A5083187721- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- Virus-based gene therapy research
- Radiomics and Machine Learning in Medical Imaging
- Supramolecular Self-Assembly in Materials
- Medical Imaging Techniques and Applications
- Chemical Synthesis and Analysis
- Esophageal Cancer Research and Treatment
- Medical Imaging and Pathology Studies
- Ga2O3 and related materials
- Radiopharmaceutical Chemistry and Applications
- Myasthenia Gravis and Thymoma
- Trauma Management and Diagnosis
- Neonatal Respiratory Health Research
- Renal Diseases and Glomerulopathies
- Mesenchymal stem cell research
- Neuropeptides and Animal Physiology
- HVDC Systems and Fault Protection
- Respiratory and Cough-Related Research
- Biotin and Related Studies
- Cancer Cells and Metastasis
- Hepatocellular Carcinoma Treatment and Prognosis
University of Pennsylvania
2022-2023
Ankara Yıldırım Beyazıt University
2023
Hospital of the University of Pennsylvania
2022
Diversified Energy (United States)
2022
Central Institute of Brackishwater Aquaculture
2022
Deccan College of Medical Sciences
2019
KentuckyOne Health
2019
Abstract Purpose: Fluorescence-guided surgery using tumor-targeted contrast agents has been developed to improve the completeness of oncologic resections. Quenched activity–based probes that fluoresce after covalently binding tumor-specific enzymes have proposed specificity, but none tested in humans. Here, we report successful clinical translation a cathepsin probe (VGT-309) for fluorescence-guided surgery. Experimental Design: We optimized dosing, and timing VGT-309 preclinical models lung...
Suspicious nodules detected by radiography are often investigated biopsy, but the diagnostic yield of biopsies small is poor. Here we report a method-NIR-nCLE-to detect cancer at cellular level in real-time during biopsy. This technology integrates cancer-targeted near-infrared (NIR) tracer with needle-based confocal laser endomicroscopy (nCLE) system modified to NIR signal. We develop and test NIR-nCLE preclinical models pulmonary nodule biopsy including human specimens. find that has...
Importance Localization of subcentimeter ground glass opacities during minimally invasive thoracoscopic lung cancer resections is a significant challenge in thoracic oncology. Intraoperative molecular imaging has emerged as potential solution, but the availability suitable fluorescence agents limiting factor. Objective To evaluate suitability SGM-101, carcinoembryonic antigen–related cell adhesion molecule type 5 (CEACAM5) receptor–targeted near-infrared fluorochrome, for imaging–guided...
The diagnostic yield of biopsies solitary pulmonary nodules (SPNs) is low, particularly in sub-solid lesions. We developed a method (NIR-nCLE) to achieve cellular level cancer detection during biopsy by integrating (i) near-infrared (NIR) imaging using cancer-targeted tracer (pafolacianine), and (ii) flexible NIR confocal laser endomicroscopy (CLE) system that can fit within needle. Our goal was assess the accuracy NIR-nCLE ex vivo SPNs.Twenty patients with SPNs were preoperatively infused...
Abstract Pulmonary squamous cell carcinoma is the second most common lung cancer subtype and has a low 5-year survival rate at 17.6%. Complete resection with negative margins can be curative, but high number of patients suffer early postoperative recurrence due to inadequate disease clearance index operation. Intraoperative molecular imaging (IMI) tumor-targeted optical contrast agents effective in improving completeness for other tumor types, there are no IMI tracers targeted pulmonary...
Intraoperative molecular imaging (IMI) using tumor-targeted optical contrast agents can improve cancer resections. The optimal wavelength of the IMI tracer fluorophore has never been studied in humans and major implications for field. To address this question, we investigated 2 spectroscopically distinct fluorophores conjugated to same targeting ligand.Between December 2011 November 2021, patients with primary lung were preoperatively infused 1 folate receptor-targeted tracers: a...
Background. Early detection and complete resection are important prognostic factors for esophageal cancer (EC). Intraoperative molecular imaging (IMI) using tumor-targeted tracers is effective in many types. However, there no EC-specific IMI tracers. We sought to test a cathepsin activity-based tracer (VGT-309) EC resection. Methods. Murine (AKR, HNM007) human (OE19) cell lines were screened expression by western blotting. In vitro binding affinity of VGT-309 was evaluated fluorescence...
Hemoytic uremic syndrome (HUS) is a rare type of thrombotic microangiopathies. Manifestations include thrombocytopenia, microangiopathic hemolytic anemia, and thrombi in small blood vessels. The prognosis poor. Herein, we present case atypical HUS, which very rare.
Supplementary Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
<div>AbstractPurpose:<p>Fluorescence-guided surgery using tumor-targeted contrast agents has been developed to improve the completeness of oncologic resections. Quenched activity–based probes that fluoresce after covalently binding tumor-specific enzymes have proposed specificity, but none tested in humans. Here, we report successful clinical translation a cathepsin probe (VGT-309) for fluorescence-guided surgery.</p>Experimental Design:<p>We optimized dosing, and...
<div>AbstractPurpose:<p>Fluorescence-guided surgery using tumor-targeted contrast agents has been developed to improve the completeness of oncologic resections. Quenched activity–based probes that fluoresce after covalently binding tumor-specific enzymes have proposed specificity, but none tested in humans. Here, we report successful clinical translation a cathepsin probe (VGT-309) for fluorescence-guided surgery.</p>Experimental Design:<p>We optimized dosing, and...
Supplementary Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
Conventional Power generators provides various services in addition to the power generation ensure secure operation of system without any disturbances, these facilities are called ancillary services. Providing voltage stability, frequency control and black start capability basic provided by conventional as a part This paper an overview about how distributed can be used with all functionalities system. It covers analysis IEEE 30 bus modified presence at different penetration levels. Voltage...
Located in the mediastinum, pericardial cysts are rare and benign congenital abnormalities commonly identified as incidental findings on imaging. However, some patients with abnormally enlarged present compressive symptoms, which include recurrent infections, tamponade from cardiac compression respiratory complications. Our report highlights a challenging case of patient symptoms secondary to phrenic nerve compression. Misdiagnosis over past decade resulted ineffective interventions. After...
Abstract Objective: Cancer-associated fibroblasts (CAFs) are a key component of the tumor microenvironment and affect neoplastic progression by stromal remodeling, paracrine signaling, potentiating cancer cell proliferation, immune system evasion. As such, they potential target for optimizing therapeutic diagnostic strategies. The purpose our study was to evaluate if Fibroblast Activation Protein (FAP) can be suitable molecular imaging guided localization during surgery because FAP is...
Abstract Soft-tissue sarcomas (STS) are a group of lethal mesenchymal tumors that major cause cancer related morbidity for those under the age 20.PI3K inhibitors have been found to be effective against subset STS but associated with significant toxicities limiting their use.We thought test selective fibroblast activation protein (FAP) targeted delivery PI3K/AKT/mTOR inhibitor omipalisib in pre-clinical setting as FAP is overwhelmingly expressed agressive soft tissue malignancies....