Speech intelligibility declines with age and sensorineural hearing damage (SNHL). However, it remains unclear whether cochlear synaptopathy (CS), a recently discovered form of SNHL, significantly contributes to this issue. CS refers damaged auditory-nerve synapses that innervate the inner hair cells there is currently no go-to diagnostic test available. Furthermore, age-related can comprise various aspects (e.g., cell damage, CS) each play role in impaired sound perception. To explore link...

Recent studies suggest that millions of people may be at risk permanent impairment from cochlear synaptopathy, the age-related and noise-induced degeneration neural connections in inner ear. This study examines electrophysiological responses to stimuli designed improve detection damage subjects with normal hearing sensitivity. The resultant correlations word recognition performance are consistent a contribution deficits noise abilities.

The perceptual consequences of cochlear synaptopathyare presently not well understood as adirect quantification synaptopathyi sn ot possible in humans.To study its role for human hearing, recent studies have instead correlated changes basic suprathreshold psychoacoustic tasks with individual differences subcortical EEG responses, aproxy measure synaptopathy.It is clear whether the reported missing relationships between quantities and are due to adopted methods, or am inor synaptopathy sound...

Over the past decades, different types of auditory models have been developed to study functioning normal and impaired processing. Several can simulate frequency-dependent sensorineural hearing loss (SNHL) in this way be used develop personalized audio-signal processing for aids. However, determine individualized SNHL profiles, we rely on indirect noninvasive markers cochlear auditory-nerve (AN) damage. Our progressive knowledge functional aspects subtypes stresses importance incorporating...

Even though the principles of recording brain electrical activity remain unchanged since their discovery, acquisition has seen major improvements. The cEEGrid, a recently developed flex-printed multi-channel sensory array, can be placed around ear and successfully record well-known cortical electrophysiological potentials such as late auditory evoked (AEPs) or P300. Due to its fast easy application well long-lasting signal window, cEEGrid technology offers great potential flexible 'wearable'...

Abstract Speech intelligibility declines with age and sensorineural hearing damage (SNHL). However, it remains unclear whether cochlear synaptopathy (CS), a recently discovered form of SNHL, significantly contributes to this issue. CS refers damaged auditory-nerve synapses that innervate the inner hair cells there is currently no go-to diagnostic test available. Furthermore, age-related can comprise various aspects (e.g., cell damage, CS) each play role in impaired sound perception. To...

Abstract The envelope following response (EFR) has been proposed as a non-invasive marker of synaptopathy in animal models. However, its amplitude is affected by the spread basilar-membrane excitation and other coexisting sensorineural hearing deficits. This study aims to (i) improve frequency specificity EFR introducing derived-band (DBEFR) technique (ii) investigate effect lifetime noise exposure, age outer-hair-cell (OHC) damage on DBEFR magnitudes. Additionally, we adopt modelling...

Abstract The aim of this work was to investigate the perceptual relevance frequency following response syllable /da/ for speech intelligibility in noise based on age and hearing deficits. Recordings auditory evoked potential from young normal (NH) older individuals with both high-frequency (HF) loss were analyzed. EFR metrics obtained quiet condition calculated correlated reception. envelope responses analyzed terms amplitude, latency robustness. first simulated form predictions effect...

Abstract The perceptual consequences of cochlear synaptopathy are presently not well understood as a direct quantification is possible in humans. To study its role for human hearing, recent studies have instead correlated changes basic supra-threshold psychoacoustic tasks with individual differences subcortical EEG responses, proxy measure synaptopathy. It clear whether the reported missing relationships between quantities and due to adopted methods, or minor sound perception. We address...

Abstract Auditory de-afferentation, a permanent reduction in the number of innerhair-cells and auditory-nerve synapses due to cochlear damage or synaptopathy, can reliably be quantified using temporal bone histology immunostaining. However, there is an urgent need for non-invasive markers synaptopathy study its perceptual consequences live humans develop effective therapeutic interventions. While animal studies have identified candidate auditory-evoked-potential (AEP) their interpretation...

Abstract Emerging evidence suggests that cochlear synaptopathy is a common feature of sensorineural hearing loss, but it not known whether electrophysiological metrics targeting in animals can be applied to broad range people, such as those with impaired audiograms. This study investigates the applicability subcortical measures associated auditory brainstem responses (ABRs) and envelope following (EFRs) older participants high-frequency sloping important for development reliable sensitive...

The origins and perceptual consequences of supra-threshold hearing deficits are not well understood. Sensory neural likely contributors, underlining the need for an objective measure which quantifies contributors complements audiometric measures sensory loss. envelope-following response (EFR) is sensitive to fiber loss in animal models has been proposed as a marker. However, its diagnostic sensitivity humans relationship speech intelligibility still unclear. Here we argue that between...

Abstract Over the past decades, different types of auditory models have been developed to study functioning normal and impaired processing. Several can simulate frequency-dependent sensorineural hearing loss (SNHL), in this way be used develop personalized audio-signal processing for aids. However, determine individualized SNHL profiles, we rely on indirect non-invasive markers cochlear auditory-nerve (AN) damage. Our progressive knowledge functional aspects subtypes stresses importance...