A5073048968- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Corrosion Behavior and Inhibition
- Neuroscience and Neural Engineering
- Photonic and Optical Devices
- biodegradable polymer synthesis and properties
- Advanced Sensor and Energy Harvesting Materials
- Enzyme Production and Characterization
- Semiconductor Lasers and Optical Devices
- Molecular Junctions and Nanostructures
- Endodontics and Root Canal Treatments
- Conducting polymers and applications
- Semiconductor materials and devices
- Surface Modification and Superhydrophobicity
- Alkaline Phosphatase Research Studies
- Analytical Chemistry and Sensors
- Polysaccharides Composition and Applications
- Bone and Dental Protein Studies
- Laser Material Processing Techniques
- Polyoxometalates: Synthesis and Applications
- Optical Coherence Tomography Applications
- Synthesis and properties of polymers
- Synthetic Organic Chemistry Methods
Ghent University
2016-2025
Imec the Netherlands
2012-2021
IMEC
2012-2019
In recent years, research efforts in the field of ordered mesoporous materials are shifting towards either hybrid materials, containing both inorganic (typically silica) and organic functionalities, or variants that do not contain silica at all. Promising examples periodic organosilicas (PMOs); non-siliceous carbons, polymers metal oxides. They can be further tuned to obtain structures with a wide range functional groups, candidates for applications adsorption, catalysis, sensoring,...
Abstract Alkaline phosphatase (ALP), an enzyme involved in mineralization of bone, is incorporated into three hydrogel biomaterials to induce their with calcium phosphate (CaP). These are collagen type I, a mussel‐protein‐inspired adhesive consisting PEG substituted catechol groups, cPEG, and the PEG/fumaric acid copolymer OPF. After incubation Ca‐GP solution, FTIR, EDS, SEM, XRD, SAED, ICP‐OES, von Kossa staining confirm CaP formation. The amount mineral formed decreases order cPEG >...
Hydrogels of biocompatible calcium-crosslinkable polysaccharide gellan gum (GG) were enriched with bioglass particles to enhance (i) mineralization calcium phosphate (CaP); (ii) antibacterial properties and (iii) growth bone-forming cells for future bone regeneration applications.
Mineralization of hydrogels, desirable for bone regeneration applications, may be achieved enzymatically by incorporation alkaline phosphatase (ALP). ALP-loaded gellan gum (GG) hydrogels were mineralized incubation in mineralization media containing calcium and/or magnesium glycerophosphate (CaGP, MgGP). with CaGP:MgGP concentrations 0.1:0, 0.075:0.025, 0.05:0.05, 0.025:0.075 and 0:0.1 (all values mol/dm3, denoted A, B, C, D E, respectively) compared. Mineral formation was confirmed IR...
Ultra-violet (UV) light has still a limited scope in optical microscopy despite its potential advantages over visible terms of resolution and interaction with wide variety biological molecules. The main challenge is to control robust, compact cost-effective way UV beams at the level single spatial mode concomitantly minimize propagation loss. To tackle this challenge, we present here photonic integrated circuits made aluminum oxide thin layers that are compatible both high-volume...
Abstract In the last decade, substantial research in field of post‐plasma grafting surface modification has focussed on introduction carboxylic acids surfaces by acrylic acid (AAc). present work, we report an alternative approach for biomaterial functionalisation. Thin poly‐ ε ‐caprolactone (PCL) films were subjected to a dielectric barrier discharge Ar‐plasma followed 2‐aminoethyl methacrylate (AEMA) under UV‐irradiation. X‐ray photoelectron spectroscopy (XPS) confirmed presence nitrogen....
Various types of nanofibers are increasingly used in tissue engineering, mainly for their ability to mimic the architecture at nanoscale. We evaluated adhesion, growth, viability, and differentiation human osteoblast-like MG 63 cells on polylactide (PLA) prepared by needle-less electrospinning loaded with 5 or 15 wt % hydroxyapatite (HA) nanoparticles. On day 7 after seeding, cell number was highest samples HA. This result confirmed XTT test, especially dynamic cultivation, when...
