A5071672445- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Cellular transport and secretion
- Retinal and Optic Conditions
- Cardiac Health and Mental Health
- Cannabis and Cannabinoid Research
- Agricultural pest management studies
- Metabolomics and Mass Spectrometry Studies
- Research on scale insects
- Pharmacogenetics and Drug Metabolism
- Lipid metabolism and biosynthesis
- Kruppel-like factors research
- Neuroscience and Neural Engineering
- Bioinformatics and Genomic Networks
- Insect Resistance and Genetics
- Peroxisome Proliferator-Activated Receptors
- Retinal Diseases and Treatments
- Genetic Neurodegenerative Diseases
- Pain Management and Placebo Effect
- Pain Management and Treatment
Nanjing University of Chinese Medicine
2022-2023
National Evidenc- based healthcare Collaborating Agency
2023
St. Vincent's Hospital
2023
Catholic University of Korea
2023
Nanjing Drum Tower Hospital
2023
Duke Medical Center
2020-2022
Jiangsu Province Hospital
2022
Duke University Hospital
2020
Nantong University
2017
University of Kentucky
2014-2015
Protein aggregates can form in the cytoplasm of cell and are accumulated at aggresomes localized to microtubule organizing center (MTOC) where they subsequently degraded by autophagy. In this process, engulfed into autophagosomes which fuse with lysosomes for protein degradation. A member class II histone deacetylase family, 6(HDAC6) has been shown be involved both aggresome formation fusion making it an attractive target regulate aggregation. The scaffolding sequestosome 1(SQSTM1)/p62 also...
Mutations in PARKIN (PARK2), an ubiquitin ligase, cause early onset Parkinson disease. Parkin was shown to bind, ubiquitinate, and target depolarized mitochondria for destruction by autophagy. This process, mitophagy, is considered crucial maintaining mitochondrial integrity suppressing Parkinsonism. Here, we report that under moderate stress, parkin does not translocate induce mitophagy; rather, it stimulates connectivity. Mitochondrial stress-induced fusion requires PINK1 (PARK6),...
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) forms a major component of the postsynaptic density where its functions in synaptic plasticity are well established, but presynaptic actions poorly defined. Here we show that CaMKII binds directly to C-terminal domain Ca(V)2.1 channels. Binding is enhanced by autophosphorylation, and kinase-channel signaling complex persists after dephosphorylation removal Ca(2+)/CaM stimulus. Autophosphorylated can bind channel synapsin-1...
The Class II histone deacetylase, HDAC6, has been shown to be involved in cell motility, aggresome formation and mitochondria transport. HDAC6 deacetylase activity regulates α-tubulin acetylation levels thus plays a critical role these processes. In turn, can regulated by interaction with various proteins including multiple kinases. Kinase mediated phosphorylation of lead either increased or reduced activity. Our previous research that sequestosome1/p62 (SQSTM1/p62) interacts its As...
The dynein motor protein complex is required for retrograde transport of vesicular cargo and aggregated proteins along microtubules processing degradation at perinuclear aggresomes. Disruption this process leads to dysfunctional endosome accumulation increased aggregation in the cell cytoplasm, both pathological features neurodegenerative diseases. However, exact mechanism functionality these pathways still being elucidated. Here, we show that scaffolding SQSTM1 directly interacts with...
Chronic kidney disease (CKD) is considered a global public health problem with high morbidity and mortality. Yishen Qingli Heluo granule (YQHG) representative traditional Chinese medicine (TCM) remedy for clinical treatment of CKD. This study aims to explore the mechanism YQHG on CKD through network pharmacology experimental validation.Traditional Medicine Systems Pharmacology (TCMSP) database wide-scale literature mining were applied screen active compounds YQHG. Multiple bioinformatic...
Objective Endothelial function may improve with enhanced external counterpulsation (EECP) or acupuncture. This study aimed to evaluate the feasibility of acupoint stimulation combined EECP (acupoint-EECP) for endothelial cell in patients essential hypertension.Methods Thirty hypertensive were, randomly divided into two groups, 15 acupoint-EECP group, and control which 3 cases were lost by week 6. Both groups treated continued medicine. The participants group received therapy, 45 min each...
Abstract Mitochondrial failure caused by Parkin mutations contributes to Parkinson’s disease. binds, ubiquitinates, and targets impaired mitochondria for autophagic destruction. Robust mitophagy involves peri-nuclear concentration of Parkin-tagged mitochondria, followed dissemination juxtanuclear mitochondrial aggregates, efficient sequestration individualized autophagosomes. Here, we report that the execution complex mitophagic events requires active lipid remodeling. recruits phospholipase...
Abstract Background: We determined the cost-effectiveness of anti-vascular endothelial growth factor (VEGF) intravitreal injection versus panretinal photocoagulation (PRP) for patients with proliferative diabetic retinopathy (PDR) in South Korea. Methods: simulated four treatment strategies using PRP and anti-VEGF by constructing a Markov model hypothetical cohort 50-year-old PDR patients: (1) only; (2) (3) first; (4) first. Results: In this analysis, compared only-PRP, incremental ratiowas...