A5100335135- Cell Adhesion Molecules Research
- Alzheimer's disease research and treatments
- Rheumatoid Arthritis Research and Therapies
- Cholinesterase and Neurodegenerative Diseases
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Ubiquitin and proteasome pathways
- Tendon Structure and Treatment
- Dermatology and Skin Diseases
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Neurological Disease Mechanisms and Treatments
- Drug Transport and Resistance Mechanisms
- Aquaculture disease management and microbiota
- Reproductive Biology and Fertility
- Psoriasis: Treatment and Pathogenesis
- Foot and Ankle Surgery
- S100 Proteins and Annexins
- HER2/EGFR in Cancer Research
- Protein Kinase Regulation and GTPase Signaling
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Genomics, phytochemicals, and oxidative stress
Hangzhou Medical College
2023-2025
Tongren Hospital
2025
Shanghai Jiao Tong University
2025
Central China Normal University
2013-2025
Central South University
2013-2024
Second Xiangya Hospital of Central South University
2014-2024
Xiangyang Central Hospital
2024
South China Agricultural University
2023
Chongqing Medical University
2023
Hunan Provincial Maternal and Child Health Hospital
2023
The study explored the knowledge, attitude, and practice (KAP) toward severe craniocerebral trauma perioperative management among anesthetists in China. This cross-sectional recruited from 15 provinces China between October 17, 2022, November 09, 2022. Pearson's correlation was used to assess relationships KAP dimension scores, multivariable linear regression performed identify factors associated with higher scores. included 200 (122 females). mean scores were 50.41±7.36 (possible range,...
Arsenic trioxide (ATO, As2 O3 ) is currently used to treat acute promyelocytic leukemia. However, expanding its use include high-dose treatment of other cancers severely hampered by serious side effects on healthy organs. To address these limitations, we loaded ATO onto folate (FA)-labeled human serum albumin (HSA) pretreated with glutathione (GSH) based the low pH- and GSH-sensitive arsenic-sulfur bond, termed resulting smart nanodrug as FA-HSA-ATO. FA-HSA-ATO could specifically recognize...
Collagen-based hydrogels have a significant impact on wound healing, but they suffer from structural instability and bacterial invasion in infected wounds. Here, electrospun nanofibers of esterified hyaluronan (HA-Bn/T) are developed to immobilize the hydrophobic antibacterial drug tetracycline by π-π stacking interaction. Dopamine-modified HA-Bn/T employed simultaneously stabilize structure collagen-based hydrogel chemically interweaving collagen fibril network decreasing rate degradation....
A novel, p125<sup>FAK</sup> homologue, CADTK, has been detected in neural, epithelial, or hematopoietic cells but not fibroblasts. We now demonstrate CADTK expression a mesenchymal cell, rat aortic smooth muscle (RSMC). Angiotensin II (Ang II) platelet-derived growth factor (PDGF-BB and PDGF-AA) markedly stimulated tyrosine phosphorylation RSMC did affect phosphorylation. The PDGF-dependent was slower more prolonged than that of Ang II, correlating well with the differential effects these...
Monosodium urate (MSU) crystals-induced inflammation is a key initiator in gouty arthritis. Curcumin an active ingredient possessing anti-inflammatory efficacy. But the underlying mechanism not fully understood and its effect on arthritis remains elusive.We evaluated effects of curcumin cell viability primary rat abdominal macrophages with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT). Then supernatants MSU crystals-stimulated cells were collected subjected to...
The deubiquitinase USP7 has been identified as an oncogene with key roles in tumorigenesis and therapeutic resistance for a series of cancer types. Recently small molecular inhibitors have developed to target USP7. However, the anticancer mechanism is still elusive.Cell viability or clonogenicity was tested by violet crystal assay. Cell apoptosis cell cycle analyzed flow cytometry, chromosome misalignment observed fluorescent microscopy. protein interaction PLK1 detected tandem affinity...
The calcium-dependent tyrosine kinase (CADTK), also known as Pyk2/RAFTK/CAKβ/FAK2, is a cytoskeleton-associated kinase. We compared CADTK regulation with that of the highly homologous focal adhesion (FAK). First, we generated site-specific mutants. Mutation Tyr402 eliminated autophosphorylation and significantly decreased activity. Tyr881, putative Src phosphorylation site predicted to bind Grb2, had little effect on regulation. family kinases resulted in even when co-expressed Tyr402/Tyr881...
BackgroundFollicular stimulating hormone (FSH) is a glycoprotein and widely used for the treatment of infertility; FSH action mediated by receptor (FSHR), SNPs which determine ovarian response. Two polymorphisms FSHR gene were identified, caused change threonine (T) to alanine (A) at position 307 asparagine (N) serine(S) 680. Both polymorphic sites give rise three discrete variants FSHR: TT, TA, AA 307; NN, NS, SS Methodology/Principal Findings450 Chinese women recruited in an assisted...
