A5090808779- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Reproductive System and Pregnancy
- Bioinformatics and Genomic Networks
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Gene expression and cancer classification
- Circular RNAs in diseases
The University of Texas MD Anderson Cancer Center
2018-2024
The diversity and heterogeneity within high-grade serous ovarian cancer (HGSC), which is the most lethal gynecologic malignancy, not well understood. Here, we perform comprehensive multi-platform omics analyses, including integrated analysis, immune monitoring on primary metastatic sites from highly clinically annotated HGSC samples based a laparoscopic triage algorithm patients who underwent complete gross resection (R0) or received neoadjuvant chemotherapy (NACT) with excellent poor...
Abstract Adult-type granulosa cell tumors of the ovary (aGCTs) are rare gynecologic malignancies that exhibit a high frequency somatic FOXL2 c.C402G (p.Cys134Trp) mutation. Treatment relapsed aGCT remains significant clinical challenge. Here we show, using whole-exome and cancer gene panel sequencing 79 aGCTs from two independent cohorts, truncating mutation histone lysine methyltransferase KMT2D (also known as MLL2 ) is recurrent event in aGCT. Mono-allelic -truncating mutations more...
Abstract Background Low-grade serous ovarian cancer (LGSOC) is a rare disease that occurs more frequently in younger women than those with high-grade disease. The current treatment suboptimal and better understanding of the molecular pathogenesis this required. In study, we compared proteogenomic analyses LGSOCs from short- long-term survivors (defined as < 40 > 60 months, respectively). Our goal was to identify novel mutations, proteins, mRNA transcripts are dysregulated LGSOC,...
Abstract Adult-type granulosa cell tumors (aGCT) are rare ovarian sex cord with few effective treatments for recurrent disease. The objective of this study was to characterize the tumor microenvironment (TME) primary and aGCTs identify correlates disease recurrence. Total RNA sequencing (RNA-seq) performed on 24 pathologically confirmed, cryopreserved aGCT samples, including 8 16 tumors. After read alignment quality-control filtering, DESeq2 used differentially expressed genes (DEG) between...
<p>RNA Sequencing QC Metrics</p>
Abstract Background: A growing proportion of women diagnosed with atypical hyperplasia (AH) and early-stage endometrioid endometrial cancer (EEC) require nonsurgical treatment options. Our previously published phase II clinical trial the levonorgestrel intrauterine device (LIUD) for AH grade 1 EEC (G1EEC) demonstrated 83% response rate at year; however, prospective long-term follow-up data determinants duration to LIUD are limited. Methods: Follow-up from patients that participated in our as...
Abstract Background: Hematopoietic lineage differentiation is subjected to genetic mutations that, due fitness advantages, might give rise clonally expanded populations. Clonal hematopoiesis of indeterminate potential (CHIP) defined as the outgrowth a single clone driven by acquired somatic in hematopoietic stem cells (HSCs), absence hematological abnormalities. Previous studies have shown association CH with aging and higher risk developing secondary hematologic malignancies cancer patients...
Abstract Background: Adult-type granulosa cell tumors (AGCT) are rare ovarian sex cord that exhibit near-universal FOXL2 c.C402G (p.Cys134Trp) hotspot mutations. AGCT recurrence is difficult to predict and almost always incurable after relapse. Little known about the relationship between intra-tumor immune stromal composition Objective: To compare global gene expression profiles primary recurrent AGCTs, characterize tumor microenvironment (TME), identify correlates of disease recurrence....
<div>Abstract<p>Adult-type granulosa cell tumors (aGCT) are rare ovarian sex cord with few effective treatments for recurrent disease. The objective of this study was to characterize the tumor microenvironment (TME) primary and aGCTs identify correlates disease recurrence. Total RNA sequencing (RNA-seq) performed on 24 pathologically confirmed, cryopreserved aGCT samples, including 8 16 tumors. After read alignment quality-control filtering, DESeq2 used differentially expressed...
<p>Clinical Characteristics by Patient</p>
<p>Differentially Expressed Genes</p>
<p>S1. Heatmap of unsupervised hierarchical clustering the top 1000 most variable genes.S2. Violin plots showing expression levels genes previously identified as differentially expressed between primary and recurrent tumors in Haltia et al., 2020.S3. Gene set enrichment analysis performed with GO terms KEGG pathways that primarily immune-related hormone-regulated gene sets are altered aGCTs.S4. results enriched significantly comparison tumors.S5. Boxplot fraction each noncancerous cell...
<p>Clinical Characteristics by Patient</p>
<p>RNA Sequencing QC Metrics</p>
<p>Differentially Expressed Genes</p>
<div>Abstract<p>Adult-type granulosa cell tumors (aGCT) are rare ovarian sex cord with few effective treatments for recurrent disease. The objective of this study was to characterize the tumor microenvironment (TME) primary and aGCTs identify correlates disease recurrence. Total RNA sequencing (RNA-seq) performed on 24 pathologically confirmed, cryopreserved aGCT samples, including 8 16 tumors. After read alignment quality-control filtering, DESeq2 used differentially expressed...
<p>S1. Heatmap of unsupervised hierarchical clustering the top 1000 most variable genes.S2. Violin plots showing expression levels genes previously identified as differentially expressed between primary and recurrent tumors in Haltia et al., 2020.S3. Gene set enrichment analysis performed with GO terms KEGG pathways that primarily immune-related hormone-regulated gene sets are altered aGCTs.S4. results enriched significantly comparison tumors.S5. Boxplot fraction each noncancerous cell...
<p>RNA Sequencing QC Metrics</p>
<p>RNA Sequencing QC Metrics</p>
<p>Clinical Characteristics by Patient</p>
<p>S1. Heatmap of unsupervised hierarchical clustering the top 1000 most variable genes.S2. Violin plots showing expression levels genes previously identified as differentially expressed between primary and recurrent tumors in Haltia et al., 2020.S3. Gene set enrichment analysis performed with GO terms KEGG pathways that primarily immune-related hormone-regulated gene sets are altered aGCTs.S4. results enriched significantly comparison tumors.S5. Boxplot fraction each noncancerous cell...
<p>S1. Heatmap of unsupervised hierarchical clustering the top 1000 most variable genes.S2. Violin plots showing expression levels genes previously identified as differentially expressed between primary and recurrent tumors in Haltia et al., 2020.S3. Gene set enrichment analysis performed with GO terms KEGG pathways that primarily immune-related hormone-regulated gene sets are altered aGCTs.S4. results enriched significantly comparison tumors.S5. Boxplot fraction each noncancerous cell...
<p>Differentially Expressed Genes</p>
<p>Differentially Expressed Genes</p>