A5053994497- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Genital Health and Disease
- Global Cancer Incidence and Screening
- Reproductive tract infections research
- Ovarian cancer diagnosis and treatment
- Urological Disorders and Treatments
- Hepatitis B Virus Studies
- Molecular Biology Techniques and Applications
- Urinary and Genital Oncology Studies
- AI in cancer detection
- Herpesvirus Infections and Treatments
- Head and Neck Cancer Studies
- Breast Cancer Treatment Studies
- Neurobiology of Language and Bilingualism
- Civil and Structural Engineering Research
- Peripheral Nerve Disorders
- Medical Imaging and Analysis
- Polyomavirus and related diseases
- Female Genital Mutilation/Cutting Issues
- Geotechnical Engineering and Analysis
- Colorectal Cancer Screening and Detection
- Rabies epidemiology and control
- Advanced Neuroimaging Techniques and Applications
- Shoulder and Clavicle Injuries
Kaiser Permanente Fontana Medical Center
2011-2023
Cleveland Clinic
2002-2019
Peking University Shenzhen Hospital
2016
Kaiser Permanente
1999-2016
Cleveland Clinic Lerner College of Medicine
2016
Glenfield Hospital
2010
University Hospitals of Leicester NHS Trust
2010
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2009
In-Q-Tel
2009
Weatherford College
2007
The objectives of this study were to compare the sensitivity colposcopically directed biopsy (biopsy cervical quadrants with colposcopic impressions human papillomavirus, intraepithelial neoplasia [CIN], or cancer) for CIN 3 cancer (CIN 3+) among physicians and estimate increase in yield 3+ per colposcopy associated "random" biopsies and/or endocervical curettage (ECC).Two studies which 7 performed 1,383 examinations on women abnormal cytology reviewed. At colposcopy, cervix was divided into...
Abstract Self‐collected vaginal specimens tested for high‐risk human papillomavirus (HR‐HPV) have been shown to be less sensitive the detection of cervical intraepithelial neoplasia or cancer (≥CIN 3) than physician‐collected endocervical specimens. To increase sensitivity self‐collected specimens, we studied a self‐sampling device designed obtain larger specimen from upper vagina (POI/NIH self‐sampler) and more polymerase chain reaction (PCR)‐based HR‐HPV assay. Women (10,000) were screened...
The objective of this study was to compare the sensitivity and specificity a new method for self-sampling high risk human papillomavirus (HPV) with direct sampling liquid based cervical cytology. In Shanxi Province, China, 8,497 women (ages 27-56) underwent self-sample HPV using conical-shaped brush placed into upper vagina rotated. Three sixteen months later were screened liquid-based cytology tests. Subjects any abnormal test colposcopy multiple biopsies. Mean age 40.9 years. 4.4 percent...
Abstract To determine why a vaginal self‐collection tested for high‐risk human papillomavirus (HR‐HPV) by Hybrid Capture 2® (hc2) has lower sensitivity and specificity cervical intraepithelial neoplasia Grade 2 or worse (≥CIN 2), we collected 5 specimens (endocervix, upper vagina, perineum, self‐collection) from 2,625 women. Endocervical self‐collected had HR‐HPV tests hc2. All anogenital were 37 HPV genotypes [Linear Array®, (LA)] 397 women hc2 positive in endocervical randomly selected 71...
Abstract As acetic acid‐aided visual inspection (VIA) and colposcopic‐directed biopsy miss small ≥cervical intraepithelial neoplasia (CIN) 2, inflation of sensitivity VIA may occur when is the gold standard for ≥CIN 2. To determine whether such occurs, we reviewed 375 women with 2 from Shanxi Province Cervical Cancer Screening Study II. These had positive self or physician‐collected tests high‐risk human papillomavirus abnormal cervical cytology followed by colposcopy directed endocervical...
Our objective was to directly compare the accuracy of high-risk human papillomavirus (HPV) assays, Hybrid Capture 2 (hc2; Qiagen, Gaithersburg, MD) and Cervista (Hologic, Bedford, MA), in diagnosing cervical intraepithelial neoplasia (CIN) 3 or worse (cancer). A population-based, cross-sectional study (The Shenzhen Cervical Cancer Screening Trial II) conducted Guangdong Province China. Three HPV self direct sampling cytology, were studied. Abnormal results on any 6 tests (33%) resulted...
The study aimed to determine the increase in yield of cervical intraepithelial neoplasia 3 (CIN 3) or cancer 3+) from random biopsy quadrants without visible lesions and endocervical curettage (ECC) a low-prevalence setting.Random ECC (unless pregnant) have been obtained colposcopy clinic Southern California Permanente Medical Group (SCPMG)-Fontana since 2004. We reviewed experience SCPMG-Fontana for January 1, 2007, December 31, 2009, method diagnosis CIN 3+.Between 4677 women with median...
