A5038716706- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Particle accelerators and beam dynamics
- Boron Compounds in Chemistry
- Gamma-ray bursts and supernovae
- Muon and positron interactions and applications
- Pancreatic function and diabetes
- Medical Imaging Techniques and Applications
- Radiation Effects in Electronics
- Complement system in diseases
- Risk and Safety Analysis
- Cannabis and Cannabinoid Research
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Head and Neck Cancer Studies
- Effects of Radiation Exposure
- Particle Detector Development and Performance
- Atmospheric and Environmental Gas Dynamics
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Characterization
- Electronic Packaging and Soldering Technologies
- Advanced X-ray and CT Imaging
- Ultrasound and Hyperthermia Applications
National Institutes for Quantum Science and Technology
2023-2025
Fujieda Municipal General Hospital
2019-2024
Osaka University
2023
Tokyo Women's Medical University
2011-2021
Waseda University
2018
Cerium-doped Gd3(Ga, Al)5O12 (GAGG:Ce) is a promising novel scintillator for gamma-ray detectors. While GAGG:Ce has already been implemented in various commercial products, its detailed characteristics and response to high-energy particles gamma rays remain unknown. In particular, knowledge lacking on the radiation tolerance of this against proton irradiation expected future space satellite mission applications. study, we first investigate light-yield energy dependence, resolution, decay...
Abstract Imaging of nuclear gamma-ray lines in the 1–10 MeV range is far from being established both medical and physical applications. In proton therapy, 4.4 gamma rays are emitted excited nucleus either 12 C* or 11 B* considered good indicators dose delivery and/or verification. Further, astronomy, produced by cosmic ray interactions interstellar medium, can thus be used to probe nucleothynthesis universe. this paper, we present a high-precision image taken newly developed 3-D position...
Monitoring the in vivo dose distribution proton therapy is desirable for accurate irradiation of a tumor. Although positron emission tomography (PET) widely used confirmation, obtained emitters produced by protons does not trace due to different physical processes. To estimate from PET image, cross sections nuclear reactions that produce are important yet far being sufficient. In this study, we measured 16O(p,x)15O, 16O(p,x)13N, and 16O(p,x)11C with wide-energy range (approximately 5-70 MeV)...
Abstract Objective. The tumor microenvironment characterized by heterogeneously organized vasculatures causes intra-tumoral heterogeneity of oxygen partial pressure at the cellular level, which cannot be measured current imaging techniques. may lead to a reduction therapeutic effects radiation. purpose this study was investigate on biological effectiveness H-, He-, C-, O-, and Ne-ion beams for different oxygenation levels, prescribed dose cell types.
Approach. distributions were...
Radiotherapy for localized prostate cancer often targets the entire with a uniform dose despite presence of high-risk dominant intraprostatic lesions (DILs). This study investigated feasibility focal dose-averaged linear energy transfer (LETd) boost carbon-ion radiotherapy to deposit higher LETd DILs while ensuring desired relative biological effectiveness weighted coverage and sparing organs at risk (OARs). A retrospective planning was conducted on 15 cases. The were identified...
In order to initiate multi-ion therapy for head and neck cancers, it is necessary predetermine the target dose-averaged linear energy transfer (LETd) prescription gross tumor volume (GTV). This study investigated LETdoptimized treatment plans with carbon-, oxygen-, neon-ion beams demonstrated their potential efficacy against hypoxia.
Approach: Sixteen cancer patients GTV sizes ranging from 5.5 143.1 cm3were selected this retrospective planning study. Carbon, oxygen, neon ions were used...
Abstract The use of proton therapy has the advantage high dose concentration as it is possible to concentrate on tumor while suppressing damage surrounding normal organs. However, range uncertainty significantly affects actual distribution in vicinity range, limiting benefit for reducing By measuring annihilation gamma rays from produced positron emitters, obtain a induced emission tomography (pPET) image according irradiation region beam. Smoothing with Gaussian filter generally used...
Positron emission tomography (PET) has been extensively studied and clinically investigated for dose verification in proton therapy. However, the production distributions of positron emitters are not proportional to distribution. Thus, direct evaluation is limited when using conventional PET-based approach. We propose a method estimating distribution from emitter maximum likelihood (ML) expectation maximization (EM) algorithm combined with filtering. In experiments verify effectiveness...
Abstract Objective . Helium, oxygen, and neon ions in addition to carbon will be used for hypofractionated multi-ion therapy maximize the therapeutic effectiveness of charged-particle therapy. To use new cancer treatments based on dose-fractionation protocols established carbon-ion therapy, this study examined cell-line-specific radioresponse helium-, oxygen-, neon-ion beams within wide dose ranges. Approach Response cells was described by stochastic microdosimetric kinetic model. First,...
Positron emission tomography (PET) has been used for in vivo treatment verification, mainly range proton therapy. Evaluating the direct dose from PET measurements remains challenging; however, it is highly desirable a clinical perspective. In this study, method estimating distribution positron emitter distributions was developed using maximum likelihood expectation maximization algorithm. The 1D spatial relationship between and an inhomogeneous target inputted into system matrix based on...
At the National Institutes for Quantum Science and Technology (QST), a multi-ion therapy using helium, carbon, oxygen, neon ions has been studied charged particle with more optimal biological effects. To make clinically feasible, new treatment system was developed to realize changes of ion species in each irradiation Heavy Ion Medial Accelerator Chiba (HIMAC). Since radiation is safety-critical, it necessary construct safety that includes multiple barriers perform analysis prevention serious...
The solder flip chip attach without flux using plasma treatment has been developed in order to eliminate the residue cleaning process for manufacturing BGA/CSP packages. is composed of roughening surface and improving wettability. Argon gas added hydrogen (Ar+H/sub 2/) very superior argon etching/roughening surface, therefore, a mixed carbon tetrafluoride or oxygen(CF/sub 4//Ar CF/sub 4//O/sub modified good solderability damage Si chip, passivation film organic substrate because active...
Introduction: Our experimental approach toward the development of novel treatments for diabetes mellitus has allowed us to create a monolayered contiguous sheet (islet cell sheet), which can be transplanted and engrafted subcutaneously (Shimizu et al, Biomaterials, 2009). For fabricating an islet sheet, dispersed cells were seeded onto temperature responsive polymer, poly(N-isopropylacrylamide) (PIPAAm), grafted culture dish coated with rat laminin 5 (RL5). The transplant sheets allows hyper...