A5050335101- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Glioma Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Immunotherapy and Immune Responses
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Immunotherapy and Biomarkers
- Shoulder Injury and Treatment
- Management of metastatic bone disease
- Spinal Hematomas and Complications
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immune cells in cancer
- Nerve Injury and Rehabilitation
- Pain Management and Treatment
- Spinal Dysraphism and Malformations
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Radiation Dose and Imaging
- Pituitary Gland Disorders and Treatments
St. Joseph's Hospital and Medical Center
2018-2025
Barrow Neurological Institute
2018-2025
The Spine Institute
2023
Duke University Hospital
2016-2019
Duke Medical Center
2015-2019
Duke University
2015-2019
Piedmont International University
2019
Neurological Surgery
2016
Johns Hopkins Hospital
2010-2011
Johns Hopkins Medicine
2010
Purpose: T-cell dysfunction is a hallmark of glioblastoma (GBM). Although anergy and tolerance have been well characterized, exhaustion remains relatively unexplored. Exhaustion, characterized in part by the upregulation multiple immune checkpoints, known contributor to failures amid checkpoint blockade, strategy that has lacked success thus far GBM. This study among first examine, credential as bona fide, T cells infiltrating human murine GBM.Experimental Design: Tumor-infiltrating...
Pedicle screws are used to stabilize all 3 columns of the spine, but can be technically demanding place. Although intraoperative fluoroscopy and stereotactic-guided techniques slightly increase placement accuracy, they also associated with increased radiation exposure patient surgeon as well operative time.To describe critically evaluate our 7-year institutional experience pedicle in thoracic lumbar spine using a free-hand technique.We retrospectively reviewed records patients undergoing...
Pedicle screws provide efficient stabilization along all 3 columns of the spine, but they can be technically demanding to place, with malposition rates ranging from 5% 10%. Intraoperative electromyographic (EMG) monitoring has capacity objectively identify a screw breaching medial pedicle cortex that is in proximity nerve root. The purpose this study describe and evaluate authors' 7-year institutional experience intraoperative EMG during placement lumbar determine clinical utility...
Abstract Purpose: Chimeric antigen receptor (CAR) T cells have shown promise against solid tumors, but their efficacy has been limited, due in part, to immunosuppression by CD4+FoxP3+ regulatory (Tregs). Although lymphodepletion is commonly used deplete Tregs, these regimens are nonspecific, toxic, and provide only a narrow window before Tregs repopulate hosts. Importantly, CARs also inadvertently potentiate providing source of IL2 for Treg consumption. We explored whether disruption the...
Although pituitary adenoma is classified as benign, Cushing disease associated with significant morbidity due to the numerous sequelae of elevated cortisol levels. Successful therapy for remains elusive high rates treatment-refractory recurrence. The frequent emergence lymphocytic hypophysitis following checkpoint blockade other cancers, well expression PD-L1 on adenomas, suggest a role immunotherapy.This study confirms functioning adenomas and first evaluate efficacy (anti-PD-L1) in...
Single-position surgery in prone position is a novel technique for lateral interbody fusion with pedicle screw fixation. We performed radiographic comparison of patients treated spondylolisthesis using the (PL) transpsoas approach versus traditional dual (DP) (lateral decubitus then prone). Thirty consecutive were PL (n = 15) 15). Radiographic factors groups retrospectively compared. The similar age, sex, body mass index, and implant size, but there more 15° (vs. 10°) cages inserted group....
The authors evaluated the feasibility of using first clinical-grade confocal laser endomicroscopy (CLE) system fluorescein sodium for intraoperative in vivo imaging brain tumors.A CLE cleared by FDA was used 30 prospectively enrolled patients with 31 tumors (13 gliomas, 5 meningiomas, 6 other primary tumors, 3 metastases, and 4 reactive tissue). A neuropathologist classified images as interpretable or noninterpretable. Images were compared corresponding frozen permanent histology sections,...
Diastolic and systolic parameters of left ventricular performance were characterized from high-frequency time-activity curves obtained in 10 normal volunteers (mean age 29 +/- 4 yr), 25 patients with coronary arteries, 50 artery disease (CAD) at rest during three stages exercise radionuclide angiography. In the ejection fraction was 65 5% (SD) 78 (p less than .001). arteries 64 72 8% .0001). CAD resting 60 10% that 61 13% = NS). Peak diastolic filling rate first half diastole, peak rate,...
Neurosurgical guidelines recommend maintaining mean arterial pressure (MAP) between 85 and 90 mm Hg following acute spinal cord injury (SCI). In our hospital, SCI patients receive orders for MAP targeting 72 hours admission, but it is unclear how often the patient's meets target whether or not this affects outcome. We hypothesized that proportion of measurements ≥85 would be associated with neurologic recovery.Spinal blunt mechanism admitted 2014 2019 were identified from registry a level 1...
INTRODUCTION: Increasing pressures limit resident surgical autonomy. Innovative use of technology represents an opportunity to accelerate learning and revolutionize traditional training paradigms. Virtual reality (VR) is one such that may enhance neurosurgical training. METHODS: Twelve residents (six at two institutions, respectively) were given access the VR simulation for home eight weeks. Simulated pedicle screw accuracy was recorded by application mixed effects logistic linear regression...