A5056419905- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- Multiple Myeloma Research and Treatments
- Kruppel-like factors research
- CAR-T cell therapy research
- Virus-based gene therapy research
- Platelet Disorders and Treatments
- Protein Degradation and Inhibitors
- Angiogenesis and VEGF in Cancer
- Viral Infections and Immunology Research
- Immunodeficiency and Autoimmune Disorders
- Cell Adhesion Molecules Research
- Genomic variations and chromosomal abnormalities
- Renal Transplantation Outcomes and Treatments
- Hemoglobinopathies and Related Disorders
- Wireless Body Area Networks
- Neurogenesis and neuroplasticity mechanisms
- Erythropoietin and Anemia Treatment
- Neutropenia and Cancer Infections
- Heparin-Induced Thrombocytopenia and Thrombosis
- Biosimilars and Bioanalytical Methods
Medizinische Hochschule Hannover
2014-2024
University of Tübingen
2010-2012
Democritus University of Thrace
2012
Molecular genetics may influence outcome for patients with myelofibrosis. To determine the impact of molecular on after allogeneic stem cell transplantation, we screened 169 primary myelofibrosis (n = 110), post-essential thrombocythemia/polycythemia vera 46), and in transformation 13) mutations 16 frequently mutated genes. The most frequent mutation was JAK2V617F 101), followed by ASXL1 49), calreticulin 34), SRSF2 16), TET2 10), U2AF1 11), EZH2 7), MPL 6), IDH2 5), IDH1 4), CBL 1)....
Abstract Splenomegaly is the clinical hallmark of myelofibrosis. at time allogeneic hematopoietic cell transplantation (HCT) associated with graft failure and poor function. Strategies to reduce spleen size before HCT especially after Janus kinase (JAK) inhibition represent unmet needs in field. Here, we leveraged a global collaboration investigate safety efficacy splenic irradiation as part platform for patients We included 59 patients, receiving within median 2 weeks (range, 0.9–12 weeks)...
Vascular risk factors contribute to the progression of dementia in Alzheimer's disease (AD) and influence platelet activation. However, degree activation as a possible underlying mechanism this has not been studied till now. Significantly higher baseline expression both biomarkers, activated glycoprotein IIb–IIIa complex P-selectin, was observed patients with AD fast cognitive decline compared slow during 1-year follow-up period. These results suggest that could be putative prognostic...
Recent evidence revealed important interactions between clonal hematopoiesis (CH) and cellular therapies established for the treatment of hematologic malignancies. The impact CH on safety, efficacy, outcome chimeric antigen receptor (CAR) T-cell therapy is currently under investigation. We analyzed 110 patients with relapsed/refractory B-cell non-Hodgkin lymphoma (n = 105) or acute lymphoblastic leukemia (ALL) 5), treated Axicabtagene-Ciloleucel (39%), Tisagenlecleucel (51%), Brexucabtagene...
Accelerated-phase myelofibrosis, currently defined by circulating blasts 10% to 19%, usually confers very high risk for progression and poor outcome. The outcome of hematopoietic stem cell transplantation accelerated-phase myelofibrosis has not been evaluated yet. We analyzed the 349 clinically genetically annotated patients with primary or secondary undergoing reduced intensity transplantation, whom 35 had myelofibrosis. In comparison chronic-phase (<10% blasts) median leukocyte counts were...
Objective The aim of this study was to investigate the prevalence cancer and associating clinical, immunological, genetic factors in a German cohort patients with common variable immunodeficiency (CVID). Methods In retrospective monocenter study, we estimated standardized incidence ratio (SIR) for different forms diagnosed CVID patients. Furthermore, evaluated likely association infectious non-infectious CVID-related phenotypes diagnosis by calculation odds ratio. background sequential...
Treatment with CD19 chimeric antigen receptor (CAR) T cells is an innovative therapeutic approach for patients relapsed/refractory diffuse large B cell lymphoma (r/rDLBCL) and B-lineage acute lymphoblastic leukemia (r/rALL). However, convincing response rates can be accompanied by cytokine release syndrome (CRS) severe neurotoxicity termed immune effector cell-associated (ICANS).Single center, prospective observational study of fifteen consecutive r/r DLBCL treated Tisagenlecleucel within 1...
TP53 mutations (TP53MT) have been associated with poor outcomes in various hematologic malignancies, but no data exist on its role patients myelofibrosis undergoing hematopoietic stem cell transplantation (HSCT). Here, we took advantage of a large international multicenter cohort to evaluate the TP53MTin this setting. Among 349 included patients, 49 (13%) had detectable TP53MT, whom 30 showed multi-hit configuration. Median variant allele frequency was 20.3%. Cytogenetic risk favorable...
