A5083879152- Sports Performance and Training
- Muscle activation and electromyography studies
- Robotic Locomotion and Control
- Sports injuries and prevention
- Balance, Gait, and Falls Prevention
- Winter Sports Injuries and Performance
- Cardiovascular and exercise physiology
- Lower Extremity Biomechanics and Pathologies
- Spaceflight effects on biology
- Sports Dynamics and Biomechanics
- Prosthetics and Rehabilitation Robotics
- Ubiquitin and proteasome pathways
- Genetics and Physical Performance
- Cerebral Palsy and Movement Disorders
- Motor Control and Adaptation
- Physical Activity and Health
- Muscle metabolism and nutrition
- Biomimetic flight and propulsion mechanisms
- Veterinary Equine Medical Research
- Diabetic Foot Ulcer Assessment and Management
- Bat Biology and Ecology Studies
- Muscle Physiology and Disorders
- Cellular transport and secretion
- Aerospace Engineering and Energy Systems
- Mechanics and Biomechanics Studies
University of Milan
2016-2025
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
2021-2025
Istituto di Fisiologia Clinica
1982-2024
Fred Hutch Cancer Center
2024
University of Siena
2021-2024
University of Genoa
2021-2022
Accademia Nazionale dei Lincei
2018-2020
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2012
Manchester Metropolitan University
2000-2007
Institute of Molecular Bioimaging and Physiology
2003-2006
The costs of walking (Cw) and running (Cr) were measured on 10 runners a treadmill inclined between −0.45 to +0.45 at different speeds. minimum Cw was 1.64 ± 0.50 J · kg −1 m 1.0 0.3 m/s speed the level. It increased positive slopes, attained 17.33 1.11 +0.45, reduced 0.81 0.37 −0.10. At steeper it reach 3.46 0.95 −0.45. Cr 3.40 0.24 level, independent speed. 18.93 1.74 1.73 0.36 −0.20. 3.92 mechanical efficiencies above +0.15 below −0.15 those concentric eccentric muscular contraction,...
To investigate mechanical work, efficiency, and antagonist muscle co-activation with a view to better understand the cause of elevated metabolic cost walking (C(W)) in older adults.Metabolic, electromyographic measurements were made as healthy young (YOU; n = 12, age 27 +/- 3 years) (OLD; 20, 74 men equivalent body mass leg length walked on treadmill at four speeds (ranging from 0.83 1.67 m s(-1)).Net (above resting) C(W), determined by indirect calorimetry was 31% higher (average across...
ABSTRACT Three-dimensional motion capture and metabolic assessment were performed on four standardbred horses while walking, trotting galloping a motorized treadmill at different speeds. The mechanical work was partitioned into the internal (WINT), due to speed changes of body segments with respect centre mass, external (WEXT), position mass environment. estimated total (WTOT=WINT+WEXT) increased speed, (C) remained rather constant. As consequence, ‘apparent efficiency’ (effAPP=WTOT/C) from...
ABSTRACT The metabolic cost and the mechanical work of running at different speeds gradients were measured on five human subjects. was partitioned into internal (Wint) due to speed changes body segments with respect centre mass external (Wext) position in environment. Wext further divided a positive part negative , associated energy increases decreases, respectively, over stride period. For all constant speeds, most economical gradient -10.6±0.5% (S.D., N=5) 146.8±3.8 ml O2 kg−1 km−1. At...
The purpose of this study was to investigate whether the voluntary neural drive and excitability reflex arc could be modulated by training, even in old age. To aim, effects a 16-wk strengthening program on plantar flexor activation (VA) maximum Hoffman (H(max))-to-maximum M wave (M(max)) ratio were investigated 14 elderly men (65-80 yr). After isometric contraction (MVC) increased 18% (P < 0.05) weight-lifting ability 24% 0.001). Twitch time decreased 8% 0.01), but no changes half relaxation...
Five subjects walked and ran at overlapping speeds different gradients on a motorized treadmill. At each gradient the speed was obtained which walking running have same metabolic cost (Sm) of spontaneous (Ss) transition between two gaits measured. Ss found to be statistically lower than Sm all gradients, difference being in range 0.5-0.9 km h-1. The motion analysis reveals that increasing speed: (1) percentage recovery, an index mechanical energy saving related pendulum-like characteristic...