Citrullinated neoepitopes have emerged as key triggers of autoantibodies anti-citrullinated protein antibodies (ACPA) synthesis in rheumatoid arthritis (RA) patients. Apart from their critical role homeostasis and thrombosis, platelets a significant contribution to inflammation well. Although anuclear nature, an intricate post-translational modification machinery. Till now, citrullination its trigger ACPA production RA is unexplored research direction. Herein, we investigated the expression...
Alzheimer's disease (AD) stands as the predominant age-related neurodegenerative disorder, for which efficacious treatment remains elusive. An auspicious avenue this lies in natural compounds sourced from tranditional medicine and plant origins. Parthenolide (PTN) is a product with multiple biological functionsand. Recent investigations have illuminated PTN's protective properties against neurological maladies; however, its potential therapeutic role AD uncharted. This study aims to explore...
Freshly isolated human monocytes do not express p125(FAK) but upon adherence to substrata activate the highly related calcium-dependent tyrosine kinase (CADTK), also known as Pyk2, CAKbeta, RAFTK, and FAK2. The monocyte CADTK was 5 kDa smaller than protein from epithelial cells; isolation sequencing of cDNA revealed a predicted 42-amino acid deletion between two proline-rich domains enzyme. nucleic sequence suggests that is caused by alternative RNA splicing. This species found in T B...
The aim of the present study was to investigate association inflammatory cytokines and matrix metalloproteinase-9 (MMP-9) with cerebral arteriovenous malformation (AVM) hemorrhage. A total 31 AVM patients were divided into groups according specimen sources; a ruptured group 14 an unruptured 17 patients. control comprised 30 epilepsy who underwent temporal lobectomy. Peripheral blood obtained from all preoperatively. Tissue samples removed nidus during surgery or lobes undergoing surgical...
Carbamylated proteins and dysregulated neutrophils are implicated in rheumatoid arthritis (RA) pathogenesis. Herein, we characterized the present RA synovial fluid (SF) using proteomic techniques evaluated their contribution to protein carbamylation. RA-SF neutrophil profile SF proteome signature were investigated high-resolution mass spectrometry. degree of carbamylation by spectrometric analysis. ELISA chemiluminescence kits used examine myeloperoxidase (MPO) activity, hydrogen peroxide...
Camellia chrysantha (Hu) Tuyama (CCT), an ornamental plant possessing antioxidant activity, has been infused as tea and drank for its health benefits. The components in CCT, however, had not clearly characterized. To quickly identify the constituents of a composition-activity relationship strategy based on ultra high-pressure liquid chromatography coupled with linear ion trap hybrid orbitrap mass spectrometry orthogonal partial least-squares method applied. As result, 16 variables were found...
Psoriasis is an autoimmune and inflammatory disease, which estimated to affect 2-3% of the population in world. PSORI-CM02 empirical formula Chinese medicine optimized from Yin Xie Ling, widely used treat psoriasis China for decades. However, its antipsoriatic mechanisms are still not well understood. Here, we explored therapeutic effects on action imiquimod-induced psoriasis-like mouse models human HaCaT cells. In experiments vitro, significantly inhibited cell proliferation dose-dependent...
Background Gestational diabetes mellitus (GDM) is a common complication during pregnancy that poses serious health risks to both mothers and their offspring. Risk factors for GDM, such as obesity, have been extensively reported. However, the association between body composition GDM risk remains unclear. Therefore, we conducted retrospective cohort study investigate relationship in early of developing GDM. Methods A total 3,159 pregnant women were enrolled June 2020 December 2021, with 280...
Freshly isolated peripheral blood monocytes lack focal adhesion kinase (p125(FAK)) but activate a second member of this family, calcium-dependent tyrosine (CADTK; also known as Pyk2/CAKbeta/RAFTK/FAK2), upon or stimulation with chemokines. To study the role CADTK in monocyte adherence and motility, we performed immunocytochemical localization that showed at leading edge ruffling lamellipodial structures freshly isolated, adhered human monocytes. We next introduced CADTK/CAKbeta-related...
BACKGROUND This study aimed to investigate the effects of recombinant human brain natriuretic peptide (rhBNP) on IL-6, TNF-α, and IL-10 secretion in LPS-activated RAW 264.7 cells peripheral blood mononuclear (PBMCs) vitro explore related signaling pathways regulation mechanisms BNP systemic inflammatory response syndrome (SIRS). MATERIAL AND METHODS MTT assay was used evaluate rhBNP cell viabilities. Lipopolysaccharide (LPS) induce inflammation response. The whole divided into 8 groups:...