A5006026987- Plasmonic and Surface Plasmon Research
- Pancreatic function and diabetes
- Gold and Silver Nanoparticles Synthesis and Applications
- Optical Polarization and Ellipsometry
- Diabetes and associated disorders
- Orbital Angular Momentum in Optics
- Genetics and Neurodevelopmental Disorders
- Digestive system and related health
- Photonic and Optical Devices
- Neuroscience and Neuropharmacology Research
- Fibroblast Growth Factor Research
- Metamaterials and Metasurfaces Applications
- RNA Interference and Gene Delivery
- Optical Coatings and Gratings
- Kruppel-like factors research
- Esophageal and GI Pathology
- Thermal Radiation and Cooling Technologies
- Cancer-related gene regulation
- Regulation of Appetite and Obesity
- Neurotransmitter Receptor Influence on Behavior
- Photonic Crystals and Applications
- Cancer-related Molecular Pathways
- Magneto-Optical Properties and Applications
- Luminescence and Fluorescent Materials
- Antimicrobial Peptides and Activities
Indian Institute of Science Education and Research Kolkata
2015-2023
Purdue University West Lafayette
2022-2023
Princess Margaret Cancer Centre
2021
University of Toronto
2021
University of Massachusetts Chan Medical School
2007-2020
Tufts Medical Center
2000-2007
Tufts University
2000-2007
University Physicians
2003
The Ohio State University
1995-1998
Withybush General Hospital
1995
Spinning thermal radiation is a unique phenomenon observed in condensed astronomical objects, including the Wolf-Rayet star EZ-CMa and red degenerate G99-47, due to existence of strong magnetic fields. Here, by designing symmetry-broken metasurfaces, we demonstrate that spinning with nonvanishing optical helicity can be realized even without applying field. We design engineering dispersionless band emits omnidirectional radiation, where our reaches 39% fundamental limit. Our results firmly...
Gene expression programs required for differentiation depend on both DNA-bound transcription factors and surrounding histone modifications.Expression of the basic helix-loop-helix (bHLH) protein NeuroD1 is restricted to endocrine cells in gastrointestinal (GI) tract, where it important differentiation.RREB1 (RAS-responsive element binding 1), identified as a component CtBP corepressor complex, binds nearby DNA elements associate with NeuroD potentiate target gene.Transcriptional activation...
Androgen receptor (AR) plays an important role in normal prostate function as well the etiology of cancer. Activation AR is dictated by hormone binding and interactions with coregulators. Several these coregulators are known targets Ras-related signals. Recent evidence suggests that Ras activation may play a causal progression cancer toward more malignant hormone-insensitive phenotype. In present study, we used transcription factor-transcription factor interaction array method to identify...
<h3>Importance</h3> Many health care systems lack the efficiency, preparedness, or resources needed to address increasing number of patients with type 2 diabetes, especially in low- and middle-income countries. <h3>Objective</h3> To examine effects a quality improvement intervention comprising information communications technology contact nonphysician personnel on cardiometabolic risk factors diabetes 8 Asia-Pacific <h3>Design, Setting, Participants</h3> This 12-month multinational...
The gastrointestinal hormone peptide YY is a potent inhibitor of food intake and expressed early during differentiation intestinal pancreatic endocrine cells.In order to better understand the role in energy homeostasis development, we created mice with targeted deletion gene.All cells developed normally absence exception polypeptide (PP) cells, indicating that expression was not required for terminal differentiation.We used recombination-based cell lineage trace determine if were progenitors...
We study the near field to far evolution of spin angular momentum (SAM) density and Poynting vector scattered waves from spherical scatterers. The results show that at field, SAM are dominated by their transverse components. While former (transverse SAM) is independent helicity incident circular polarization state, latter vector) depends upon state. It further demonstrated interference electric magnetic scattering modes enhances both magnitudes spatial extent
Abstract Information on the polarization properties of scattered light from plasmonic systems are paramount importance due to fundamental interest and potential applications. However, such studies severely compromised experimental difficulties in recording full response nanostructures. Here, we report a novel Mueller matrix spectroscopic system capable acquiring complete information single isolated nanoparticle/nanostructure. The outstanding issues pertaining reliable measurements 4 ×...
Transcription factor Neurod1 is required for enteroendocrine progenitor differentiation and maturation. Several earlier studies indicated that ectopic expression of converted non- neuronal cells into neurons. However, the functional consequence has not been examined in GI tract, it known whether can similarly switch cell fates intestine. We generated a mouse line would enable us to conditionally express intestinal epithelial at different stages differentiation. Forced throughout epithelium...
