A5016875663- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and characterization of novel inorganic/organometallic compounds
- Organoboron and organosilicon chemistry
- Organometallic Complex Synthesis and Catalysis
- Organophosphorus compounds synthesis
- Coordination Chemistry and Organometallics
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanomaterials for catalytic reactions
- Crystallography and molecular interactions
- Nanocluster Synthesis and Applications
- Synthetic Organic Chemistry Methods
- Synthesis and Properties of Aromatic Compounds
- Inorganic and Organometallic Chemistry
- Organic Chemistry Cycloaddition Reactions
- Organic Electronics and Photovoltaics
- Luminescence and Fluorescent Materials
- Catalytic Cross-Coupling Reactions
- Lipid metabolism and biosynthesis
- Organic and Molecular Conductors Research
Linköping University
2017
Uppsala University
2008-2016
A series of C,C-diacetylenic phosphaalkenes 1b-e has been prepared from 1-chloropenta-1,2-dien-4-ynes 6b-e in a reaction with Mes*PCl(2) (Mes* = 2,4,6-((t)Bu)(3)Ph) the presence LDA. Under identical conditions, isomeric butadiyne-substituted 2c-f can be obtained 3-chloropenta-1,4-diynes 5c-f. The title compounds represent rare examples diethynylethenes which constituting methylene replaced by phosphorus center. formation both isomers rationalized common pathway that involves allenyllithium...
Abstract Phosphole‐substituted phosphaalkenes (PPAs) of the general formula Mes*PC(CH 3 )(C 4 H 2 P(Ph))R 5 a – c (Mes*=2,4,6‐ t Bu Ph; R=2‐pyridyl ( ), 2‐thienyl b phenyl )) have been prepared from octa‐1,7‐diyne‐substituted by utilizing Fagan–Nugent route. The presence two differently hybridized phosphorus centers (σ ,λ and σ ) in offers possibility to selectively tune HOMO–LUMO gap compounds different reactivity heteroatoms. Oxidation sulfur proceeds exclusively at ‐phosphorus atom,...
Abstract The first direct alkynylation of C , ‐dibromophosphaalkenes by a reaction with sulfonylacetylenes is reported. Alkynylation proceeds selectively in the trans position relative to P substituent afford bromoethynylphosphaalkenes. Owing absence transition metals procedure, previously observed conversion dibromophosphaalkenes into phosphaalkynes through phosphorus analog Fritsch–Buttenberg–Wiechell rearrangement thus suppressed. bromoethynylphosphaalkenes can subsequently be converted...
An alternative synthesis of C-monoacetylenic phosphaalkenes trans-Mes*P=C(Me)(C≡CR) (Mes* = 2, 4, 6-tBu3Ph, R Ph, SiMe3) from C-bromophosphaalkenes cis-Mes*P=C(Me)Br using standard Sonogashira coupling conditions is described. Crystallographic studies confirm cis-trans isomerization the P=C double bond during Pd-catalyzed cross coupling, leading exclusively to trans-acetylenic phosphaalkenes. all synthesized compounds reveal extend π-conjugation over acetylene and π-systems.
Molecular tools for fluorescent imaging of specific compartments in cells are essential understanding the function and activity cells. Here, we report synthesis a series pyridyl- thienyl-substituted phospholes evaluation these dyes The proved to be successful staining cultured normal malignant due their properties low toxicity. Co-staining experiments demonstrated that probes target lipid droplets, which are, lipid-storage organelles found cytosol nearly all cell types. Our findings confirm...
Eine Verkleinerung der HOMO-LUMO-Bandlücke um 0.5 eV wird beobachtet, wenn die beiden terminalen Kohlenstoffatome eines Tetrain-verknüpften Bisalkens durch zwei Phosphorzentren ersetzt werden. Die acetylenischen Phosphaalkene sind aus einem ambivalenten Carben-artigen C5-Intermediat zugänglich und eignen sich für den Aufbau komplexer phosphor- kohlenstoffreicher Moleküle (siehe Bild; C grau, P violett).
The reactivity of bis-TMS-substituted C,C-diacetylenic phosphaalkene (A2PA) 1 in Sonogashira–Hagihara cross-coupling reactions has been examined. selective and successive deprotection the two silyl groups is enabled by steric bulk Mes* group which renders acetylenetrans to more reactive thereby facilitates consecutive couplings with iodoarenes. In situ transformation TMS-protected acetylenes into Cu(I)acetylides key step synthetic sequence enables preparation first dimeric A2PA linked a...
Abstract Acetylenic phosphaalkenes (APAs) are used as a novel type of ligands for the stabilization gold nanoparticles (AuNP). As demonstrated by variety experimental and analytical methods, both structural features APA, that is, PC well CC units essential NP stabilization. The presence intact APAs on AuNP is surface‐enhanced Raman spectroscopy (SERS), first principle calculations indicate bonding occurs most likely at defect sites Au surface. AuNP‐bound in chemical equilibrium with free...
Attempts to utilize C-ethylenic phosphaalkenes in metathesis reactions are discussed. Unprecedented reactivity is observed where the vinylphosphaalkene undergoes first step of catalytic cycle and cross-metathesis with phenylmethylene moiety Grubbs 2nd generation catalyst. However, homo-metathesis reaction form 1,6-diphosphahexa-1,3,5-triene not observed, presumably due steric constraints.
Abstract Acetylenic phosphaalkenes (APAs) are used as a novel type of ligands for the stabilization gold nanoparticles (AuNP). As demonstrated by variety experimental and analytical methods, both structural features APA, that is, PC well CC units essential NP stabilization. The presence intact APAs on AuNP is surface‐enhanced Raman spectroscopy (SERS), first principle calculations indicate bonding occurs most likely at defect sites Au surface. AuNP‐bound in chemical equilibrium with free...
Abstract Bis(trimethylsilyl)-terminated C,C-diacetylenic phosphaalkene was prepared from Mes*PCl2 and a propargylic Grignard reagent that in turn formed 3-bromo-1,5-bis(trimethylsilyl)penta-1,4-diyne Rieke-Mg.