A5010840830- Renal Diseases and Glomerulopathies
- Parasites and Host Interactions
- Vasculitis and related conditions
- Retinal Development and Disorders
- Systemic Lupus Erythematosus Research
- Dialysis and Renal Disease Management
- Retinal Diseases and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Research on Leishmaniasis Studies
- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- Complement system in diseases
- Asthma and respiratory diseases
- Liver physiology and pathology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Sepsis Diagnosis and Treatment
- Renal and Vascular Pathologies
- Inflammasome and immune disorders
- RNA Interference and Gene Delivery
- HER2/EGFR in Cancer Research
- Erythropoietin and Anemia Treatment
- Vector-borne infectious diseases
- Phytochemistry and biological activity of medicinal plants
- Macrophage Migration Inhibitory Factor
- Hemoglobinopathies and Related Disorders
Nantong University
2014-2025
Affiliated Hospital of Nantong University
2014-2025
Shandong Provincial Hospital
2020-2024
Shandong First Medical University
2021-2024
First Affiliated Hospital of Zhengzhou University
2023
Shandong University
2022
Beijing Tsinghua Chang Gung Hospital
2022
Tsinghua University
2022
Fudan University
2021
Shanghai Stomatological Hospital
2009-2021
Tobacco-related diseases such as lung cancer cause over 4.2 million deaths annually, with approximately 400,000 per year occurring in the US. Genotoxic effects of tobacco components have been described, but on signaling pathways normal cells not described. Here, we show activation serine/threonine kinase Akt nonimmortalized human airway epithelial vitro by two cigarette smoke, nicotine and tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Activation or NNK...
Tobacco-related diseases such as lung cancer cause over 4.2 million deaths annually, with approximately 400,000 per year occurring in the US. Genotoxic effects of tobacco components have been described, but on signaling pathways normal cells not described. Here, we show activation serine/threonine kinase Akt nonimmortalized human airway epithelial vitro by two cigarette smoke, nicotine and tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Activation or NNK...
Abstract Introduction Among various lupus renal vascular changes, thrombotic microangiopathy (TMA) presented with the most severe clinical manifestations and high mortality. The pathogenesis of TMA in systemic erythematosus (SLE) was complicated. aim this study to assess manifestations, laboratory characteristics, pathological features risk factors for outcomes nephritis patients co-existing a large cohort China. Methods Clinical histopathological data 148 biopsy-proven were retrospectively...
To evaluate changes in epidermal growth factor receptor (EGFR) phosphorylation and its downstream signaling tumor surrogate tissue biopsies patients with metastatic breast cancer treated erlotinib, an EGFR tyrosine kinase inhibitor, to assess relationships between biomarkers normal tissues pharmacokinetics.Eighteen were orally 150 mg/d of erlotinib. Ki67, EGFR, phosphorylated (pEGFR), mitogen-activated protein (pMAPK), AKT (pAKT) 15 paired tumor, skin, buccal mucosa (at baseline after 1...
Nanotechnology approaches have tremendous potential for enhancing treatment efficacy with lower doses of chemotherapeutics. Nanoparticle (NP)-based drug delivery are poorly developed childhood leukemia. Dexamethasone (Dex) is one the most common chemotherapeutic drugs used in In this study, we encapsulated Dex polymeric NPs and validated their antileukemic vitro vivo. an average diameter 110 nm were assembled from amphiphilic block copolymer poly(ethylene glycol) (PEG) poly(ε-caprolactone)...
It is very challenging to visualize implantable medical devices made of biodegradable polymers in deep tissues. Herein, we designed a novel macromolecular contrast agent with ultrahigh radiopacity (iodinate content > 50%) via polymerizing an iodinated trimethylene carbonate monomer into the two ends poly(ethylene glycol) (PEG). A set thermosensitive and polyester-PEG-polyester triblock copolymers varied polyester compositions synthesized by us, which were soluble water at room temperature...