<title>Abstract</title> Background: Type 2 diabetes (T2D) is the leading cause of chronic kidney disease (CKD) worldwide. Identifying clinical and laboratory associations with CKD in T2D can assist physicians targeting modifiable risk factors. In light limited data from India, CITE (CKD Indian Evaluation) study was conducted. Methods: The multicenter, cross-sectional included 3,325 patients 28 centres across India over three months. defined as a persistent decline function (eGFR < 60...
The basic helix-loop-helix protein BETA2/NeuroD activates transcription of the secretin gene and is essential for terminal differentiation secretin-producing enteroendocrine cells. However, in heterodimeric complexes with its partner proteins, BETA2 does not appear to be a strong activator by itself. Mutational analysis proximal enhancer identified several cis-acting elements addition E-box binding site BETA2. We expression cloning zinc finger RREB-1, also known exist as longer form, Finb,...
Fano resonance is observed in a wide range of micro- and nano-optical systems has been subject intensive investigations due to its numerous potential applications. Methods that can control or modulate by tuning some experimentally accessible parameters are highly desirable for realistic Here we present simple yet elegant approach using the Mueller matrix formalism controlling interference effect engineering resulting asymmetric spectral line shape an anisotropic optical system. The founded...
We previously demonstrated that acis-element (−489 to −467) in the brain-specific fibroblast growth factor (FGF)-1 promoter (FGF-1.B) binds multiple nuclear factors, and this binding enhances transcriptional activity of promoter. Here we report isolation three cDNA clones, VL1, VL2 VL3, from a human brain stem expression library using four tandem repeats 26-base pair sequence (−492 as probe. These clones represent variant bHLH protein E2–2/SEF2–1 having 12 additional nucleotides encoding...
The basic helix-loop-helix transcription factor NeuroD1 is required for late events in neuronal differentiation, maturation of pancreatic beta cells, and terminal differentiation enteroendocrine cells expressing the hormone secretin. NeuroD1-null mice demonstrated that this protein essential expression secretin gene murine intestine, yet it a relatively weak transcriptional activator by itself. present study shows Sp1 synergistically activate gene. NeuroD1, but not its widely expressed...
Background & AimsTransient expression of Neurog3 commits intestinal secretory progenitors to become enteroendocrine-biased and hence drive enteroendocrine differentiation. Loss in mouse resulted the depletion cells (EECs) an increase goblet cells. Earlier studies developing pancreas identified a role gene dosage endocrine exocrine cell fate allocation. We aimed determine whether controls choice progenitors.MethodsWe acquired mutant reporter mice carrying 2, 1, or null alleles study effect by...
The fate of perylene bisimide (PBI) H-aggregates as energy-harvesting materials depends on the ability to circumvent an extremely deleterious but efficient self-trapping process that scavenges long-lived excitons form deep excimeric traps. We present first ever report ambient-stable, bright, steady-state photoluminescence (PL) from exciton H-aggregated PBI crystal. crystal structure reveals a rotationally displaced arrangement chromophores, in which transition lowest energy state is...
Expression of alternatively spliced human FGF-1 (or aFGF) transcripts is regulated in a tissue-specific manner via multiple promoters. To identify the cis-regulatory elements brain-specific FGF-1.B promoter, we constructed series promoter deletions fused to luciferase reporter gene and transfected into an positive glioblastoma cell line, U1240MG, 1.B negative U1242MG. Results transient transfections indicate three that are involved regulation expression. The core located 40-base pair region...
Weak measurement enables faithful amplification and high-precision of small physical parameters is under intensive investigation as an effective tool in metrology for addressing foundational questions quantum mechanics. Here we demonstrate weak-value using the asymmetric spectral response Fano resonance pointer arising naturally precisely designed metamaterials, namely, waveguided plasmonic crystals. The weak coupling between polarization degree freedom arises due to a tiny shift two...
We report an unusual spin-direction-spin coupling phenomenon of light using the leaky quasiguided modes a waveguided plasmonic crystal. This is demonstrated as simultaneous input spin-dependent directional guiding waves (spin-direction coupling) and wave-vector-dependent spin acquisition (direction-spin scattered light. These effects, manifested forward inverse Hall effect in far field, other accompanying spin-orbit interaction effects are observed analyzed momentum (k) domain polarization...
Several reports have indicated that the product of retinoblastoma gene (Rb) complexes with transcription factor E2F. We present evidence DNA-binding Rb-E2F complex involves another cellular factor. Addition Rb to purified preparations E2F does not generate an can bind DNA, and in fact, we see inhibition ability On other hand, addition cruder results formation (E2Fr) DNA produces a distinct gel retardation assays. identified 60-kDa protein allows show this exerts its effect by directly interacting Rb.