A5067731182- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Esophageal and GI Pathology
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- RNA Interference and Gene Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- MRI in cancer diagnosis
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Enhanced Recovery After Surgery
- Medical Imaging and Pathology Studies
- Cancer survivorship and care
- Oral and gingival health research
Wakayama Medical University
2015-2024
Nara Medical University
2023
Kansai Medical University
2023
Quality and Reliability (Greece)
2018
Second Hospital of Nanchang
2017
National Institute of Biomedical Innovation, Health and Nutrition
2016
Japan Pancreatic Disease Research Foundation
2013
Identification of predictors malignancy for branch duct type intraductal papillary mucinous neoplasms (IPMN).Main IPMN has been recommended resection. However, the indications resection have controversial.We retrospectively analyzed clinicopathological factors 134 patients undergoing IPMN, excluding main to identify malignant behavior this neoplasm. The cutoff values tumor size, pancreatic (MPD) mural nodule and carcinoembryonic antigen (CEA) level in juice obtained during preoperative...
This study used a randomized controlled trial (RCT) to evaluate whether mattress suture of pancreatic parenchyma and the seromuscular layer jejunum (modified Blumgart method) during pancreaticojejunostomy (PJ) decreases incidence clinically relevant postoperative fistula (POPF) after pancreaticoduodenectomy (PD).Several studies reported that anastomosis in PJ could reduce POPF rate. This, however, is first RCT.Between June, 2013 May, 2017, 224 patients scheduled for PD were enrolled this...
The invasion process is a crucial step for pancreatic ductal adenocarcinoma (PDAC); however, the genes related to remain unclear. To identify specific process, we compared microarray data infiltrating cancer and PanIN-3, which were harvested from an individual PDAC patient by microdissection. Furthermore, immunohistochemical, coimmunoprecipitation analyses performed confirm biologic significance of molecules identified expression profile. In present study, focused on MUC16 mesothelin among...
Objectives This single‐center comparative randomized superiority study compared biliary stenting using fully covered self‐expandable metal stents (FCSEMS) and plastic (PS) in preoperative drainage of patients with borderline resectable pancreatic cancer (BRPC) who are planned to undergo a single regimen neo‐adjuvant chemotherapy (NAC). Methods Twenty‐two BRPC required before NAC (Gemcitabine plus Nab‐paclitaxel) were randomly assigned 1:1 the FCSEMS or PS group. The primary endpoint was rate...
Abstract Background Pancreaticoduodenectomy (PD) is associated with a high incidence of postoperative complications including pancreatic fistula. This randomized clinical trial compared the fistula between isolated Roux-en-Y (IsoRY) and conventional reconstruction (CR) methods. Methods Patients admitted for PD June 2009 September 2012 in single centre were assigned randomly to CR or IsoRY. The primary endpoint was (grade A–C) defined according International Study Group on Pancreatic Fistula....
Abstract Purpose We investigated the potential clinical utility of short-term serial KRAS -mutated circulating cell-free tumor DNA (ctDNA) assessment for predicting therapeutic response in patients undergoing first-line chemotherapy advanced pancreatic cancer. Methods collected 144 blood samples from 18 with locally or metastatic cancer that were initial gemcitabine plus nab-paclitaxel (GEM nab-PTX). Analysis ctDNA was quantified by digital droplet polymerase chain reaction (ddPCR) as mutant...
Background/Aim: The aim of this study was to investigate the safety and feasibility neoadjuvant nab-paclitaxel plus gemcitabine therapy for patients with borderline resectable pancreatic carcinoma (BRPC). Patients Methods: a prospective single-center phase I trial BRPC. primary endpoint toxicity, secondary endpoints were resection rate, R0 rate quality life (QOL) regarding peripheral sensory neuropathy (PSN). This registered on UMIN Clinical Trials Registry (UMIN000018382) ClinicalTrials.gov...
<h3>Importance</h3> Invasive intraductal papillary mucinous carcinoma has aggressive malignant behavior, including lymph node metastasis. It is important to identify factors associated with invasive determine operative procedures, but they remain unclear. <h3>Objective</h3> To the specific neoplasms for branch duct, main and mixed type carcinomas. <h3>Design, Setting, Participants</h3> Retrospective cohort study of 286 consecutive patients who underwent surgical resection neoplasm from July...
We evaluated whether neoadjuvant therapy followed by surgical resection improves the clinical outcome for patients with borderline resectable pancreatic cancer radiologic artery involvement (BRPC-A).We reviewed 143 BRPC-A from among 330 patients, including 111 potentially and 76 portal/superior mesenteric vein who underwent surgery at Wakayama Medical University Hospital. compared clinicopathological factors of 40 treated those 103 upfront surgery.The R0 rate progression-free survival...
Abstract Mesenteric approach is an artery‐first during pancreaticoduodenectomy (PD). In the present study, we evaluated clinical and oncological benefits of this procedure for pancreatic ductal adenocarcinoma (PDAC) pancreas head. Between 2000 2015, 237 consecutive PDAC patients underwent PD. Among them, 72 experienced mesenteric (mesenteric group) 165 conventional (conventional group). A matched‐pairs group consisted 116 (58 in each matched age, gender, resectability status, neoadjuvant...
The aim of this study was to classify the variations anatomical tributaries colic drainage veins into gastrocolic trunk Henle detected by three-dimensional multidetector computed tomography understand surgical vascular anatomy during pancreaticoduodenectomy.One hundred and twenty patients who underwent studies before pancreaticoduodenectomy were retrospectively reviewed.The identified in 100 (83.3%) tomography. described classified four types based on number (superior right vein, vein middle...