A5023307268- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
- Infant Nutrition and Health
- Nicotinic Acetylcholine Receptors Study
- Infant Development and Preterm Care
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Birth, Development, and Health
- Neonatal Health and Biochemistry
- Genetic Associations and Epidemiology
- Biomedical Research and Pathophysiology
- Pregnancy and preeclampsia studies
- Williams Syndrome Research
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Celiac Disease Research and Management
- Autoimmune Bullous Skin Diseases
- Neurological diseases and metabolism
- Genetics and Neurodevelopmental Disorders
- Ocular Oncology and Treatments
- Alcoholism and Thiamine Deficiency
- Genomics and Rare Diseases
- Congenital heart defects research
- Chronic Lymphocytic Leukemia Research
University of Pittsburgh
2018-2021
Children's Hospital of Pittsburgh
2017-2019
University of Colorado Denver
2009-2012
University of Denver
2010
University of South Alabama
1998-1999
National Institutes of Health
1998-1999
University of Kentucky
1998-1999
Charité - Universitätsmedizin Berlin
1999
Tulane University
1998
UBTF (upstream binding transcription factor) exists as two isoforms; UBTF1 regulates rRNA by RNA polymerase 1, whereas UBTF2 mRNA 2. Herein, we describe 4 patients with very similar patterns of neuroregression due to recurrent de novo mutations in (GRCh37/hg19, NC_000017.10: g.42290219C > T, NM_014233.3: c.628G A) resulting the same amino acid change both and (p.Glu210Lys [p.E210K]). Disease onset our cohort was at 2.5 3 years characterized slow progression global motor, cognitive behavioral...
The chromosomal region, 15q13-q14, including the α7 nicotinic acetylcholine receptor gene, CHRNA7, is a replicated region for schizophrenia. This study fine-mapped genes at 15q13-q14 to determine whether association unique CHRNA7.Family-based and case-control studies were performed on Caucasian-non-Hispanic African-American individuals from 120 families as well 468 individual patients with schizophrenia 144 well-characterized controls. Single-nucleotide polymorphism (SNP) markers genotyped,...
Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis pathway (CBP), and are used for prevention of cardiovascular disease. The anti-inflammatory effects statins may also provide therapeutic benefits have led to their use clinical trials preeclampsia, a pregnancy-associated inflammatory condition, despite current classification as category X (i.e. contraindicated during pregnancy). In developing neocortex, products CBP play essential roles proliferation...
Synthetic glucocorticoids (sGCs) such as dexamethasone (DEX), while used to mitigate inflammation and disease progression in premature infants with severe bronchopulmonary dysplasia (BPD), are also associated significant adverse neurologic effects reductions myelination abnormalities neuroanatomical development. Ciclesonide (CIC) is a sGC prodrug approved for asthma treatment that exhibits limited systemic side effects. Carboxylesterases enriched the lower airways convert CIC glucocorticoid...
Abstract Vaccination with peptide mimics of tumor antigens, or mimotopes, is a potential strategy for antigen-specific immunotherapy cancer. To determine how to elicit the most effective cytotoxic response against tumors, we have assembled set mimotopes AH1, immunodominant antigen from mouse CT26 tumor. Although AH1 an ineffective immunogen, vaccination some very successful in protecting mice growth. The majority AH1-specific T cells responding vaccine express V-beta 8 gene segments....
Abstract Synthetic glucocorticoid (sGC) administration in pregnancy has greatly reduced the risk of respiratory distress, intraventricular hemorrhage and necrotizing enterocolitis premature infants. Significant evidence accumulated human animal models that prenatal exposure to sGCs can lead adverse side effects such as birthweight, increased for hypertension, cardiovascular, metabolic, neurological problems later life. Phosphorylation receptor (GR) been shown play a significant role cells...
666 Administration of non-depleting anti-CD4 antibody can lead to long-term allograft survival and possibly transplantation tolerance in rodents, but mechanisms underlying vivo immunomodulation by CD4 ligands are incompletely understood. Using peptomer, a CD4-binding peptide multimer, we have previously identified attenuation IL-2-induced nuclear translocation STAT5 as downstream effect ligation (CD4L). To further characterize this interference CD4L with IL-2 receptor (IL-2R) signaling,...
1021 CD4 ligation (CD4L) with anti-CD4 antibodies (αCD4s), gp120 or IL-16 can down-modulate T lymphocyte activation and promote long-term immunological hyporesponsiveness, resulting in prolonged allograft survival organ transplantation under αCD4. cell depletion is not obligatory for these effects, they are as of yet poorly understood. We have previously shown that a gp120-derivative interfere interleukin-2 receptor (IL-2R) signaling by attenuating IL-2-induced JAK3-tyrosine phosphorylation...
Abstract Premature birth leads to a significant increase in adverse clinical outcomes, including Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Necrotizing Enterocolitis and Intraventricular Hemorrhage. Synthetic Glucocorticoids (sGC) are administered prenatally pregnant mothers at risk reduce the chance of these complications. However, there is correlation between long-term neurological defects infant use sGC prenatally. The sGCs have been linked development cerebral palsy...
666 Administration of non-depleting anti-CD4 antibody can lead to long-term allograft survival and possibly transplantation tolerance in rodents, but mechanisms underlying vivo immunomodulation by CD4 ligands are incompletely understood. Using peptomer, a CD4-binding peptide multimer, we have previously identified attenuation IL-2-induced nuclear translocation STAT5 as downstream effect ligation (CD4L). To further characterize this interference CD4L with IL-2 receptor (IL-2R) signaling,...