The iris, found in many animal species, is a biological tissue that can change the aperture (pupil) size to regulate light transmission into eye response varying illumination conditions. self‐regulation of lies behind its autofocusing ability and large dynamic range, rendering it ultimate “imaging device” continuous source inspiration science. In optical imaging devices, adjustable apertures play vital role as they control exposure, depth field, aberrations systems. Tunable irises...

To analyze the effect of perioperative decorin in an experimental setting glaucoma filtration surgery.Glaucoma surgery, similar to that performed clinical practice, was on 35 chinchilla rabbits (ChBB:CH). The animals received a unilateral subconjunctival injection (40-100 microg) or vehicle alone before surgery and at different time intervals thereafter. Antifibrotic efficacy established by response histologic examination. were killed day 14, eyes processed for histology.Both solution well...

Purpose: Amniotic membrane transplantation has become an important treatment option for corneal surface reconstruction. However, suture fixation of the transplant various disadvantages like irritation, scarring, graft loss due to shrinkage, and need subsequent removal. Replacement sutures by bioadhesives might be advantageous alternative. This controlled study was designed evaluate a new sutureless technique amniotic onto using fibrin glue. Methods: Standardized disks cryopreserved membranes...

MicroRNAs (miRNAs) are small noncoding RNAs which mediate some of the pathological mechanisms diabetic retinopathy. The aim this study was to identify differentially expressed miRNAs in vitreal exosomes proliferative retinopathy (PDR) patients and non-diabetic controls. Exosomes were extracted from vitreous samples 10 PDR expression 372 determined using a quantitative polymerase chain reaction (qPCR) panel. We have demonstrated significant dysregulation 26 miRNAs. most remarkable findings...

Lupus retinopathy is the second most common eye involvement in systemic lupus erythematosus (SLE), associated with significant visual deterioration and well-known negative prognostic factor for survival. Ocular manifestation SLE, relating retina, ranges from asymptomatic vascular to vision devastating occlusions. Subclinical microvascular changes are undetectable slit lamp examination, hence underdiagnosed. Optical coherence tomography angiography (OCTA) a novel, easy interpret non-invasive...

purpose. Triamcinolone acetonide (TA) has been proposed as an adjuvant to pars plana vitrectomy with silicone oil for the surgical treatment of proliferative vitreoretinopathy and diabetic retinopathy. However, date no data about distribution pharmacokinetics lipophilic TA injected into have reported. methods. An artificial vitreous space chamber was filled oil. either or dispersed release using a continuous flow model measured spectrophotometrically. To determine antiproliferative cytotoxic...

Purpose: Primarily to determine the prevalence of various types glaucoma and ocular hypertension in Wroclaw inhabitants aged 40–79 years. The second aim study was number undiagnosed cases this population. Methods: A representative group population (4853 people from 40 79 years) recruited by a proportional simple random sampling selection with stratification. All participants underwent first, screening-stage examination, which included medical history interview, intraocular pressure (IOP)...

Background: Endotamponade of the vitreous body with silicone oil is a common procedure, being basis many vitreoretinal surgeries. However, emulsification may happen, which clinically relevant adverse event use. Methods: This review provides thorough analysis process. It focuses on describing factors affecting this as well its possible subsequent complications. Results: The viscosity oil, duration emulsification, status lens and other have an influence onset intensity emulsification....

To evaluate the release kinetics, biocompatibility and antiproliferative potential of a concentrated hydrophilic steroid formulation from commercially available sodium hyaluronate gels as adjunct in glaucoma surgery.Dexamethasone 1% (Healon) 2.3% (Healon 5) were mixed to yield formulations containing dexamethasone concentrations 4-20 mg/ml (7.7-38 mm). Non-cumulative cumulative into balanced salt solution (BSS) or phosphate buffered saline (PBS) was measured spectrophotometrically over 2-6...

Uveal melanoma is the most common primary intraocular malignancy in adults. The development of distant metastases associated with a poor prognosis. Ephrine receptors (Eph) are largest subpopulation tyrosine kinase receptors. They play an important role processes related to formation and progression cancer. aim study was evaluate expression ephrin EphA1, EphA5, EphA7 uveal its associations clinicopathological parameters, overall survival, disease-free survival. included 94 previously...

Background: Uveal melanoma is the most common primary intraocular malignancy in adults. In advanced cases, prognosis very poor. Thus far, no effective methods of pharmacotherapy this cancer have been found. The aim study was to evaluate expression PARP-1, best-known member family poly(ADP-ribose) polymerases, uveal and its associations with clinicopathological parameters, overall survival, disease-free survival. Methods: included 91 patients who underwent enucleation due melanoma. PARP-1...

Diabetic macular edema (DME) is responsible for three-quarters of vision-loss cases in diabetic eye disease. In most cases, early treatment by laser photocoagulation can only stabilize vision. Glucocorticoids have been used as a local pharmacological DME when the inflammation seems to pathological background.The aim study was establish effectiveness and safety intravitreal triamcinolone injections DME.Twenty mg triamcinole acetonide (IVTA) were applied 110 patients after ineffective...