The use of nanoparticle delivery systems to enhance intracellular penetration antibiotics and their retention time is becoming popular. challenge, however, that the interaction nanoparticles with biological at cellular level must be established prior biomedical applications. Ciprofloxacin-cockle shells-derived calcium carbonate (aragonite) (C-CSCCAN) were developed characterized. Antibacterial activity was determined using a modified disc diffusion protocol on Salmonella Typhimurium (S....

The demands for applicable tissue-engineered scaffolds that can be used to repair load-bearing segmental bone defects (SBDs) is vital and in increasing demand. In this study, seven different combinations of 3 dimensional (3D) novel nanocomposite porous structured were fabricated rebuild SBDs using an extraordinary blend cockle shells (CaCo3) nanoparticles (CCN), gelatin, dextran dextrin structure ideal scaffold with adequate degradation rate the Freeze Drying Method (FDM) labeled as 5211,...

Abstract: Calcium carbonate is a porous inorganic nanomaterial with huge potential in biomedical applications and controlled drug delivery. This study aimed at evaluating the physicochemical properties vitro efficacy safety of cockle shell aragonite calcium nanocrystals (ANC) as therapeutic hormonal delivery vehicle for osteoporosis management. Free human recombinant parathyroid hormone 1-34 (PTH 1-34)-loaded (PTH-ANC) were synthesized evaluated using standard procedures. Transmission...

Background: Osteosarcoma (OS) is a highly malignant primary bone cancer. Severe side effects and multidrug resistance are obstacles faced with chemotherapy against OS. With the hope to overcome of conventional chemotherapy, various targeted drug delivery systems using nanotechnology have been explored in past few decades. Biogenic calcium carbonate (CaCO3) has great potential be smart system.Results: In this study, cockle shells-derived aragonite nanoparticles (ANPs) were developed loaded...

Purpose: Modified top-down procedure was successfully employed in the synthesis of aragonite nanoparticles (NPs) from cheaply available natural seawater cockle shells. This with aim developing a pH-sensitive nano-carrier for effective delivery doxorubicin (DOX) on MCF-7 breast cancer cell line. Methods: The shells were cleaned banana pelts, ground using mortar and pestle, stirred vigorously rotary pulverizing blending machine dodecyl dimethyl betane solution. simple avoids use stringent...

Calcium carbonate nanoparticles have shown promising potentials in the delivery of drugs and metabolites. There is however, a paucity information on safety their intentional or accidental over exposures to biological systems general health safety. To this end, study aims at documenting subcutaneous doses biogenic nanocrystals aragonite polymorph calcium derived from cockle shells (ANC) Sprague-Dawley (SD) rats. ANC was synthesized using top-down method, characterized transmission electron...

The one-humped camel, Camelus dromedarius, is an important pack and ride, dairy meat animal in semi-arid northeastern Nigeria. This study was carried out to document reproductive information for scientists farmers on camel rearing improved productivity. A structured open-ended questionnaire herd growth parameters constraints of camel-rearing the region administered 147 respondents. Results showed that most owners were middle aged, married, Arab men with over 20 years experience...

One of the most prevalent death causes among women worldwide is breast cancer. This study aimed to characterise and differentiate proteomics profiles cancer cell lines treated with Doxorubicin (DOX) Doxorubicin-CaCO3-nanoparticles (DOX-Ar-CC-NPs). determines therapeutic potential doxorubicin-loaded aragonite CaCO3 nanoparticles using a Liquid Chromatography/Mass Spectrometry analysis. In total, 334 proteins were expressed in DOX-Ar-CC-NPs cells, while DOX treatment only 54 proteins. Out...

Abstract Prenatal gross morphologic, morphometric and histologic developmental features of the dromedary spleen were studied. The gestation period (13 months) was categorized into four (1-4) phases ten developing spleens per growth phase sampled. Splenic topographical anatomy noted before being eviscerated from each foetus. Morphologic immediately documented 2 – 4 mm thick samples collected for histological analysis. dark brown in colour, semilunar shaped significantly increased (p<0.05)...