A novel 3D elemental and morphological analysis approach is presented combining X-ray computed tomography (μCT), fluorescence (XRF) tomography, confocal XRF in a single laboratory instrument (Herakles). Each end station of Herakles (μCT, XRF-CT, XRF) represents the state-of-the-art currently available techniques. The integration these techniques enables linking (quantitative) spatial distribution chemical elements within investigated materials to their three-dimensional (3D) internal...
The suitability of hydrogel biomaterials for bone regeneration can be improved by incorporation an inorganic phase in particle form, thus maintaining injectability. In this study, carbonate microparticles containing different amounts calcium (Ca) and magnesium (Mg) were added to solutions the anionic polysaccharide gellan gum (GG) crosslink GG release Ca2+ Mg2+ from thereby induce formation hydrogel–microparticle composites. It was hypothesized that increasing Mg content would promote...
Mineralization of hydrogel biomaterials is considered desirable to improve their suitability as materials for bone regeneration. Calcium carbonate (CaCO3) has been successfully applied a regeneration material, but hydrogel-CaCO3 composites have received less attention. Magnesium (Mg) used component calcium phosphate stimulate bone-forming cell adhesion and proliferation in vivo, its effect carbonate-based remains uninvestigated. In the present study, gellan gum (GG) hydrogels were...
Long-term packaging of miniaturized, flexible implantable medical devices is essential for the next generation devices. Polymer materials that are biocompatible and have attracted extensive interest devices, however realizing these with long-term hermeticity up to several years remains a great challenge. Here, polyimide (PI) based hermetic encapsulation was greatly improved by atomic layer deposition (ALD) nanoscale-thin, sandwich stack HfO2/Al2O3/HfO2 (ALD-3) between two layers. A thin...
Abstract In vascular tissue engineering, great attention is paid to the immobilization of biomolecules onto synthetic grafts increase bio‐ and hemocompatibility—two critical milestones in field. The surface modification field poly(ethylene terephthalate) (PET), a well‐known vascular‐graft material, matured oversaturated. Nevertheless, most developed methods are laborious multistep procedures generally accompanied by coating instability or toxicity issues. Herein, straightforward procedure...
Porous biodegradable scaffolds represent promising candidates for tissue-engineering applications because of their capability to be preseeded with cells. We report an uncrosslinked chitosan scaffold designed the aim inducing and supporting enzyme-mediated formation apatite minerals in absence osteogenic growth factors. To realize this, natural enzyme alkaline phosphatase (ALP) was incorporated into scaffolds. The makes available amine alcohol functionalities enhance biomineralization...
Acrylate-based photo-cross-linked poly(ε-caprolactone) (PCL) tends to show low elongation and strength. Incorporation of osteo-inductive hydroxyapatite (HAp) further enhances this effect, which limits its applicability in bone tissue engineering. To overcome this, the thiol–ene click reaction is introduced for first time order photo-cross-link PCL composites with 0, 10, 20, 30 wt % HAp nanoparticles. It demonstrated that at break ultimate strength increase 10- 2-fold, respectively, when...
Abstract Electrochemical impedance spectroscopy (EIS) has been established as an effective technique for bacterial biofilm detection. Through the need miniaturization, application of novel electrode materials gains interest. In this study, we introduce Sputtered IRidium Oxide Film (SIROF) electrodes varying sizes and geometries sensors Pre-emptive cyclic voltammetry (pre-cycling) was used to transform as-sputtered anhydrous iridium oxide films into hydroxides, reducing allowing material be...
This study presents a novel approach to manufacture rigid printed circuit board (PCB) using sustainable polymers. Current PCBs use fossil-fuel-based substrate, like FR4. recycling challenges due its composite nature. Replacing the substrate with an environmentally friendly alternative leads reduction in negative impacts. Polylactic acid (PLA) and Polyhydroxybutyrate (PHB) biopolymers are used this study. These two have low melting points (130–180 °C, 170–180 respectively) cannot withstand...