- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Neurological Disorders and Treatments
- Facial Trauma and Fracture Management
- Traumatic Ocular and Foreign Body Injuries
- Intraocular Surgery and Lenses
- Cerebral Venous Sinus Thrombosis
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Impairment Studies
- Ocular Oncology and Treatments
- Neuroscience and Neural Engineering
- Retinal and Macular Surgery
- Photoreceptor and optogenetics research
- Dental Radiography and Imaging
- Pituitary Gland Disorders and Treatments
- Medical and Biological Sciences
- Drug-Induced Ocular Toxicity
- Intraoperative Neuromonitoring and Anesthetic Effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
Czech Technical University in Prague
2013-2025
Palacký University Olomouc
2022-2024
Oblastní nemocnice Kladno
2024
Charles University
2014-2018
University of Hradec Králové
2017
Ophthalmology Clinic
2011-2012
Ocní klinika
1990-2010
Centro poliklinika
1997
A case report of a 70-year-old woman who had never suffered from any eye disease is presented. It was found that 2 weeks prior to the ophthalmological examination at another clinic 'something fell' into her right eye; she noticed decline in vision left eye. On ophthalmologic Visual Acuity, Right Eye (VARE) 0.4 and Left (VALE): fingers 1 m. Incipient cataracts both eyes, more on right. optic nerve (ON) evaluation, papilla cup-to-disk ratio (C/D) was=0.6 0.7, R/L, respectively. total month...
Objective: To verify whether there is a correlation between visual field changes in high-tension glaucoma and functional magnetic resonance of the cortex.Methods patients: The authors examined nine patients with different stages by (fMRI). measurements were carried out on Philips Achieva 3T TX MR system using BOLD method. Optical stimulation was provided black white checkerboard alternated its negative image frequency 2 Hz. Each measurement consisted sequence five 30-second active phase...
The objective of our work was to determine whether there is a difference in fMRI activation between patients with high tension glaucoma (HTG) and those normal (NTG).The sample consisted eight different stages (3 females aged 41-65 5 males 40-73 years) patients, also (6 53-70 2 40-52 years). control group healthy subjects 23-46 23-65 All underwent complete ophthalmological examination, including visual field, colour vision, electrophysiological functions. results were compared images after...
The present study aimed to determine how the vascular density (VD) in each segment peripapillary influences retinal nerve fiber layer (RNFL) and eliminate its contribution RNFL pathological intraocular pressure (IOP). In a cohort of 69 subjects (mean age, 45±6 years old) with untreated ocular hypertension (122 eyes total) enrolled this study, Ocular Response Analyser IOP was measured during routine outpatient care. Its value >21 (range, 21-36) mmHg all eyes. Furthermore, VD were using...
The study is designed to determine the relationship between progress of wet form age-related macular degeneration and activity visual cortex examined using functional magnetic resonance imaging. Ten patients with (9 female 1 male) a mean age 74.7 years (58-85 years) at various stages bilateral involvement disease were included. Patients did not suffer from any other ocular nor neurological disease. All underwent imaging examinations stimulation both eyes black-and-white checkerboard size...
The aim of the present study was to investigate relationship between intraocular pressure (IOP), vessel density (VD), retinal nerve fiber layer (RNFL) parameters and overall defect (OD) visual field in eyes where antiglaucoma treatment had not yet been initiated. A total 61 subjects (122 eyes) who an IOP >20 mmHg on several occasions, at least one eye, routine outpatient care were included. These never treated for hypertension glaucoma. cohort divided into four subgroups. In first group,...
Purpose. The aim of this study was to define the thickness retinal nerve fiber layer (RNFL) in peripapillary region retina after adjusting for effect vessel density (VD) patients with pathological intraocular pressure (IOP). Patients and Methods. 69 (122 eyes) IOP >21 mmHg (range 21-36 mmHg, mean 23.65±2.70 mmHg). 32 were men (average age 55±13 years) 37 women 52±14 years). measured using Ocular Response Analyser (ORA). VD RNFL by OCT (Avanti RTVue XR) eight segments: Inferior Temporal - IT...
The aim of the study was to analyse different clinical pictures in patients with progressive cone dystrophy (PCD), compare these results optical coherence tomography (OCT) and evaluate benefits this method for diagnosis.The group consisted 16 (32 eyes) PCD. All were examined visual acuity, colour sense field. We performed biomicroscopic examination, photo-documentation, fluorescein angiography, electrophysiological tests OCT.Using biomicroscopy we found changes retinal pigment epithelium...
The aim of this study was to assess retinal toxicity in a rabbit model after carboplatin delivered as repeated transcorneal intravitreal injection, order determine the highest possible safe dose for use human retinoblastoma "seeding" tumor chemotherapy.We used six albino rabbits an vivo experiment and injected 0.008 mg intravitreally (iv) 4 times at two-week intervals. 0.08 mL saline into left eye. We recorded electroretinograms (ERGs) before first injection fourth injection. Platinum...
Objectives: To verify whether there is dependence between corneal thickness and progression of glaucoma, to assess the impact early changes in visual field on their time. Methods Patients: Findings 132 eyes 67 patients with primary hypertensive open-angle 27 men 40 women, mean age 66 years (28 - 84 years) were evaluated, retrospectively. Two women included into set one eye (the other had acuity below 0.1). All compensated IOP after eventual correction 18 mm Hg. None been previously treated...
