Samantha O. Brown

ORCID: 0000-0002-0112-3032
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About
Contact & Profiles
Research Areas
  • Decision-Making and Behavioral Economics
  • Cancer Risks and Factors
  • Neural and Behavioral Psychology Studies
  • Visual perception and processing mechanisms
  • Neurotransmitter Receptor Influence on Behavior
  • Pelvic and Acetabular Injuries
  • Anorectal Disease Treatments and Outcomes
  • Nutritional Studies and Diet
  • Pharmacological Effects and Assays
  • Cancer, Lipids, and Metabolism
  • Growth Hormone and Insulin-like Growth Factors
  • Employee Welfare and Language Studies
  • Stuttering Research and Treatment
  • Metabolism, Diabetes, and Cancer
  • Neuroendocrine regulation and behavior
  • Pelvic floor disorders treatments
  • Apelin-related biomedical research

Icahn School of Medicine at Mount Sinai
2020-2025

Allen Institute for Brain Science
2024-2025

National Institute on Drug Abuse
2021

Tisch Cancer Institute
2020

Cabarrus College of Health Sciences
2010

Northern General Hospital
2004

Those with diabetes mellitus are at high-risk of developing psychiatric disorders, especially mood yet the link between hyperglycemia and altered motivation has not been thoroughly explored. Here, we characterized value-based decision-making behavior a streptozocin-induced diabetic mouse model on Restaurant Row, naturalistic neuroeconomic foraging paradigm capable behaviorally capturing multiple decision systems known to depend dissociable neural circuits. Mice made self-paced choices daily...

10.1038/s42003-025-07500-6 article EN cc-by-nc-nd Communications Biology 2025-01-21

Those with diabetes mellitus are at high-risk of developing psychiatric disorders, yet the link between hyperglycemia and alterations in motivated behavior has not been explored detail. We characterized value-based decision-making a streptozocin-induced diabetic mouse model on naturalistic neuroeconomic foraging paradigm called Restaurant Row. Mice made self-paced choices while limited time-budget accepting or rejecting reward offers as function cost (delays cued by tone-pitch) subjective...

10.1101/2024.01.04.574210 preprint EN PubMed Central 2024-01-10

Abstract Traditional approaches for evaluating if compounds are reinforcing, and thus a risk abuse, include preclinical self-administration procedures conducted in the absence of alternative reinforcers. While track record this approach determining abuse potential is good, that predicting efficacy addiction treatments not. An alternate would be economic choice between drug nondrug rewards, with parametrically varied options from trial to trial. This promote goal-directed decisions reward...

10.1038/s41386-021-00996-6 article EN cc-by Neuropsychopharmacology 2021-04-08

Those with diabetes mellitus are at high-risk of developing psychiatric disorders, yet the link between hyperglycemia and alterations in motivated behavior has not been explored detail. We characterized value-based decision-making a streptozocin-induced diabetic mouse model on naturalistic neuroeconomic foraging paradigm called Restaurant Row. Mice made self-paced choices while limited time-budget accepting or rejecting reward offers as function cost (delays cued by tone-pitch) subjective...

10.1101/2024.01.04.574210 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-01-04

Aims: Milligan Morgan haemorrhoidectomy is the traditional operation for haemorrhoids with significant external component. Circular staples are alternative method of treatment in this group patients. Here we audit complications after stapled patients and without permanent haemorrhoidal prolapse.

10.1055/s-2004-834535 article EN Endoscopy 2004-09-23
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