A5101582740- Drug Transport and Resistance Mechanisms
- Adenosine and Purinergic Signaling
- Antioxidant Activity and Oxidative Stress
- Pharmacological Effects and Toxicity Studies
- Cholesterol and Lipid Metabolism
- Biochemical effects in animals
- Peroxisome Proliferator-Activated Receptors
- Free Radicals and Antioxidants
Tohoku Medical Megabank Organization
2018
Tohoku University
2018
Kanazawa Medical University
1996
The ATP-binding cassette (ABC) transporter A subfamily 8 (ABCA8) belongs to the ABCA6-like transporters subgroup, which is distinct from ABCA1-like subgroup in ABCA family. expression and function of short-size human ABCA8 lacking one two domains for ATP hydrolysis, are regularly present other transporters, have been reported. However, functional differences between full-size ABCA8, has domains, remain unknown. purpose study was clarify tissue profiles characteristics mouse human....
The purpose of the present study was to clarify molecular basis zonated drug distributions in mouse liver based on protein expression levels transporters and metabolizing enzymes periportal (PP) pericentral (PC) vein regions hepatic lobules. sulforhodamine 101 (SR-101), a substrate organic anion transporting polypeptides (Oatps), ribavirin, equilibrative nucleoside transporter 1 (Ent1), were elucidated frozen sections mice, which each compound had been intravenously administered. Regions...
Concentration of alpha-tocopherol (alpha-Toc.) in the rat lens (1, 4 and 12 months old) was determined single lenticular layers using gas chromatography mass spectrometry. The highest concentration alpha-Toc. found nucleus, followed by deeper anterior posterior cortices, shallow equatorial region. topographic distribution did not differ between lenses 1-, 4- 12-month-old rats. A significant decrease seen rats compared to those 1 month old. were almost same. changes relation age.