A5067336484- Isotope Analysis in Ecology
- Analytical chemistry methods development
- Nuclear Physics and Applications
- Radioactive contamination and transfer
- Radioactive element chemistry and processing
- Mass Spectrometry Techniques and Applications
- Scientific Measurement and Uncertainty Evaluation
- Pesticide Residue Analysis and Safety
- Groundwater and Isotope Geochemistry
- Chemical Thermodynamics and Molecular Structure
- Heavy metals in environment
- Extraction and Separation Processes
- Archaeology and ancient environmental studies
- Geology and Paleoclimatology Research
- Radioactive Decay and Measurement Techniques
- Plant Micronutrient Interactions and Effects
- Geochemistry and Elemental Analysis
- Geochemistry and Geologic Mapping
- Electron and X-Ray Spectroscopy Techniques
- Mercury impact and mitigation studies
- Nuclear and radioactivity studies
- Trace Elements in Health
- Radioactivity and Radon Measurements
- Metabolomics and Mass Spectrometry Studies
- Astronomical and nuclear sciences
Federal Institute For Materials Research and Testing
2016-2025
National Institute of Standards and Technology
2020-2021
University of Bonn
2020
European Commission
2000-2009
Joint Research Centre
2007
Johannes Gutenberg University Mainz
1997-2002
Joint Research Center
2000-2001
Abstract Since the early 1950s, number of international measurement standards for anchoring stable isotope delta scales has mushroomed from 3 to more than 30, expanding 25 chemical elements. With development new instrumentation, along with and improved procedures studying naturally occurring isotopic abundance variations in natural technical samples, internationally distributed, secondary reference materials a specified value blossomed last six decades 150 materials. More half these were...
Abstract Following the reviews of atomic-weight determinations and other cognate data in 2015, 2017, 2019 2021, IUPAC (International Union Pure Applied Chemistry) Commission on Isotopic Abundances Atomic Weights (CIAAW) reports changes standard atomic weights. The symbol A r °(E) was selected for weight an element to distinguish it from E a specific substance P, designated (E, P). CIAAW has changed values weights five elements based recent terrestrial isotopic abundances: Ar (argon): 39.948...
K. G. Heumann, S. M. Gallus, Rädlinger and J. Vogl, Anal. At. Spectrom., 1998, 13, 1001 DOI: 10.1039/A801965G
Four methods of pulse counting detector dead time calculation were evaluated on two quadrupole ICP-MS instruments, using the criteria ease application and accuracy (i.e., reliable measurement uncertainty). Three based measurements 204Pb/208Pb isotope ratio in NIST Standard Reference Material NBS-982, while fourth method was comparison signals versus corresponding analog across a range signal intensities. The uncertainty result derived from each found to vary considerably, with some...
We report an analytical methodology for the quantification of sulfur in biological molecules via a species-unspecific postcolumn isotope dilution (online ID) approach using capillary electrophoresis (CE) coupled online with inductively plasma–mass spectrometry ID CE/ICP–MS). The method was optimized mixture standard compounds including sulfate, methionine, cysteine, cystine, and albumin, yielding compound recoveries between 98 105%. quantity is further converted to owing prior knowledge...
For the determination of elemental species, which normally exist at low concentrations in environment, coupling liquid chromatographic systems with inductively coupled plasma mass spectrometry (ICP-MS) is a powerful method respect to detection limit. However, accurate results are still problem trace analyses but can be obtained by application isotope dilution (IDMS). The developed LC–ICP-IDMS system consists high-performance chromatography pump, sample injection valve, separation column...
This article reviews the application of isotope dilution mass spectrometry (IDMS) to field reference material (RM) characterisation within past 15 years, focusing on elemental and species analysis. Emphasis is placed liquid solid RMs IDMS measurements highest analytical quality. Basic principles, as well equation system, are being revisited. Different calibration strategies, such single, double or triple IDMS, critically reviewed achievable uncertainties discussed. Differences in thermal...
Isotopic reference materials are essential to enable reliable and comparable isotope data. In the case of boron only a very limited number such is available, thus preventing adequate quality control measurement results validation analytical procedures. To address this situation unique set two (ERM‐AE102a ‐AE104a) three offset δ 11 B (ERM‐AE120, ‐AE121 ‐AE122) were produced certified. The present article describes production certification procedure in detail. isotopic composition all was...
