A5027060123- Cervical Cancer and HPV Research
- Genital Health and Disease
- Estrogen and related hormone effects
- Optical Coherence Tomography Applications
- Endometrial and Cervical Cancer Treatments
- Thyroid and Parathyroid Surgery
- Photoacoustic and Ultrasonic Imaging
- Parathyroid Disorders and Treatments
- Ovarian cancer diagnosis and treatment
- Nail Diseases and Treatments
- Cancer-related gene regulation
- Gynecological conditions and treatments
- Reproductive tract infections research
- Global Cancer Incidence and Screening
- RNA Research and Splicing
- Hormonal Regulation and Hypertension
- Ubiquitin and proteasome pathways
- Chemotherapy-related skin toxicity
- Uterine Myomas and Treatments
- Histone Deacetylase Inhibitors Research
- Management of metastatic bone disease
- Cell Adhesion Molecules Research
- Hippo pathway signaling and YAP/TAZ
- Peptidase Inhibition and Analysis
- BRCA gene mutations in cancer
Universitätsmedizin Göttingen
2020-2025
Ludwig-Maximilians-Universität München
2013-2025
University of Göttingen
2020-2023
LMU Klinikum
2002-2020
Klinik für Frauenheilkunde
2009-2019
München Klinik
2009-2019
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
2017-2019
Deutsche Nationalbibliothek
2018
Robert Koch Institute
2018
Krebsregister Saarland
2018
In this study, we analyzed vitamin D receptor (VDR) expression and survival in a breast cancer patient cohort of 82 patients. Immunohistochemical analysis was possible 91.5% the patients (75/82). Staining evaluated using semi-quantitative assay according to Remmele Stegner (immunoreactivity score [IRS]). IRS 0–1 negative/very low, 2–4 moderate high, 6–12 high. Statistical performed by Spearman’s correlation test ( p<0.05 significant). Overall Kaplan-Meier estimations. Only 6 had negative...
The correct differentiation between unilateral and bilateral adrenal involvement in patients with primary aldosteronism (PA) is of utmost importance to justify surgical treatment. aim this study was determine the accuracy imaging compared venous sampling (AVS), histopathology postoperative outcome.The data all unequivocal AVS who underwent laparoscopic adrenalectomy for May 2004 April 2015 were entered retrospective study. We computed tomography (CT) magnetic resonance (MRI) results...
Injury to parathyroid glands during thyroid and surgery is common postoperative hypoparathyroidism represents a serious complication. Parathyroid possess unique autofluorescence in the near-infrared spectrum which could be used for their identification protection at an early stage of operation. In present study was visualized intraoperatively using standard Storz laparoscopic near-infrared/indocyanine green (NIR/ICG) imaging system with minor modifications xenon light source (filtered emit...
Abstract Background Basal-like breast cancer (BLBC) is one of the most aggressive malignant diseases in women with an increased metastatic behavior and poor prognosis compared to other molecular subtypes cancer. Resistance chemotherapy main cause treatment failure BLBC. Therefore, novel therapeutic strategies counteracting gain aggressiveness underlying therapy resistance are urgently needed. The epithelial-to-mesenchymal transition (EMT) has been established as central process stimulating...
Optical coherence tomography (OCT) permits high-resolution imaging of tissue subsurfaces up to 2 mm in depth. The purpose this study was evaluate the accuracy and reproducibility OCT characterization cervical intraepithelial neoplasia (CIN) distinguish between different CIN grades.Colposcopy-guided images were taken from unsuspicious suspicious areas women with suspected CIN. Each woman then underwent directed biopsies. All separately evaluated by two blinded investigators later compared...
Since BRCA1 associated breast cancers are frequently classified as hormone receptor negative or even triple negative, the application of endocrine therapies is rather limited in these patients. Like receptors that bind to estrogen progesterone, thyroid (TRs) members nuclear superfamily. TRs might be interesting biomarkers - especially absence classical receptors. The current study aimed investigate whether may specifically expressed cancer cases and they prognostic significance patients...
To investigate the feasibility of near-infrared autofluorescence (AF) and indocyanine green (ICG) fluorescence to identify parathyroid glands intraoperatively.Fluorescence imaging was carried out during open thyroid surgery. After visual identification, were exposed (NIR) light with a wavelength between 690 770 nm. The camera Storz® NIR/ICG endoscopic system used detects NIR as blue signal. Therefore, AF expected be displayed in color channel contrast surrounding tissue. Following imaging,...
