A5080195437- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Lipoproteins and Cardiovascular Health
- Obesity, Physical Activity, Diet
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive biology and impacts on aquatic species
- Microbial Metabolites in Food Biotechnology
- Nutrition, Genetics, and Disease
- Antioxidant Activity and Oxidative Stress
- Nutrition and Health in Aging
- Tea Polyphenols and Effects
- Lipid metabolism and biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Blood Pressure and Hypertension Studies
- Muscle metabolism and nutrition
University of Reading
2016-2025
New York University
2025
Instituto de Nutricion e Higiene de los Alimentos
2023
Unité de Nutrition Humaine
2013-2023
Wilfrid Laurier University
2022
Louisiana State University Health Sciences Center Shreveport
2020
Food & Nutrition
2012-2018
University of Indianapolis
2017
New York University Press
2009-2017
Indiana University – Purdue University Indianapolis
2005-2017
The present study was carried out to examine the effect of daily intake 10 g inulin on fasting blood lipid, glucose and insulin levels in healthy middle-aged men women with moderately raised total plasma cholesterol (TC) triacylglycerol (TAG) levels. This a double-blind randomized placebo-controlled parallel which fifty-four subjects received either or placebo for period 8 weeks. Fasting samples were collected before supplementation (baseline 1 2, separated by week) at weeks 4 8, follow-up...
Epidemiological studies have shown an inverse relationship between risk of CVD and intake whole grain (WG)-rich food. Regular consumption breakfast cereals can provide not only increase in dietary WG but also improvements to cardiovascular health. Various mechanisms been proposed, including prebiotic modulation the colonic microbiota. In present study, activity a maize-derived cereal (WGM) was evaluated double-blind, placebo-controlled human feeding study ( n 32). For period 21 d, healthy...
Background: In blood and tissues, dietary endogenously generated fatty acids (FAs) occur in free form or as part of complex lipid molecules that collectively represent the lipidome respective tissue. We assessed associations plasma lipids derived from high-resolution lipidomics with incident cardiometabolic diseases subsequently tested if identified risk-associated were sensitive to fat modification. Methods: The EPIC Potsdam cohort study (European Prospective Investigation into Cancer...
Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use lipidomics data from a randomized controlled intervention trial to construct multilipid score (MLS), summarizing the effects of replacing with on 45 lipid metabolite concentrations. In EPIC-Potsdam cohort, difference in MLS, reflecting better quality, was associated significant reduction incidence cardiovascular (-32%; 95% confidence interval...
The effect of fish oils and their active omega-3 fatty acid constituents, docosahexaenoic (DHA) eicosapentaenoic (EPA), were investigated on breast cancer growth. In in vivo experiments, mice fed diets that rich either (fish oil) or omega-6 (corn acids. Three weeks after implantation MDA-MB-231 cells, the tumor volume weight significantly lower (p < 0.05) for compared to those diets. Dietary oil also caused a 40% increase neutral sphingomyelinase (N-SMYase) activity tumors. tissues from...
Modifying dairy fat composition by increasing the MUFA content is a potential strategy to reduce dietary SFA intake for cardiovascular disease (CVD) prevention in population. To determine effects of consuming SFA-reduced, MUFA-enriched (modified) products, compared with conventional products (control), on fasting cholesterol profile (primary outcome), endothelial function assessed flow-mediated dilatation (FMD; key secondary and other cardiometabolic risk markers. A double-blind, randomized,...
The effects of replacing dietary saturated fatty acids (SFAs) with monounsaturated (MUFAs) and/or polyunsaturated (PUFAs) on the plasma lipidome in relation to cardiometabolic disease (CMD) risk is poorly understood. We aimed assess impact substituting SFAs unsaturated (UFAs) and examine relationship between lipid metabolites modulated by diet CMD risk. Plasma acid (FA) concentrations among 16 classes (within-class FAs) were measured a subgroup from Dietary Intervention VAScular function...
Chronic fish oil intervention had been shown to have a positive impact on endothelial function. Although high-fat meals often associated with loss of postprandial vascular reactivity, studies examining the effects fatty acids function in phase are limited. The aim present study was examine addition standard test meal reactivity. A total 25 men received random order either placebo (40 g mixed fat; acid profile representative U.K. diet) or (31 fat and 9 oil) two occasions. Vascular reactivity...
Although convincing lipid-lowering effects of the fructo-oligosaccharide, inulin, have been demonstrated in animals, attempts to reproduce similar man produced conflicting findings. This may be because much lower doses which can used due adverse gastrointestinal symptoms exhibited by most subjects consuming excess 15 g/d. There are nine studies reported literature investigated response blood lipids (usually total and LDL-cholesterol triacylglycerol) inulin or oligofructose supplementation...
Epidemiological evidence shows that a diet high in monounsaturated fatty acids (MUFA) but low saturated (SFA) is associated with reduced risk of CHD. The hypocholesterolaemic effect MUFA known there has been little research on the test meal and SFA composition postprandial lipid metabolism. present study investigated meals containing different proportions triacylglycerol non-esterified acid (NEFA) Thirty healthy male volunteers consumed three equal amounts fat (40g), (12, 17 24% energy)...