point action. The key to success is ability amine catalyst propagate electronic effects inherent aminocatalytic reactivity modes (i.e. HOMO-raising LUMO-lowering activating effects)...
The fundamental role played by actin in the regulation of eukaryotic cell maintenance and motility renders it a primary target for small-molecule intervention. In this arena, class potent cytotoxic cyclodepsipeptide natural products has emerged over last quarter-century to stimulate fields biology chemistry with their unique actin-stabilizing properties complex peptide−polyketide hybrid structures. Despite considerable research effort, structural basis activity these secondary metabolites...
Abstract Enantioselective hydrogenation of furans and benzofurans remains a challenging task. We report the 2‐ 3‐substituted by using iridium catalysts that bear bicyclic pyridine–phosphinite ligands. Excellent enantioselectivities high conversions were obtained for monosubstituted with 3‐alkyl or 3‐aryl group. Furans substituted at 2‐position 2,4‐disubstituted proved to be more difficult substrates. The best results (80–97 % conversion, 65–82 enantiomeric excess) 2‐alkylfurans...
The study of classical ring-closing metathesis and relay in a total synthesis Jasplakinolide its desbromo analog is described.
The synthesis of a focused library jasplakinolide analogs with 1,2,3-triazole in place an E-configured double bond is described, featuring the Cu(I) catalyzed azide–alkyne cycloaddition reaction as efficient macrocyclization tool.
Mit einer E-selektiven Ringschlussmetathese als Schlüsselschritt gelang die festphasengestützte Totalsynthese des zellgängigen F-Aktin-Stabilisators Chondramid C, dessen bis dato unbekannte Stereochemie ebenfalls aufgeklärt wurde. In zellulären Assays stellte sich ein starker Einfluss der Polyketidkonfiguration auf Stabilisierungswirkung heraus, und Dockingstudien F-Aktin-Filaments führten zu einem detaillierten Modell Bindungstasche. Detailed facts of importance to specialist readers are...
In materials research, the control of wettability is important for many applications. Since they are typically based on phenolics, organic aerogels, and xerogels intrinsically hydrophilic in nature, examples chemical functionalization such gels scarce often limited to powders. This study reports silylation monolithic resorcinol-formaldehyde (RF) using solutions silyl chlorides triflates, respectively, combination with an amine base. The resulting structurally characterized by means elemental...
In this Communication, one image of the analysis cellular phenotypes chondramide C diastereoisomers was wrongly processed (panel in Figure 1). An improved figure with additional scale bars can be found below. The authors deeply apologize for oversight and confirm that it does not affect any hypothesis or conclusions outlined original paper. Actin stabilization BSC-1 cells monitored by whole cell fluorescence microscopy (magnification 40×) after staining actin (red, TRITC-phalloidin, Sigma)...
The title compound, C 25 H 29 NO 3 , was prepared in the course of generation depsipeptide libraries resembling Jasplakinolide family natural products. dihedral angle between phenyl ring planes is 74.1 (3)° oxazolidinone adopts a slightly distorted 4 E conformation with an axial projection isopropyl substituent, which easily rationalized by pseudo-allylic strain exerted exocyclic imide carbonyl. two carbonyl groups adopt noncolinear S-shaped conformation.
In dieser Zuschrift wurde ein Teilbild der Analyse zellulärer Phänotypen von Chondramid-C-Diastereomeren falsch verarbeitet (Teilbild C in Abbildung 1). Eine verbesserte mit zusätzlichen Maßstabsbalken ist hier gezeigt. Die Autoren entschuldigen sich für dieses Versehen und versichern, dass die Originalarbeit dargestellten Hypothesen Schlussfolgerungen dadurch nicht beeinträchtigt werden. Beobachtung Aktinstabilisierungsphänotypen BSC-1 Zellen durch Ganzzell-Fluoreszenzmikroskopie (40fache...
Abstract Phenolic aerogels based on resorcinol‐formaldehyde (RF) are among the best thermally insulating materials. However, hydrophilicity inherent to free phenolic moiety of RF gels generally limits their actual range applications. Prior efforts render hydrophobic restricted post‐synthetic functionalizations hydrophilic gels, processes that often limited in efficiency, scope, and/or longevity. Here, an acid‐mediated conversion 1,3,5‐trimethoxybenzene with formaldehyde is reported, yielding...
Abstract Invited for the cover of this issue is group Andreas Pfaltz at University Basel. The image depicts catalytic reaction used as a key step in synthesis thespesone, embellished with drawing plant from which natural product was isolated. Read full text article 10.1002/chem.201404903 .
Abstract Excellent enantioselectivities and high conversions are achieved for 3‐substituted furans (I) 2‐substituted benzofurans (VII).