A wide variety of answers can be found regarding the question whether G-protein-coupled estrogen receptor 1 (GPER1) is tumor supportive or suppressive. In cervical carcinoma (CC), function GPER1 poorly understood. this work, we aimed to clarify what role plays in CC, promoting suppressive.Transient silencing was conducted using RNAi and approved by RT-qPCR. Clonogenic potential tested colony sphere formation. Expression SERPINE1/PAI-1 quantified RT-qPCR Western blot. Morphological changes...
Abstract Background Breast cancer (BC) is the most frequent tumor entity in women worldwide with a high chance of therapeutic response early- and non-metastatic disease stages. Among all BC subtypes, triple-negative (TNBC) challenging subtype lacking effective molecular targets due to particular enrichment stem cells (CSCs), frequently leading chemoresistant phenotype metastasis. The Ubiquitin Specific Peptidase 22 (USP22) deubiquitinase that has been associated CSC-promoting function...
Abstract Objective Optical coherence tomography (OCT) is a non‐invasive high‐resolution imaging technique that permits characterization of microarchitectural features tissue up to 2 mm in depth real time. The purpose this study was evaluate the feasibility OCT for identification precancerous (cervical intraepithelial neoplasia (CIN)) and cancerous lesions uterine cervix. Methods We conducted prospective on use women with suspected CIN. images were obtained colposcopy from non‐suspicious...
Abstract Background and Objective The identification of parathyroid glands can be a major problem in surgery. purpose this study was to evaluate the feasibility optical coherence tomography (OCT) distinguishing between tissue, thyroid lymph nodes, adipose tissue. Methods Ex vivo OCT images as well histological sections were generated from glands, nodes fat order define significant morphologic differences these entities. As second step all separately evaluated by two blinded investigators...
Objective Non‐surgical therapies are needed to reduce the rate of progression low‐grade cervical intraepithelial neoplasia (CIN 1) high grade CIN 2/3). The aim this study was assess efficacy and safety hexaminolevulinate (HAL) photodynamic therapy (PDT) in treatment patients with 1. Study Design This phase IIa prospective double‐blind randomized 1 into three groups: HAL vaginal suppository, placebo suppository or follow‐up only. Patients first two groups received suppositories 5 hours before...
Inguinal sentinel lymph node dissection has been shown to be safe in early vulvar cancer several studies and is considered or even recommended many guidelines. The prognosis of inguinal recurrence often poor associated with significant mortality. To ensure an acceptably low false-negative rate recurrence, should only performed using high-quality standards. This retrospective study aims investigate the incidence isolated groin daily practice six large centers Germany. We identified all...
Cervical cancer (CC) remains the fourth most common malignancy in women worldwide. Current treatments primarily consist of surgery and combined radiochemotherapy, while targeted therapies, as seen other malignancies, remain underdeveloped. The G-protein-coupled estrogen receptor (GPER1) is implicated various cancers can differentially influence tumor behavior, though its precise role CC unclear, with both tumor-promoting tumor-suppressive effects reported. We previously explored impact...
Cervical cancer (CC) is the fourth most common in women worldwide. There are two main histological subtypes of CC: more cervical squamous cell carcinoma (CSCC) and rarer adenocarcinoma (CAC), which has a poorer prognosis. Unlike estrogen receptor (ER) α ERβ, G-protein-coupled 1 (GPER1) recognized as rapid mediator cellular estrogenic action tends to have tumor suppressive properties CC. Since clinical study showed that an elevated GPER1 expression associated with worse prognosis, we...
The effect of G-protein-coupled estrogen receptor 1 (GPER1) on tumors depends tumor entity, with its expression level influencing signal transduction and function. Recent research suggests that GPER1 promotes suppression in cervical carcinoma (CC). In contrast, silencing increases serpin family E member (SERPINE1) protein, plasminogen activator inhibitor-1 (PAI-1), progression, raising the question whether PAI-1 might be a suitable target for treatment CC. To explore this, we examined impact...
e17650 Background: In early-stage vulvar cancer, sentinel lymph node biopsy (SNB) is an accepted method for surgical staging of the groin nodes. However, risk recurrence higher compared to full dissection groin. To weigh risks and benefits, data on prognosis after isolated following a negative SNB are missing. Methods: This retrospective, multicenter AGO study group included patients (pts) with primary node-negative cancer who underwent local tumor resection only between 2010 2021, later...