A5056484507- Cardiac Arrhythmias and Treatments
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Enzyme Production and Characterization
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Photosynthetic Processes and Mechanisms
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Coronary Artery Anomalies
- Cardiovascular and Diving-Related Complications
- Enzyme Structure and Function
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Cardiovascular and exercise physiology
- Cardiovascular Conditions and Treatments
- Ion channel regulation and function
- Biochemical and biochemical processes
- Non-Invasive Vital Sign Monitoring
- Biochemical Acid Research Studies
- Hemoglobin structure and function
Leipzig Heart Institute
2016-2025
Deutsches Herzzentrum der Charité
2012-2025
Leipzig University
2012-2024
Leipzig/Halle Airport
2021
University Hospital Leipzig
2018-2021
Institut für Angewandte Trainingswissenschaft
2020
Charité - Universitätsmedizin Berlin
2020
University of Birmingham
2019
National Center on Birth Defects and Developmental Disabilities
2019
Centers for Disease Control and Prevention
2019
There are 16 epsilon-amino groups of lysyl residues which essential for the activity ribulose-1,5-bisphosphate carboxylase/oxygenase. These formed a Schiff base with pyridoxal 5'-phosphate was stabilized by NaBH4 reduction. The stoichiometry covalently bound after reduction determined spectrophotometrically derived molar extinction coefficient 4800 M-1 cm-1. incorporation into protein accompanied loss carboxylase and oxygenase activities, but ratio their activities remained constant. Vmax,...
Abstract Aims Contemporary data from prospective multicentre registries on catheter ablation in pediatric patients are sparse. Aim of the European Pediatric Catheter Ablation Registry EUROPA was to contribute fill this gap knowledge. Methods and results From July 2012 June 2017, (≤18 years age) including a 1-year follow-up five EP centres were collected prospectively. A total 683 (mean age 12.4 ± 3.9 years, mean body weight 50.2 19 kg) enrolled. Target tachycardia WPW/atrioventricular-nodal...
Subcutaneous-implantable cardiac defibrillators (S-ICDs) are used increasingly to prevent sudden death in young patients. This study was set up gain insight the indications for S-ICD, possible complications, and their predictors follow-up results.A multicentre, observational, retrospective, non-randomized, standard-of-care registry on S-ICD outcome patients with congenital heart diseases (CHDs), inherited arrhythmias (IAs), idiopathic ventricular fibrillation (IVF), cardiomyopathies (CMPs)....
Cardiac pacing is sometimes required for patients with congenital heart disease various reasons. Because of complex anatomy, repetitive previous surgery and patient size, epicardial leads are special importance in these patients. Using has been discussed controversly regarding performance lead survival. The aim this study was to review the long-term data on as well survival implanted our center. Retrospective chart literature. 82 consecutive pediatric or adult 158 (Medtronic 4968, bipolar,...
Telemedicine gained an increasing use throughout the last years. Lifestyle tools like Apple watch seem to have spread even in remote areas and underdeveloped regions. The availability of these offers chance health care functions devices improve provision professional medical care. First data on Watch as a monitoring device children been reported, showing good acceptability usability for symptom children. This study aimed evaluate accuracy iECG comparison standard 12-lead ECG pre-term...
Diving and fin swimming are well established sports, including competitive but little is known about the short-term adaptation of physiological parameters in Children Adults during submersed dynamic apnea near individual maximum. The current study provides data on young to diving real-life conditions. This from 11 healthy elite swimmers (<30 years), transcutaneous oxygen saturation heart rate performing various protocols. results suggest that duration primarily affects saturation, while dive...
Soybean (Glycine max [L.] Merr.) ovary growth was measured from anthesis to 6 days after (DAA) establish a timetable of biochemical events that might be useful in identifying processes initiate abscission. Two procedures were developed provide samples with either high or low percent pod set for ;IX93-100,' semideterminate line having long racemes. Characteristics fresh and dry weight, soluble insoluble protein, carbohydrate, starch, RNA, DNA. Setting ovaries grew more rapidly than abscising...
Aim: Junctional ectopic tachycardia (JET) is a postoperative complication with mortality rate of up to 14% after surgery for congenital heart disease. This study evaluated the risk factors JET and explored association temporary third degree atrioventricular (AV) block occurrence JET. Materials Methods: Data were collected retrospectively from 1158 patients who underwent Results: The overall incidence was 2.8%. Temporary AV occurred in 1.6% cases. Permanent requiring pacemaker implantation 1%...
Abstract As part of a program to discover improved glycoside hydrolase family 12 (GH 12) endoglucanases, we have extended our previous work on the structural and biochemical diversity GH homologs include most stable fungal found, Humicola grisea Cel12A. The H. enzyme was much more irreversible thermal denaturation than Trichoderma reesei enzyme. It had an apparent midpoint ( T m ) 68.7°C, 14.3°C higher T. There are additional three cysteines found in Cel12A To determine their importance for...
Abstract Background: In recent years, the importance of telemedicine has increased significantly. Especially in field echocardiography, virtual reality glasses offer possibility real-time data transmission without restrictions examination process. particular, care critically ill newborns with suspected CHD might be improved by allowing a specialized paediatric cardiologist to remotely guide an echocardiographic examination. The current study aims prove whether novices, under Google Glass...
The structural nature of the iron-sulfur clusters NADH dehydrogenase from beef heart mitochondria has been studied by cluster extrusion technique.Enzyme samples were unfolded anaerobically in 80% (v/v) hexamethylphosphoramide/aqueous buffer presence 0-xylyl-a,a'-dithiol as displacing agent and extruded then reacted with ptrifluoromethylbenzenethiol analyzed Fourier transform "F NMR at 339 MHz.Whenever was nearly complete, both binuclear tetranuclear found a mole ratio -2:l.Thus,...
To validate the physical and psychological effectiveness of cardiac pacing in pediatric patients with breath-holding spells (BHS) prolonged asystole.The records clinical data all BHS who presented to our center period 2001-2013 were reviewed. All received pacemaker implantation for asystole during included. In addition, parents asked fill out a standardized quality life (QOL) questionnaire.Seven identified. The mean onset symptoms was 7 month (1-12 months) age, documented 12-21 seconds,...
This study evaluates the accuracy of iECGs in comparison to gold standard ECG adult patients with congenital heart disease and recommends appropriate iECG derivation based on patient's characteristics. In 106 adults (51 female, 55 male) disease, a 12-lead was recorded, followed by three Apple Watch series 4, which correspond Einthoven leads I, II, III. Two experienced independent cardiologists analyzed time intervals, amplitudes, polarities parameters as well rhythm type correlated patient...
Reflex vasovagal-or cardioinhibitory syncope is known to be a major cause of recurrent in children. The mechanism vasovagal (VVS) an interaction between vagally mediated bradycardia or asystole and more less manifest vasodilatory component. Although pacing not advisable as standard approach patients with VVS, it remains treatment option last resort exceptionally severe cases, contraindication refractoriness drug therapy life style changes. To effectively avoid VVS these patients, the...
A simplified procedure for the isolation of NADH dehydrogenase from inner membrane ox heart mitochondria is presented which permits relatively rapid preparation enzyme in a more stable form than that afforded by published methods. The protein thus isolated displays eight different subunits gel electrophoresis under denaturing conditions, three are also present "low-molecular-weight form' prepared drastic conditions. Complex I contains several subunits, mostly low molecular weight, not seen...