A5033795844- Gut microbiota and health
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Sirtuins and Resveratrol in Medicine
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Microbial Metabolism and Applications
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Reproductive Physiology in Livestock
- Tryptophan and brain disorders
- Dietary Effects on Health
- Immune Response and Inflammation
- Cancer Research and Treatments
- IL-33, ST2, and ILC Pathways
Technical University of Denmark
2023-2025
Novo Nordisk Foundation
2024-2025
University of Copenhagen
2018-2024
The objectives were 1) to characterize a Göttingen Minipig model of metabolic syndrome regarding its colon microbiota and circulating microbial products, 2) assess whether ovariectomized female castrated male minipigs show similar phenotypes. Twenty-four nine-week-old Minipigs allocated four groups based on sex diet: females males fed either chow or high-fat diet (HFD) for 12 weeks. At study end, body composition plasma biomarkers measured, mixed meal tolerance test (MMT) an intravenous...
Abstract The gut microbiome has emerged as a key player in modulating immune responses against cancer, suggesting that microbial interventions can enhance treatment outcomes. Indole metabolites produced by probiotic bacteria activate the aryl hydrocarbon receptor (AhR), transcription factor important for cell regulation. Cancer patients with high plasma concentrations of these have shown improved survival. Building on findings, we engineered Escherichia coli Nissle 1917 to produce AhR...
The aim of this study was to examine the effect exercise training and dietary supplementation resveratrol on composition gut microbiota test hypothesis that can prevent high-fat diet (HFD)-induced changes in microbiota. Mice fed a HFD supplemented with (4 g/kg food) were protected against diet-induced obesity, while trained HFD-fed animals (running average 50 km/week) not. Dietary induced predominantly low-abundant bacteria, high-abundant bacteria as analyzed by ADONIS Weighted UniFrac...
Gut bacteria are known to produce bacteriocins inhibit the growth of other bacteria. Consequently, have attracted increased attention as potential microbiome-editing tools. In this study we examine inhibitory spectrum 75 class II against 48 representative gut microbiota species. The were heterologously expressed in Escherichia coli and evaluated vitro, ex vivo vivo. vitro assays revealed 22 at least one species showed selective inhibition patterns implicated certain disorders diseases. Three...
Abstract Background Gut microbiota dysbiosis is associated with the development of non-alcoholic steatohepatitis (NASH) through modulation gut barrier, inflammation, lipid metabolism, bile acid signaling and short-chain fatty production. The aim this study was to describe impact a choline-deficient amino defined high fat diet (CDAHFD) on in male Göttingen Minipig model selected pathways implicated NASH. Results Eight weeks CDAHFD resulted significantly altered colon mainly driven by...
Low-fat diets and exercise are generally assumed to ameliorate obesity-related metabolic dysfunctions, but the importance of vs. dietary changes is debated. Male C57BL/6J mice were fed a high-fat/high-sucrose (HF/HS) diet induce obesity then either maintained on HF/HS or shifted low-fat (LF) containing salmon entrecote. For each diet, half animals exercised voluntarily for 8 weeks. We determined body composition, glucose tolerance, insulin sensitivity hepatic triacylglycerol levels. The...
Some oligosaccharides induce growth of anti-inflammatory bacterial species and regulatory immunity in humans as well animals. We have shown that the equine gut microbiota immune-microbial homeostasis largely stabilize within first 50 days life. Furthermore, we previously established certain correlated with immunity. Accordingly, hypothesized an oligosaccharide rich diet fed to foals during would increase abundance associated immunity, this influence immune responses foals. Eight pregnant...
Abstract Background : Bacteriocins are antimicrobial peptides with properties making them applicable for food preservation and pathogen control. However, their impact on the gut microbiota remains understudied. In this study we sought to examine inhibitory spectrum of 75 class II bacteriocins against 49 representative species human including 21 Biosafety level 2 organisms. The were cloned expressed in Escherichia coli evaluated vitro, ex vivo vivo. Results vitro spot assays using BL21-AI...