The aim of the study was to evaluate human papillomavirus (HPV) viral load combined with cytology as a secondary screening strategy after primary HPV screening.The data referring direct Hybrid Capture 2 (HC2), cytology, and histology from Shenzhen Cervical Cancer Screening Trial II were re-analyzed determine correlation between cervical lesions. In addition, algorithms using different loads cut points for immediate colposcopy plus triage compared several recommended or controversial...
The objective of this study was to compare the sensitivity and specificity a new method for self-sampling high risk human papillomavirus (HPV) with direct sampling liquid based cervical cytology. In Shanxi Province, China, 8,497 women (ages 27–56) underwent self-sample HPV using conical-shaped brush placed into upper vagina rotated. Three sixteen months later were screened liquid-based cytology tests. Subjects any abnormal test colposcopy multiple biopsies. Mean age 40.9 years. 4.4 percent...
To determine whether the sensitivity of screening tests that miss small cervical intraepithelial neoplasia (CIN) 2 or worse (e.g., acetic acid-aided visual inspection) is inflated when criterion standard (colposcopic-directed biopsy) misses same CIN worse.One thousand nine hundred twenty-eight women were screened using inspection, self-tests, and direct for high-risk human papillomavirus, liquid-based cytologic screening. All underwent colposcopy with biopsy. If a quadrant had no lesion,...
Long-term follow-up evaluations of cervical screening approaches are limited in low-resource areas. This prospective study assessed the risk future intraepithelial neoplasia grade 2 or worse (CIN2+) associated with baseline human papillomavirus (HPV) and cytologic status. In rural China, 1,997 women were screened 6 tests, including colposcopic evaluations, underwent biopsies 1999. December 2005, 1,612 1 less at rescreened by visual inspection, liquid-based cytology, HPV-DNA testing. All...
For cervical cancer screening to be feasible in developing countries, it must accurate, inexpensive, and easy administer. We conducted a pilot study rural Shanxi Province, People's Republic of China, determine disease prevalence feasibility preparation for large-scale comparative trial 6 tests. One-hundred thirty-six nonpregnant women with no history hysterectomy, pelvic radiation, or Papanicolaou tests were screened clinic. Ten percent the enrolled reported abnormal vaginal bleeding 45%...
We report a prevalence rate of 23.6% human papillomavirus (HPV) infection with oncogenic subtypes and 2.4% cervical intraepithelial neoplasia (CIN) III cancer (CC) in rural middle-aged women 2 counties the highest CC mortality Shanxi Province, China. examined association risk factors to HPV CIN 8,798 unscreened aged 35-50 years. Multivariate odds ratios (OR) 95% confidence intervals (CI) for each endpoint were obtained after adjustment covariates. The OR were: 1.41 (95% CI = 1.25-1.60) 1.42...
Cleveland Clinic Lerner College of Medicine Women's Health Institute Cleveland, OH Department OB/Gyn Kaiser Permanente Fontana, CA The authors received no financial support for this commentary. have declared they conflicts interest.
In Brief OBJECTIVE To estimate the sensitivity and specificity of visual inspection using acetic acid as a primary screen for cervical intraepithelial neoplasia (CIN). METHODS Visual was done on 1997 women aged 35–45 years in screening trial rural China. Each had colposcopy at least five biopsies (directed biopsy lesions, one 2, 4, 8, or 10 o'clock squamocolumnar junction each normal quadrant, an endocervical curettage). RESULTS Forty-three biopsy-proven CIN II, 31 III, 12 invasive cancer....
To confirm the accuracy of ThinPrep Pap Test (Cytyc Corp., Boxborough, Massachusetts, U.S.A.) on basis histologic diagnosis by biopsy and detection human papillomavirus (HPV) DNA in mass screening.A total 1,997 women residing Xiangyuan County, Shanxi Province, P.R.C., an area with a high incidence cervical carcinoma, were enrolled this study. We collected exfoliative samples from all subjects into liquid buffer (Preserv-Cyt [Cytyc]) utilized for both cytologic screening using HPV testing....
The aim of the study was to determine whether p16 positive/cervical intraepithelial neoplasia (CIN) 2, 3, and cancer (p16 + CIN 2/3+) detected by colposcopy-directed or random biopsy differ age, referral cytology, human papillomavirus (HPV) 16, lesion size.Data from Shenzhen Cervical Cancer Screening Trial II where, at colposcopy, women who had directed cervical biopsies were reviewed find with cancer; 227 such identified their paraffin-embedded tissue blocks recut, reviewed, then immune...
Although endocervical curettage (ECC) is often performed at colposcopy, it remains unclear whether should be done in all women, only women over a certain age, with unsatisfactory or normal colposcopic impressions. To clarify the indications for ECC, we determined proportion of colposcopies CIN 3, cancer (CIN 3+) detected by ECC showing 2, 2+).Review electronic medical records from colposcopy clinics.Between March 1, 1996, and April 23, 2013, approximately 18,537 cervical no missing results...