A5030203118- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Viral gastroenteritis research and epidemiology
- Enterobacteriaceae and Cronobacter Research
- T-cell and B-cell Immunology
- Clinical Laboratory Practices and Quality Control
- Antimicrobial Resistance in Staphylococcus
- Bacillus and Francisella bacterial research
- Virology and Viral Diseases
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Urinary Tract Infections Management
- Vector-borne infectious diseases
- Animal Disease Management and Epidemiology
- vaccines and immunoinformatics approaches
- Myasthenia Gravis and Thymoma
- Pleural and Pulmonary Diseases
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Musculoskeletal synovial abnormalities and treatments
LabCorp (United States)
2024
bioMérieux (United States)
2023
Medical Group of the Carolinas
2021
Louisiana State University Health Sciences Center Shreveport
2014-2020
Atrium Medical Cente
2019
Carolinas Healthcare System
2016-2017
Louisiana State University in Shreveport
2013
Wake Forest University
2008
Brigham and Women's Hospital
1991
The comparative efficacy of ceftazidime-avibactam and meropenem-vaborbactam for treatment carbapenem-resistant Enterobacteriaceae (CRE) infections remains unknown. This was a multicenter, retrospective cohort study adults with CRE who received or ≥72 hours from February 2015 to October 2018. Patients localized urinary tract infection repeat drug exposures after the first episode were excluded. primary endpoint clinical success compared between groups. Secondary endpoints included 30- 90-day...
We have compared the responses of purified neonatal and adult B lymphocytes to stimulation by anti-Ig antibodies, which are functional analogues Ag, Th cells. Neonatal cells markedly deficient in proliferative antibodies + IL-4 or conjugated dextran, both induce strong proliferation absence T lymphocytes. Anti-Ig actually inhibit cells, even polyclonal stimuli such as LPS. However, Ig secretion presence Ag that bind cell subsequently presented Thus, lymphocytes, cross-linking membrane has a...
Abstract Background Group B Streptococcus (GBS) remains a significant cause of neonatal infection, but the maternal risk factors for GBS colonization remain poorly defined. We hypothesized that there may be an association between antibiotic exposure during pregnancy and and/or presence inducible clindamycin resistance (iCLI-R) in isolates from GBS-colonized pregnant women. Methods A retrospective cohort study was performed at Louisiana State University Health Sciences Center – Shreveport...
Bacteremia is associated with significant morbidity and mortality. Timely, appropriate therapy may improve clinical outcomes, therefore, determining which patients benefit from more comprehensive diagnostic strategies (i.e., direct specimen testing) could be of value. We performed an assessment procalcitonin (PCT) characteristics in the discrimination bacteremic hospitalizations. analyzed 71,105 encounters 14,846 visits bacteremia alongside 56,259 without admission. The area under...
Abstract Clinical microbiology laboratories are responsible for confirming the aetiology of infectious diseases and providing antimicrobial susceptibility testing results. Traditional culture-based can be augmented by more rapid modalities to provide clinically actionable information as quickly possible. Despite improvements in patient outcomes, many clinical facing challenges in-sourcing these technologies. Depending on a multitude factors, including size, location population served,...
Abstract Background Historically, clinical mycobacteriology laboratories used the nucleic acid hybridization-based AccuProbe assay manufactured by Hologic, Inc., to rapidly rule in or out Mycobacterium tuberculosis (MTB) and members of M. avium-intracellulare complex (MAC). The value this test was its ability in/out MTB from positive broth cultures allow initiation appropriate antimicrobial therapy infection prevention practices. Recent discontinuation commercial left a gap testing available...
Abstract Background Options for treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections were historically limited to antibiotics with efficacy and significant toxicities. Ceftazidime/avibactam (CA) meropenem/vaborbactam (MV) are superior older regimens; however, a direct comparison the agents is lacking. This study compared clinical outcomes including recurrence infection emergence drug resistance in patients who received CA vs. MV CRE infections. Methods was multicenter,...
Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to 15q PML gene sequence. The resulting fusion product plays role in development and maintenance of APL, very rarely found other acute myeloid (AML) subtypes. Rare complex APL genomic rearrangements have deletions. Here we report deletion case AML without differentiation. To our knowledge, this first example subtype.
Enterococci are important causes of hospital-acquired infections worldwide.Enterococci inherently resistant to cephalosporins and aminoglycosides, can acquire new resistance mechanisms during therapy.Vancomycin occurs through acquisition the vanA or vanB operons.Discrepancies in vancomycin determination among different antimicrobial susceptibility testing systems have been reported.Erroneous identification could lead inappropriate therapy for patients harboring a vancomycin-resistant...
Molecular testing has been shown to improve turnaround time (TAT) for identifying bloodborne pathogens. Early results can inform directed escalation or de-escalation of antimicrobial therapy. Paired with antibiotic stewardship, rapid pathogen identification reduce utilization and patient outcomes. However, many these studies were in single site institutions. We evaluated implementation the BioFireÒ FilmArray Blood Culture Identification System (BCID) across 3 acute care facilities utilizing...