A5045811374- Neurotransmitter Receptor Influence on Behavior
- Forensic Toxicology and Drug Analysis
- Psychedelics and Drug Studies
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Alcohol Consumption and Health Effects
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Chemical synthesis and alkaloids
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Pharmacogenetics and Drug Metabolism
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Receptor Mechanisms and Effects
- GABA and Rice Research
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Neuroendocrine regulation and behavior
- Maternal Mental Health During Pregnancy and Postpartum
- Stress Responses and Cortisol
- Metabolomics and Mass Spectrometry Studies
- Prenatal Substance Exposure Effects
- Poisoning and overdose treatments
- Veterinary Pharmacology and Anesthesia
- Olfactory and Sensory Function Studies
University of Arkansas for Medical Sciences
2016-2025
University of Pennsylvania
2020
Children's Hospital of Philadelphia
2020
University of Arkansas at Fayetteville
2019
National Institute on Alcohol Abuse and Alcoholism
2016
National Institute on Drug Abuse
2016
Virginia Commonwealth University
2014
University of Michigan
1999-2011
Emory University
2005-2010
Emory National Primate Research Center
2007-2010
Background K2 products are synthetic cannabinoid-laced, marijuana-like drugs of abuse, use which is often associated with clinical symptoms atypical marijuana use, including hypertension, agitation, hallucinations, psychosis, seizures and panic attacks. JWH-018, a prevalent cannabinoid, structurally distinct from Δ9-THC, the main psychoactive ingredient in marijuana. Since even subtle structural differences can lead to differential metabolism, formation novel, biologically active metabolites...
"K2/SPICE" products are commonly laced with aminoalkylindole synthetic cannabinoids (i.e., JWH-018 and JWH-073) touted as "legal" marijuana substitutes. Here we validate a liquid chromatography– tandem mass spectrometry (LC–MS/MS) method for measuring urinary concentrations of JWH-018, JWH-073, several potential metabolites each. The analytical procedure has high capacity sample throughput does not require solid phase or extraction. Evaluation human urine specimens collected after the...
Drug-elicited head-twitch behavior is a useful model for studying hallucinogen activity at 5-HT<sub>2A</sub> receptors in the mouse. Chemically diverse compounds active this assay yield biphasic dose-effect curves, but there no compelling explanation “descending” portion of these functions. A set experiments was designed to test hypothesis that induction mediated by agonist actions receptors, whereas inhibition observed higher doses results from competing 5-HT<sub>2C</sub> receptors. The...
3,4-Methylenedioxypyrovalerone (MDPV) is a common constituent of illicit "bath salts" products. MDPV chiral molecule, but the contribution each enantiomer to in vivo effects mice has not been determined. To address this, were trained discriminate 10 mg/kg cocaine from saline, and substitutions with racemic MDPV, <i>S</i>(+)-MDPV, <i>R</i>(−)-MDPV performed. Other implanted telemetry probes monitor core temperature locomotor responses elicited by under warm (28°C) or cool (20°C) ambient...
Abstract Acetaminophen (APAP) is the most-used over-the-counter analgesic among pregnant women. However, concerns have arisen over safety of APAP exposure during gestation. In particular, it’s been speculated that hepatotoxic metabolite APAP, N-acetyl-p-benzoquinone imine (NAPQI), forms in brain after maternal use therapeutic doses and leads to neurodevelopmental disorders (NDDs). metabolism understudied. Here, we tested hypothesis NAPQI can be generated by overdosing BTBR T+Itpr3tf/J...