Hyperlipidemia is associated with platelet hyperactivity. In the present study, we evaluated binding of oxidized low-density lipoprotein (oxLDL) on surface circulating platelets in patients stable coronary artery disease and acute syndromes its possible association activation. Furthermore, role oxLDL adhesion to collagen endothelial cells vitro as well after carotid ligation mice was investigated.Using flow cytometry, (n=174) showed significantly enhanced compared (n=182; P=0.007)....
Abstract The inclusion of mutation status improved risk stratification for newly diagnosed patients with chronic myelomonocytic leukemia (CMML). Stem cell transplantation is a potentially curative treatment option, and patient selection critical because relevant transplant-related morbidity mortality. We aimed to evaluate the impact together clinical presentations on posttransplant outcome. Our study included 240 median follow-up 5.5 years. A significant association worse survival was...
The aim of our study was to analyze the potential survival benefit associated with HSCT according clinico-biological scores which incorporate molecular data (MIPSS70 and MIPSS70+V2) facilitate decision-making in this context. One transplant (n=241) one non-transplant cohorts (n=239) were used test hypothesis that PMF patients higher risk score from HSCT. A weighted propensity applied balance confounding factors transplanted cohort as reference. Weighted Cox proportional hazard models...
To investigate the role of junctional adhesion molecule A (JAM-A) on and differentiation human CD34(+) cells into endothelial progenitor cells.Tissue healing vascular regeneration is a multistep process requiring firm circulating to wall their further cells. The JAM-A in platelet-mediated was investigated by assays vitro with help intravital fluorescence microscopy mice. Preincubation soluble JAM-A-Fc (sJAM-A-Fc) resulted significantly decreased over immobilized platelets or inflammatory...
Cerebrovascular dysfunction is a common finding in patients with Alzheimer's disease (AD) and may contribute to cognitive decline. Abundant evidence suggests that vascular neuronal repair mechanisms are mediated by circulating progenitor cells
There is no direct evidence to recommend specific conditioning intensities in myelofibrosis undergoing allogeneic hematopoietic cell transplantation, especially the molecular era. We aimed compare outcomes of reduced intensity (RIC) or myeloablative (MAC) transplantation with information. The study included 645 genetically annotated patients (with at least driver mutation status available), whom 414 received RIC and 231 MAC. median follow-up time from was 6.0 years for 9.4 6-year overall...
The critical question in the management of chronic myelomonocytic leukemia (CMML) is which patients may benefit from allogeneic hematopoietic cell transplantation (allo-HCT). Using ad hoc statistical analysis, we designed a multicenter retrospective study to determine outcomes 261 age ≤70 years at diagnosis who underwent allo-HCT (n = 119) compared with those did not 142) according current CMML-specific prognostic scoring system (CPSS). Categorizing as lower risk (CPSS low/intermediate-1) or...
Vaccine-induced thrombotic thrombocytopenia (VITT), or thrombosis with syndrome (TTS), is a rare but serious complication of adenovirus-based vaccines against severe respiratory coronavirus 2 (SARS-CoV-2). Observation long-term outcomes important to guide treatment affected patients. This single-center consecutive cohort study included all patients diagnosed based on (1) vaccination 4 21 days before symptom onset, (2) signs symptoms venous arterial thrombosis, (3) < 150/nL, (4) positive...
Abstract Isolated myeloid sarcoma (MS) is a rare malignancy in which blast forms tumors at various locations while the bone marrow (BM) remains cytomorphologically free from disease. We analyzed isolated MS four patients and their BMs initial diagnosis follow-up, using custom next-generation sequencing (NGS) panel. observed possible clonal evolution hematopoiesis of indeterminate potential (CHIP)-like finding BM one three cases with detectable mutations. Clinical presentation patient...
Background: CD34+ progenitor cells play an important role in haematopoiesis and vascular homeostasis. The aim of the present study was to investigate platelet-derived junctional adhesion molecule-C (JAM-C) differentiation human vitro, as well its association with P-selectin patients coronary artery disease. Methods Results: Using flow cytometry we observed that JAM-C expression on surface washed platelets is increased after activation thrombin receptor activating peptide-6 vitro correlated...
Type 31 of human adenovirus species A (HAdV-A31) is a significant pathogen primarily associated with diarrhoea in children but also life-threatening disseminated disease allogeneic haematopoietic stem cell transplant (HSCT) recipients. Nosocomial outbreaks HAdV-A31 have been frequently described. However, the evolution has not studied detail. The other HAdV types driven either by intertypic recombination, where different exchange genome regions, or immune escape selection neutralisation...
Abstract Acute and chronic graft-versus-host disease (GvHD) are major complications of allogeneic hematopoietic cell transplantation (alloHCT). In vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG) as part the conditioning regimen prior to alloHCT is frequently used GvHD prophylaxis, but data on its role in myelofibrosis scarce. We took advantage an international collaborative network investigate impact ATLG undergoing first alloHCT. included 707 patients ( n = 469 238 non-ATLG...