A5101735633- Enzyme-mediated dye degradation
- Microbial Metabolism and Applications
- Carbohydrate Chemistry and Synthesis
- Catalytic C–H Functionalization Methods
- Fungal Biology and Applications
- Biochemical and biochemical processes
- Glycosylation and Glycoproteins Research
- Radical Photochemical Reactions
- Natural product bioactivities and synthesis
- Electrochemical sensors and biosensors
- Sulfur-Based Synthesis Techniques
- Enzyme Catalysis and Immobilization
- Phytochemistry and Biological Activities
- Microbial Metabolites in Food Biotechnology
- Biocrusts and Microbial Ecology
- Asymmetric Hydrogenation and Catalysis
- Polyamine Metabolism and Applications
- melanin and skin pigmentation
- Analytical chemistry methods development
- Microbial bioremediation and biosurfactants
- bioluminescence and chemiluminescence research
- Pesticide and Herbicide Environmental Studies
- Chemical Synthesis and Analysis
- Synthesis and Properties of Aromatic Compounds
- Photochromic and Fluorescence Chemistry
National Research Tomsk State University
2016-2025
Tomsk Polytechnic University
2016-2025
KTH Royal Institute of Technology
2022-2025
N.D. Zelinsky Institute of Organic Chemistry
2017-2022
Pennsylvania State University
2020
New York University
2020
University of California, Riverside
2020
Tsinghua University
2020
Institute of Physics and Technology
2020
Moscow Power Engineering Institute
2020
A protocol for stereoselective C-radical addition to a chiral glyoxylate-derived <italic>N</italic>-sulfinyl imine was developed through visible light-promoted photoredox catalysis, providing convenient method the synthesis of unnatural α-amino acids.
Herein, we report a silver-catalyzed protocol for decarboxylative cross-coupling between carboxylic acids and isocyanides, leading to linear amide products through free-radical mechanism. The disclosed approach provides general entry variety of decorated amides, accommodating diverse array radical precursors, including aryl, heteroaryl, alkynyl, alkenyl, alkyl acids. Notably, the proved be efficient late-stage functionalization several elaborate pharmaceuticals, demonstrating its potential...
A practical protocol for the stereoselective synthesis of unnatural α-amino acids is disclosed, using ubiquitous aliphatic alcohols as radical precursors to form acid backbone under redox-neutral photoredox-mediated conditions.
This paper describes the structural analysis of native form laccase from Trametes hirsuta at 1.8 Å resolution. structure provides a basis for elucidation mechanism catalytic action these ubiquitous proteins. The resolution provided good level detail compared with many previously reported structures. A brief comparison active sites other laccases is given.
Abstract Phase transfer catalysis (PTC) is widely used for the preparation of anomerically pure aryl glycosides by glycosylation phenols with glycosyl halides. Here, we attempted to synthesize 4‐(3‐chloropropoxy)phenyl (CPP) sialoside – a useful Janus glycoside neoglycoconjugate synthesis. A batch reaction under typical PTC conditions ( N ‐acetylsialyl chloride, 4‐(3‐chloropropoxy)phenol, Bu 4 NHSO , AcOEt, 10 % aq Na 2 CO 3 ) resulted in formation CPP as single anomer, albeit low yield....
Non‐typical C‐functionalized sugars represent a prominent yet hardly accessible class of biologically‐active compounds. The available synthetic methodologies towards such sugar derivatives suffer either from an extensive use protecting groups, requiring long and laborious manipulations, or limited predictability non‐controllable site‐selectivity the employed C‐functionalization reactions. In this work, we disclose alternative methodology non‐typical that allows facile, site‐selective,...
Non‐typical C‐functionalized sugars represent a prominent yet hardly accessible class of biologically‐active compounds. The available synthetic methodologies towards such sugar derivatives suffer either from an extensive use protecting groups, requiring long and laborious manipulations, or limited predictability non‐controllable site‐selectivity the employed C‐functionalization reactions. In this work, we disclose alternative methodology non‐typical that allows facile, site‐selective,...
Abstract Aromatic compounds serve as key feedstocks in the chemical industry, typically undergoing functionalization or full reduction. However, partial reduction via dearomative sequences remains underexplored despite its potential to rapidly generate complex three-dimensional scaffolds and existing strategies often require metal-mediated multistep processes suffer from limited applicability. Herein, a photocatalytic radical cascade approach enabling difunctionalization through selective...
A novel glycosyl donor with a triisopropylsilyl (TIPS) nonparticipating group at O-2 is introduced for use in 1,2-cis-galactosylation. Coupling the 2-O-TIPS-substituted thiogalactoside series of mono- and disaccharide acceptors was found to lead exclusively α-linked oligosaccharides. The observed exceptionally high α-selectivity interpreted terms conformational changes cation induced by bulky 2-O-TIPS group.
Abstract Formation of 1,2‐ trans ‐arabinofuranoside linkage in arabinans from Mycobacterium tuberculosis using differently protected Ara‐β‐(1→2)‐Ara disaccharide glycosyl donors the absence a participating group at O‐2 was studied. The influence nature protective and leaving groups on efficiency stereoselectivity ‐arabinofuranosylation investigated. p ‐tolyl thioglycoside containing five triisopropylsilyl ‐stereoselective synthesis tetrasaccharide corresponding to fragment M. arabinan shown...
Herein, a straightforward synthetic approach for the construction of phenanthridin-6(5H)-one skeletons is disclosed. The developed protocol relies on palladium catalysis, providing controlled access to range functionalized phenanthridin-6(5H)-ones in 59-88% yields. Furthermore, plausible reaction pathways are proposed based mechanistic experiments.
Laccases are members of the blue multi-copper oxidase family that oxidize substrate molecules by accepting electrons at a mononuclear copper centre and transferring them to trinuclear centre. Dioxygen binds and, following transfer four electrons, is reduced two water. Crystals laccase from Cerrena maxima have been obtained X-ray data were collected 1.9 Å resolution using synchrotron radiation. A preliminary analysis shows enzyme has typical structure several carbohydrate sites identified....
The outcome of the nucleophilic opening 3-O-benzoyl-β-d-arabinofuranose 1,2,5-orthobenzoate with 4-(ω-chloroalkoxy)phenols (SnCl4, CH2Cl2, –25 °C) unusually strongly depends on length methylene chain nucleophile. presence one extra group in molecule 4-(3-chloropropoxy)phenol [as compared to 4-(2-chloroetoxy)phenol] results four-fold reduction reaction time and five-fold increase yield a selectively protected monosaccharide glycoside hydroxy at C-5, which is valuable building block for...