The aim of this study was to determine whether the values vessel density (VD) and perfusion parameters in ophthalmic artery (OA) central retinal (CRA) same eye differ patients with hypertensive glaucoma (HTG) from normotensive (NTG). first group consisted 20 HTG (40 eyes). Patients were verified have primary open-angle (POAG). second VD used Avanti RTVue XR Optovue (USA). Peak systolic velocity (PSV), end-diastolic (EDV) resistance index (RI) measured both using Doppler sonography on...
The present study demonstrates alterations of the contralateral side optic tract to an nerve traumatic lesion. Visual acuity right eye following Traumatic neuropathy (TON) remained at 0 injury. Electrophysiological examination using pattern electroretinogram revealed values reduced by 50% in compared with left eye. Pattern visual‑evoked potential evaluation indicated a bilateral lesion higher decrease stimulation. Magnetic resonance imaging atrophy. Functional magnetic decreased activity...
The study provides an up-to-date overview of pathogenesis, functional and structural changes in normal tension glaucoma (NTG) its differences from high glaucomas (HTG). authors point to less known facts which make both diagnostic groups different. First all, there are electrophysiological findings that verify pathology the complete visual pathway HTG contrast NTG where retinal ganglion cell response is relatively but abnormalities pathway. This corresponds magnetic resonance imaging brain...
Hypertensive glaucoma (HTG) causes damage to the retinal ganglion cells and eventually entire visual pathway due high intraocular pressure (IOP). However, increased IOP will also affect vessel density (VD) of posterior pole eye related nerve fibres (RNFL). In normotensive (NTG), are relatively intact. The pathology is at level fibres. unanswered question what has altered cell retina optic head in NTG?The aim this study was determine whether there a correlation between fibre layer (RNFL) same...
The otolaryngologist often meets with fractures of the orbital floor. most serious complication is diplopia, arising as a result herniation contents, or without fixation inferior rectus muscle. aim our work was to create mathematical model calculate volume prolapsed soft tissue orbit in blow-out fractures, factor deciding on need for surgical treatment.In retrospective study (2007-2013), we evaluated 80 patients divided into two equal groups: 40 conservatively treated and surgically...
The aim of the study was to evaluate progression changes in visual fields patients with hypertensive glaucoma (HTG) and normotensive (NTG) following administration prostaglandins beta blockers, as well also NTG without ophthalmological therapy. Methodos. HTG group included 12 (mean age 66 years) approximately same field central corneal thickness (CCT-568um) treated prostaglandins, 60 years, CCT=544um) beta-blockers. IOP ranged from 18mmHg for whole follow-up period. consisted three...
This article provides an updated overview of the structural and functional changes in normotensive glaucoma its variations from hypertensive glaucoma. The authors point out less familiar facts which both diagnostic groups differ.
Objective: To find whether changes in lateral geniculate nucleus (LGN) can be determined vivo hypertensive and normotensive glaucoma, these correlate with the advancement of glaucoma disease.Methods subjects: The authors examined two groups patients, 9 patients (HTG) different stages (NTG). diagnosis was based on a comprehensive ophthalmological examination. results both were compared group healthy subjects. A examination supplemented by visual field means fast threshold program. sum...
To determine intravitreal and plasma concentrations retinal toxicity after transcorneal injection of 1 μg 2 topotecan (Hycamtin).Twelve healthy albino rabbits were included in this vivo experiment. Six anesthetized received a single (group A) or B) topotecan. Vitreous blood samples collected until 168 h. Left eyes treated with the same volume saline. Plasma vitreous levels determined by high-performance liquid chromatography. Area under concentration time curve (AUC) was calculated using...
Aims: To investigate the dependence of blood vessel density and velocity in ophthalmic artery arteria centralis retinae same eye patients with normotensive glaucoma. Methods: The sample consisted 20 glaucoma (NTG). There were 17 women (mean age 56.1) 3 men 60 years). Inclusion criteria for study: visual acuity 1.0 correction up to ±3 dioptres, approximately equal changes field, whereby it was incipient NTG diagnosis confirmed by electrophysiological examination, without further ocular or...
The aim of this study was to evaluate the changes in IOL position (axial shift, tilt and decentration) capsular bag after Nd:YAG laser capsulotomy create a user-friendly software that is optimized for output available imaging technology, then verify relationship between biometric parameters eye extent position.The included 35 artephakic eyes underwent capsulotomy. Before at least one hour capsulotomy, all patients following assessments: optical biometry (Lenstar LS900), OCT with anterior...
Introduction: Functional and structural changes of the central nervous system corresponding to high tension glaucoma (HTG) normal (NTG) were studied. Methods: In four patient groups, 80 eyes in 40 patients examined. First group 30 had three types HTG: 10 with primary open angle (POAG), pigmentary (PG) monitored pseudoexfoliative (PEXG). The last consisted NTG. Comparison visual field, GDx, macular volume, PERG PVEP was performed control consisting 20 healthy subjects comparable age...
A case report of a 40-year-old patient with tuberculosis treated ethambutol is described. Within six months starting treatment, there was painless sudden decline in visual function. Despite the known complications it discontinued after another three months.In report, we highlight damage to dominantly peripheral pathways. Using electrophysiological examinations, showed significant alteration optic nerves. Optical Coherence Tomography (OCT) progressive loss vessel density and nerve fibre layer...
The aim of this study was to investigate whether the retinal nerve fibre layer (RNFL) in some segments optic disc pathological intraocular pressure is more damaged eyes without antiglaucoma treatment.The cohort consisted 69 subjects (122 eyes), 32 males (6x one, 26x both eyes) aged 21 76 years and 37 females (4x one 30x 22 75 years, who were measured have IOP greater than mmHg (21-36) routine ambulatory care. Measurements performed using Ocular Response Analyser, taking into account corneal...