Although nephritogenic autoantibodies are considered to play a central role in the initiation of lupus nephritis, whether these associated with renal clinical and pathological activity or outcome is still controversial. Here, we investigated associations certain serum disease large cohort Chinese patients nephritis. One hundred thirty-six biopsy-proven nephritis long-term follow up data were studied. Sera at biopsy tested for panel autoantibodies, including anti-nuclear antibodies,...
Acute kidney injury (AKI) is a syndrome characterized by an accelerating decrease in renal function short time. Thymol one of the main components thyme species and has variety pharmacological effects. Here, we investigated whether thymol could ameliorate rhabdomyolysis (RM)-induced AKI its related mechanism. Glycerol was used to induce RM-associated rats. Rats received (20 mg/kg/day or 40 mg/kg/day) gavage 24 h before glycerol injection until 72 after daily. Kidney identified measuring serum...
Abstract The pattern recognition receptor (PRR) scavenger class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and innate immune responses to pathogen infections. However, little is known about role SR-A host adaptive infection. Here we show with mouse models helminth Schistosoma japonicum infection heat-inactivated Mycobacterium tuberculosis stimulation that regulated by pathogens suppresses IRF5 nuclear translocation direct interaction. Reduced abundance...
Following Schistosoma japonicum (S. japonicum) infection, granulomatous responses are induced by parasite eggs trapped in host organs, particular the liver, during acute stage of disease. While excessive liver can lead to more severe fibrosis and circulatory impairment chronically infected host. However, exact mechanism hepatic granuloma formation has remained obscure. In this study, we for first time showed that follicular helper T (Tfh) cells recruited upregulate injury S....
Alendronate (AL), a potent oral bisphosphonate, blocks the secretion of matrix metalloproteinase-2 and establishment bone metastases in animal models. Ketoconazole (KT) has demonstrated activity androgen independent prostate cancer (AIPC). In this study we determined whether KT plus AL produced acceptable disease responses compared with alone. As experimental design, 72 patients progressive AIPC metastatic to were randomized receive (1,200 mg daily) hydrocortisone (H) (30 or without (40...
Abstract Purpose: The purpose of this study was to determine the toxicities and characterize pharmacokinetics docetaxel flavopiridol in patients with metastatic breast cancer. Experimental Design: Docetaxel administered at an initial dose 60 mg/m2 followed 24 hours by a 72-hour infusion 50 mg/m2/d every 3 weeks. Because dose-limiting myelosuppression occurred, schedule amended docetaxel, mg/m2, escalating doses (starting dose, 26 mg/m2/d) as 1-hour daily for days. Pharmacokinetic studies...
Objective: The objectives of this study were to examine the clinical profile critically ill patients with septic acute kidney injury (AKI) and investigate characteristics associated outcome patients. Methods: Data from 582 collected retrospectively reviewed. Patients divided into two groups: without AKI development development. Baseline characteristics, laboratory, other data compared between these groups, correlations examined. further groups according survival outcome, variables...
Lunasin is a naturally occurring peptide isolated from soybeans and has been explored in cancer treatment. inhibits NF-κB activation thus pro-inflammatory cytokine mediator production macrophages. In this study we demonstrate that lunasin can effectively suppress allergic airway inflammation two murine models of asthma. an OVA+Alum sensitization model, intranasal treatment at the time OVA challenges significantly reduced total cells counts bronchoalveolar lavage (BAL) fluid eosinophilia,...
Emodin is a natural anthraquinone derivative that occurs in many Chinese medicinal herbs.
The pathophysiological significance of variable region glycosylation autoantibodies is still unclear. In the current study, influence N-linked oligosaccharides on reactivity three autoantibody specificities was investigated with Sambucus nigra agglutinin (SNA), which mainly binds to terminal α2, 6-linked sialic acid IgG.Twenty-seven patients serum positive anti-neutrophil cytoplasmic (ANCA) against myeploperoxidase (MPO) or proteinase 3 (PR3), glomerular basement membrane (GBM) were...