Triple-negative breast cancer (TNBC) is a very aggressive and heterogeneous group of tumors. In order to develop effective therapeutic strategies, it therefore essential identify the subtype-specific molecular mechanisms underlying disease progression resistance chemotherapy. TNBC cells are highly dependent on exogenous cystine, provided by overexpression cystine/glutamate antiporter SLC7A11/xCT, fuel glutathione synthesis promote an oxidative stress response consistent with their high...
1. The metabolic cost and the mechanical work at different speeds during uphill, level downhill walking have been measured in four subjects. 2. has partitioned into internal (W(int)), due to speed changes of body segment with respect centre mass (BCM), external (W(ext)), related position BCM environment. 3. W(ext) further divided a positive part W+ext) negative one (W‐(ext)), associated energy increases decreases, respectively, over stride period. 4. For all constant most economical gradient...
The effects of bed rest on the cardiovascular and muscular parameters which affect maximal O 2 consumption ( V O2,max ) were studied. fractional limitation imposed by these after was analysed. , standard procedure, cardiac output (Q̇ max ), pulse contour method, measured during graded cyclo‐ergometric exercise seven subjects before a 42‐day head‐down tilt rest. Blood haemoglobin concentration ([Hb]) arterialized blood gas analysis determined at highest work load. Muscle fibre types,...
The energetics and mechanics of walking were investigated at different speeds, both the freely chosen stride frequency (FCSF) imposed ones (up to +/- 40% FCSF). Metabolic energy expenditure was minimized FCSF for each speed. Motion analysis allowed calculate: mechanical internal work rate (Wint), needed move segments with respect body center mass (bcm); external (Wext), necessary bcm in environment; total (Wtot), equal Wint+Wext. Wtot explains metabolic optimization only high while Wext,...
SUMMARY The aim of the present study was to quantify improvements in economy and efficiency surface swimming brought about by use fins over a range speeds (v) that could be sustained aerobically. At comparable speeds, energy cost (C) when with 40 %lower than without them; compared at same metabolic power, decrease C allowed an increase v 0.2 ms-1. Fins only slightly amplitude kick (by 10 %) but cause large reduction (about frequency. frequency leads parallel internal work rate (Ẇint, 75 %at...
Skipping, a gait children display when they are about four- to five-years-old, is revealed be more than behavioural peculiarity. By means of metabolic and biomechanical measurements at several speeds, the relevance skipping shown extend from links between bipedal quadrupedal locomotion (namely galloping) understanding why it could choice in low-gravity conditions, some aspects evolution (ground reaction forces seem originate pushing walking unnaturally high speeds). When time-courses...
The dynamics of body center mass (BCoM) 3D trajectory during locomotion is crucial to the mechanical understanding different gaits. Forward Dynamics (FD) obtains BCoM motion from ground reaction forces while Inverse (ID) estimates position and speed capture segments. These two techniques are widely used by literature on estimation BCoM. Despite specific pros cons both methods, FD less biased considered as golden standard, ID strongly depend segmental model adopted schematically represent...
Hypogravity challenges bipedal locomotion in its common forms. However, as previously theoretically and empirically suggested, humans can rely on "skipping," a less gait available functional analog (perhaps vestigium) of quadrupedal gallop, to confidently move when gravity is much lower than Earth. We set up 17-m-tall cavaedium (skylight shaft) with bungee rubber body-suspension system treadmill investigate the metabolic cost biomechanics low-gravity (Mars, Moon) locomotion. Although...
A novel apparatus, composed by a controllable treadmill, computer, and an ultrasonic range finder, is here proposed to help investigation of many aspects spontaneous locomotion. The acceleration or deceleration the subject, detected sensor processed used accelerate decelerate treadmill in real time. system has been assess, eight subjects, self-selected speed walking running, maximum "reasonable" walking, minimum reasonable running at different gradients (from level up +25%). This evidenced...