A5010256223- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- RNA Interference and Gene Delivery
- Digital Accessibility for Disabilities
- Phytochemistry and biological activities of Ficus species
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Dendrimers and Hyperbranched Polymers
- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Web Data Mining and Analysis
- Phytochemistry and Bioactive Compounds
- Graphene and Nanomaterials Applications
- Usability and User Interface Design
- Nanoparticles: synthesis and applications
- Curcumin's Biomedical Applications
- Phytochemical compounds biological activities
- Essential Oils and Antimicrobial Activity
- Computational Drug Discovery Methods
Quaid-i-Azam University
2022-2025
Pakistan Institute of Engineering and Applied Sciences
2022-2023
Pakistan Institute of Nuclear Science and Technology
2022
OsloMet – Oslo Metropolitan University
2020
International Islamic University, Islamabad
2016
A novel combination delivery approach entrapping Sorafenib inside a nanoliposome bilayer and Doxorubicin within the aqueous core to achieve broad-spectrum synergistic chemotherapeutic effect. DOX-SOR liposomes were synthesized by thin film hydration characterized using UV-visible spectroscopy, Fourier Transform Infrared Spectroscopy, Dynamic Light Scattering, Fluorescence, Scanning Electron Microscopy, followed cytotoxicity assessments. Nanoliposomes demonstrated effective loading...
This study is intended to develop a screening method for female breast cancer (BRC) from whole blood using Raman spectroscopy. A multivariate partial least squares (PLS) regression model developed which based upon spectra of BRC-positive and healthy participants. It yields coefficients at the corresponding shifts. These represent changes in molecular structures are associated with progress disease. The present pointed out some specific molecules differentiated groups. In group, rising trend...
Aim: This study aimed to synthesize folate-conjugated sorafenib-loaded (FCSL) liposomes for theranostic application using ultrasound (US). Materials & methods: US parameter optimization, in vitro release, anticancer effect, vivo biodistribution, optical imaging and biocompatibility of were studied. Results: With 84% release after 4 min exposure at 3 MHz (1.2 mechanical index), FCSL showed lower IC50 (8.70 μM) versus sorafenib (9.34 against HepG2 cells. In biodistribution 9 mg/kg injection...
Rapidly evolving drug delivery systems employ therapeutic agents (liposomes, polymers, and nanospheres) to achieve optimum targeted effects with declined side cure chronic diseases like cancer. Nano-formulation of a natural product i.e., Caralluma tuberculata (Ct) extract, has been used as an effective combinational therapy enhanced biocompatibility owing its strong anti-oxidant, anti-inflammatory, anti-bacterial, anti-tumor potential. Ct extract was prepared using three solvents (EtOH,...
Sorafenib, a multi-kinase inhibitor has gained significant attention in cancer therapy. However, the clinical use of sorafenib is limited by poor aqueous solubility, low bioavailability, unfavorable pharmacokinetic properties, and undesirable side effects including anorexia, gastrointestinal bleeding, severe skin toxicity. To overcome these drawbacks, encapsulation into nanocarriers an effective strategy. With advancements nanotechnology, sorafenib[1]based nanoformulation been developed to...