A5090217201- Phytochemistry Medicinal Plant Applications
- Carcinogens and Genotoxicity Assessment
- Colorectal Cancer Treatments and Studies
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Glioma Diagnosis and Treatment
- Phytochemical compounds biological activities
- Liver Disease Diagnosis and Treatment
- Head and Neck Cancer Studies
- Essential Oils and Antimicrobial Activity
- Cancer Treatment and Pharmacology
- Morinda citrifolia extract uses
- Liver physiology and pathology
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Heat shock proteins research
- Gastric Cancer Management and Outcomes
- Neuroscience and Neuropharmacology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Radiation Effects and Dosimetry
- Cancer Cells and Metastasis
- Traumatic Brain Injury and Neurovascular Disturbances
- Natural product bioactivities and synthesis
- Colorectal and Anal Carcinomas
Universidade Luterana do Brasil
2016-2025
Indiana University School of Medicine
2019
Universidade Federal do Rio Grande do Sul
1999-2009
Anticancer Fund
2005
Apoptose, ou morte celular programada, é um processo essencial para a manutenção do desenvolvimento dos seres vivos, sendo importante eliminar células supérfluas defeituosas. Durante apoptose, célula sofre alterações morfológicas características desse tipo de celular. Tais incluem retração da célula, perda aderência com matriz extracelular e vizinhas, condensação cromatina, fragmentação internucleossômica DNA formação corpos apoptóticos. Muitas são as moléculas envolvidas no controle das...
Abstract 5‐Fluorouracil (5‐FU) is an antineoplasic drug widely used to treat cancer. Its cytotoxic effect has been principally ascribed the misincorporation of fluoronucleotides into DNA and RNA during their synthesis, inhibition thymidylate synthase (TS) by FdUMP (one 5‐FU active metabolites), which leads nucleotide pool imbalance. In present study, we compared ability induce apoptosis influence cell cycle progression in human colon SW620 adenocarcinoma cells regards genotoxic clastogenic...
Biochemical markers of cellular stress/injury have been proposed to indicate outcome after head injury. The aim the present study was determine whether plasma von Willebrand factor (VWF) levels correlate with primary and clinical variables in severe traumatic brain injury (TBI). Forty-four male patients, victims TBI, were analyzed. Clinical TBI comprised survival neurological assessment using Glasgow Outcome Scale (GOS) at intensive care unit (ICU) discharge. Computerized tomography (CT)...
Abstract Background Radiation therapy is routinely prescribed for high-grade malignant gliomas. However, the efficacy of this therapeutic modality often limited by occurrence radioresistance, reflected as a diminished susceptibility irradiated cells to undergo cell death. Thus, have evolved an elegant system in response ionizing radiation induced DNA damage, where p53, Hsp70 and/or EGFr may play important role process. In present study, we investigated whether content and are associated...
Radiation therapy is routinely prescribed for high-grade malignant gliomas. However, the efficacy of this therapeutic modality often limited by occurrence radioresistance, reflected as a diminished susceptibility irradiated cells to undergo apoptosis. Heat-shock proteins (Hsps) synthesis can be increased cellular insults, such radiation-induced damage. Inducible Hsp70 has been suggested have multiple roles in cytoprotection against Accordingly, high levels prevent stress-induced In present...
Abstract Clin Chem Lab Med 2006;44:1234–42.
The prediction of outcome is one the major problems associated with traumatic brain injury. Recently, investigations have been performed on potential use circulating cell-free DNA in plasma for clinical diagnosis and prognosis a variety conditions. In this study, we investigated concentrations after severe injury (TBI) its correlation primary outcome. We studied 41 male victims TBI, isolated TBI or exracranial injuries. Control samples were obtained from 13 healthy volunteers. Plasma was...
Mesenchymal stem cells (MSCs) are known for their important properties involving multilineage differentiation potential., trophic factor secretion and localization along various organs tissues. On the dark side, MSCs play a distinguished role in tumor microenvironments by differentiating into tumor-associated fibroblasts or supporting growth via distinct mechanisms. Cisplatin (CIS) is drug widely applied treatment of large number cancers its cytotoxic genotoxic effects, both vitro vivo. Here...
Despite being the world's most widely used system for staging and therapeutic guidance in hepatocellular carcinoma (HCC) treatment, Barcelona clinic liver cancer (BCLC) has limitations, especially regarding intermediate-grade (BCLC-B) tumors. The recently proposed Hong Kong (HKLC) appears useful but requires validation Western populations.
Severe traumatic brain injury (TBI) is associated with a 35-70% mortality rate. Biochemical markers of cellular stress/injury have been proposed to indicate outcome after head injury. Therefore, our aim was determine whether Hsp70 could be detected in the serum patients severe TBI and levels correlate primary TBI. Twenty consecutive male patients, victims (GCS 3-8), were enrolled this prospective study. Clinical variables comprised: survival, time for ICU discharge, neurological assessment...
<b><i>Introduction:</i></b> Sorafenib (SOR) has proved to be effective in patients with advanced hepatocellular carcinoma (HCC), since overall survival was higher phase III clinical trials; however, disease progression can occur. <b><i>Objectives:</i></b> The study aimed describe real-life experience HCC treatment SOR at a university hospital Brazil and estimate the number of indication second-line therapy....
The bark extract from Endopleura uchi has been widely used in traditional medicine to treat gynecological-related disorders, diabetes, and dyslipidemias albeit without scientific proof. In addition, E. safety, especially regarding mutagenic activities, is not known. aim of this study was determine the chemical composition, antitumor, toxicological parameters attributed an aqueous extract. phytochemical constitution assessed by colorimetric chromatographic analyzes. antiproliferative effect...
ABSTRACT The widespread use of electronic devices has led to increased blue light exposure, highlighting the need for effective radiation blockers with protection. Two synthetic 2‐(2′‐hydroxyphenyl)benzoxazole derivatives named azo‐4′‐benzoxazole and azo‐5′‐benzoxazole have shown an unprecedented absorption capacity but had not been subjected a safety evaluation. This study aimed evaluate cytotoxic, genotoxic, mutagenic activities these compounds. cytotoxic genotoxic were evaluated using MTT...
Endopleura uchi bark traditionally used in folk medicine attributed to its anti-inflammatory properties is due the presence of bergenin. This study aimed determine toxicological parameters associated with exposure a phenolic-enriched extract E. and bergenin bioactive byproduct this compound. The total phenolic flavonoid contents were determined through spectrometric analyses, while compounds identified using ultra-performance liquid chromatography coupled high-resolution mass spectrometry...
Abstract. In the current study we present a Gompertzian model for cell growth as function of phenotype using six human tumour lines (A‐549, NCI‐H596, NCI‐H520, HT‐29, SW‐620 and U‐251). Monolayer cells in exponential at various densities were quantified over week by sulforhodamine B staining assay to produce cell‐growth curves. A Gompertz equation was fitted experimental data obtain, each line, three empirical parameters (initial density, rate carrying capacity – maximal density). cell‐shape...