A5102801903- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Aquaculture disease management and microbiota
- Neurobiology and Insect Physiology Research
- Immune Cell Function and Interaction
- Insect Utilization and Effects
- Studies on Chitinases and Chitosanases
- Antimicrobial Peptides and Activities
- Research on Leishmaniasis Studies
- TGF-β signaling in diseases
- Galectins and Cancer Biology
- Exercise and Physiological Responses
- Signaling Pathways in Disease
- RNA and protein synthesis mechanisms
- Thyroid Disorders and Treatments
University of Sussex
2013-2016
University of Aberdeen
2011-2012
Keele University
2008
University of Missouri
2001
Translation of hundreds small ORFs (smORFs) less than 100 amino acids has recently been revealed in vertebrates and Drosophila. Some these peptides have essential conserved cellular functions. In Drosophila, we predicted a particular smORF class encoding ~80 aa hydrophobic peptides, which may function membranes cell organelles. Here, characterise hemotin, gene an 88aa transmembrane peptide localised to early endosomes Drosophila macrophages. hemotin regulates endosomal maturation during...
Drosophila hemocytes compose the cellular arm of fly's innate immune system. Plasmatocytes, putative homologues to mammalian macrophages, represent ∼95% migratory hemocyte population in circulation and are responsible for phagocytosis bacteria apoptotic tissues that arise during metamorphosis. It is not known as how become activated from a sessile state response such infectious developmental cues, although hormone ecdysone has been suggested signal shifts behaviour quiescent at Here, we...
Background The larval stage of the model organism Drosophila is frequently used to study host-pathogen interactions. During embryogenesis cellular arm immune response, consisting macrophage-like cells known as plasmatocytes, extremely motile and functions phagocytise pathogens apoptotic bodies, well produce extracellular matrix. branch (post-embryonic) innate system consists three cell types—plasmatocytes, crystal lamellocytes—which are involved in phagocytosis, encapsulation melanisation...
Mouse thyroglobulin (MuTg)-sensitized spleen cells activated in vitro with MuTg induce experimental autoimmune thyroiditis (EAT) recipient mice a thyroid infiltrate consisting primarily of lymphocytes. A more severe and histologically distinct granulomatous form EAT (G-EAT) is induced when donor are together anti-interferon-γ (IFN-γ), anti-interleukin-2 receptor (IL-2R) monoclonal antibody (mAb), IL-12. Transforming growth factor-β (TGF-β) multifunctional cytokine that can both suppress...
Journal Article Aluminium: a natural adjuvant in Leishmania transmission via sand flies? Get access Rhayza Maingon, Maingon aCentre for Applied Entomology and Parasitology – Research Institute Science Technology Medicine, Keele University, Staffordshire, UK Search other works by this author on: Oxford Academic PubMed Google Scholar Amandeep Khela, Khela Christopher Sampson, Sampson Richard Ward, Ward Karen Walker, Walker bSchool of Life Sciences, Exley ⁎ cBirchall Centre Inorganic Chemistry...