The study aims to present baseline data on the reproductive anatomy of a poorly known tropical deer species, Rusa (Rusa timorensis). female system is described using seven uniparous hinds, aged between four and eight years. various structures were studied via standard descriptive methods. There was significant difference in length width both right left ovaries. ovary slightly larger than which indicates that it physiologically more active. results showed R. timorensis similar observed...

aimed at investigating the unique mor- phological features and number of bones making up this region an-

The African lion (Panthera leo) is the largest carnivore. Despite being best studied mammalian species in ecosystem, there still exist a dearth of information on morphology its skeletal components, which vital for diagnoses bone diseases and archeological study. To this end, study was aimed at documenting morphological features number bones making up axial skeleton. It conducted using two (2) lions that were obtained different times after post mortem examinations their carcasses Department...

This study on the gross anatomy of West African giraffe’s hind limb was aimed at investigating unique morphological features and number bones making up this region skeleton. Two (2) adults obtained as carcasses different times after postmortem examination were prepared to extract via cold water maceration for use in study. The appearance ossa coxarum its presented similarities that horse. However, differences evident convex cranial border ilium, small less prominent coxal tuber, wider...

Abstract The Guinea fowl ( Numida meleagridis ) is a semi-domestic bird whose commercial popularity on the increase. gross anatomy of hindlimbs 8 helmeted fowls equal sexes were studied. pubic shafts free, thus they did not fuse ventrally to form symphysis. ilium had quadrilateral and roughly triangular pre post acetabular wings, respectively. A conspicuous renal fossa was observed in wing. An incomplete concentric obturator foramen, lacking caudal margin, formed by ventral border ischium...

Event Abstract Back to Apoptotic evaluation and cytotoxic effects of doxorubicin conjugated CaCO3-nanoparticles on breast cancer cell-line Hamidu Ahmed1, Mokrish Ajat2, Rozaihan Mansor2, Intan Shameha Abdul Razak2, Abubakar Danmaigoro2, Alhaji Zubair Jaji2, Jaafaru Sani Mohammed3 Md Zuki Abu Bakar2* 1 Laboratory Molecular Biomedicine, Institute Bioscience, University Putra Malaysia, Malaysia 2 Faculty Veterinary Medicine, University, 3 MAKNA Cancer Research, Background Breast is the most...

This study on the morphological features of bones helmeted guinea fowl (Numidia meleagridis) specifically axial skeleton was conducted for documentation and valuable information differences when compared with other species same order. Ten (10) Helmeted fowls (5 females 5 males) an average weight 3.0 kg were euthanized via jugular vein severance bone preparation achieved use insect larvae. The skull presented elongated structure made up paired unpaired flat, short long distinctive features....

Abstract Background: Anatomical features of the skeleton wild animals contribute largely to their adaptation. A dearth information on skeletal anatomy sitatunga ( Tragelaphus Spekii ) necessitated this study. Two adult carcasses weighing 54kg and 57kg were obtained after post-mortem examination. Bone preparation was achieved through cold water maceration protocol. Result: The tympanic bulla elongated massive, resulting in rudimentary appearance styloid muscular processes temporal bone....

Abstract Background: The Importance of the appendicular skeleton in conformation, shape and physiology wild animals especially carnivores for adaptation survival cannot be overemphasized as limited obsolete information on bones forelimb necessitated this study. Matured adult African lions (Male female) that weighed 173kg 112kg were obtained at different times after post mortem examinations their carcasses. Bone preparation was achieved via cold water maceration proper skin muscle removal to...

The Importance of the appendicular skeleton in conformation, shape and physiology wild animals especially carnivores for adaptation survival cannot be overemphasized, as limited obsolete information on bones forelimb necessitated this study. Matured adult African lions (Male female) that weighed 173 kg 112 were obtained at different times after post mortem examinations their carcasses. Bone preparation was achieved via cold water maceration proper skin muscle removal to a barest minimum.The...