We present a comprehensive chemical and mass spectrometric method to determine boron isotopic compositions of plant tissue. The including dry ashing, three-step ion chromatographic boron-matrix separation, (11)B/(10)B isotope ratio determinations using the Cs(2)BO(2)(+) graphite technique has been validated certified reference quality control materials. developed is capable δ(11)B values in tissue down concentrations 1 mg/kg with an expanded uncertainty ≤1.7‰ (k = 2). determined reveal...
Alzheimer's disease (AD) is characterized by accumulation of tau and amyloid-beta in the brain, recent evidence suggests a correlation between associated protein aggregates trace elements, such as copper, iron, zinc. In AD, distorted brain redox homeostasis complexation hyperphosphorylated may alter isotopic composition essential mineral elements. Therefore, high-precision analysis reveal changes these We used inductively coupled plasma-mass spectrometry (ICP-MS)-based techniques to...
Isotope reference materials are essential to enable reliable and comparable isotope data. This article reviews the work in this field within past years. The focus is on all stable elements, except for classical isotopes (H, C, N, O, S) radioactive elements. Currently available listed. limitations of synthetic mixtures being used characterize these discussed, as well materials, such uncertainty homogeneity. needs present research variations considered compared current materials. disagreement...
Three different MC-ICPMS instruments were calibrated by means of synthetic isotope mixtures to enable absolute Mg ratios with expanded uncertainties ≤0.15‰.
Combination of microdroplet generator and ICP-ToF-MS for nanoparticle sizing via on-line ID (on-line ID-MDG-sp-ICP-ToF-MS). 194 Pt/ 195 Pt ratio was used the particles, while 182 W/ 183 W simultaneously mass bias correction.
Stable metal isotopes have received increasing attention as medical biomarkers due to their potential detect changes in metabolism related diseases. In particular, copper stable are a powerful tool identify isotopic variation between tumors and healthy tissue, suggesting application cancer diagnosis. However, mechanisms causing isotope fractionation, such redox- or bond-forming reactions interactions of metals during transmembrane import export, less well understood. Here, we established an...
ICP-MS has played a key role in inorganic chemical metrology for 25 years, from the 1993 CIPM feasibility study which led to establishment of CCQM. Since that time, Inorganic Analysis Working Group CCQM organised 56 international comparisons involving measurements by and, recent comparison, 16 different national institutes submitted their results using technique. Metrological applications currently address an enormous range wide variety instrumentation, calibration strategies and...
The European Green Deal’s ambition for zero pollution requires development of highly sensitive techniques to detect ultra-low amounts pollutants and determine their isotope ratios, where mass spectrometry is a key method. project bridges the traceability gap between activity measurements – particularly estimation bias establishes new tools pollutant tracing. SI-traceable reference materials measurement procedures are being developed that significantly reduce uncertainty detection limits,...
A sensitive and fast method for direct determinations of dissolved organic carbon (DOC) in bulk samples chromatographically separated fractions by inductively coupled plasma isotope dilution mass spectrometry (ICP−IDMS) is developed. 13C-enriched spike solution benzoic acid used the step. Equal ionization efficiencies are obtained carbon, independent type molecular weight substance, which most important precondition DOC ICP−IDMS. The detection limits achieved 0.3 mg L-1 analyses 7 × 10-4 μg...
Triple IDMS has been applied for the first time to quantification of element concentrations. It compared with single and double obtained on same sample set in order evaluate advantages disadvantages triple over as an analytical reference procedure. The measurement results single, are indistinguishable, considering rounding due individual uncertainties. As expected, relative expanded uncertainties (k = 2) achieved (0.08%) dramatically smaller than those (1.4%). yields smallest 2, 0.077%)...
Boron isotope studies on technical materials and geological environmental samples are one hot topic in nowadays research. Provenance of artefacts, food other products might become another one, as several recent demonstrate. Typically boron determinations have been carried out by TIMS. To open up this research field to a broader scientific community we developed two analytical procedures for based single collector SF-ICPMS combined with sample preparation procedure consisting dry-ashing three...